bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 18, 2024
Abstract
Phosphorylation
of
hundreds
protein
extracellular
domains
is
mediated
by
two
kinase
families,
yet
the
significance
these
kinases
underexplored.
Here,
we
find
that
presynaptic
release
tyrosine
directed-ectokinase,
Vertebrate
Lonesome
Kinase
(VLK/Pkdcc),
necessary
and
sufficient
for
direct
interaction
between
EphB2
GluN1
at
synapses,
phosphorylation
ectodomain
EphB2,
injury-induced
pain.
Pkdcc
an
essential
gene
in
nervous
system,
VLK
found
synaptic
vesicles,
released
from
neurons
a
SNARE-dependent
fashion.
expressed
nociceptive
sensory
where
neuron-specific
knockout
renders
mice
impervious
to
post-surgical
pain,
without
changing
proprioception.
defines
mechanism
regulates
protein-protein
non-opioid-dependent
pain
response
injury.
One-Sentence
Summary
Synaptic
interactions
are
regulated
spinal
cord.
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
The
death
signaling
complex
comprising
extrasynaptic
NMDAR
and
TRPM4
plays
a
pivotal
role
in
the
pathogenesis
of
ischemic
stroke.
Targeting
protein-protein
interactions
between
represents
promising
therapeutic
strategy
for
Herein,
we
describe
discovery
novel
series
NMDAR/TRPM4
interaction
interface
inhibitors
aimed
at
enhancing
neuroprotective
efficacy
optimizing
pharmacokinetic
profiles.
representative
compound
Frontiers in Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Сен. 18, 2023
Alzheimer’s
disease
(AD)
emerges
as
a
perturbing
neurodegenerative
malady,
with
profound
comprehension
of
its
underlying
pathogenic
mechanisms
continuing
to
evade
our
intellectual
grasp.
Within
the
intricate
tapestry
human
health
and
affliction,
enteric
microbial
consortium,
ensconced
within
milieu
gastrointestinal
tract,
assumes
role
cardinal
significance.
Recent
epochs
have
borne
witness
investigations
that
posit
marked
divergences
in
composition
gut
microbiota
between
individuals
grappling
AD
those
favored
by
robust
health.
The
composite
vicissitudes
configuration
assembly
are
posited
choreograph
participatory
inception
progression
AD,
facilitated
conduit
acknowledged
gut-brain
axis.
Notwithstanding,
precise
nature
this
interlaced
relationship
remains
enshrouded
recesses
obscurity,
poised
for
an
exhaustive
revelation.
This
review
embarks
upon
endeavor
focalize
meticulously
mechanistic
sway
exerted
plunging
profoundly
into
execution
interventions
govern
microorganisms.
In
doing
so,
it
bestows
relevance
therapeutic
stratagems
form
bedrock
AD’s
management,
all
whilst
casting
prospective
gaze
horizon
medical
advancements.
Heterochronic
parabiosis
consists
of
surgically
connecting
the
circulatory
systems
a
young
and
an
old
animal.
This
technique
serves
as
model
to
study
circulating
factors
that
accelerate
aging
in
organisms
exposed
blood
or
induce
rejuvenation
blood.
Despite
promising
results,
exact
cellular
molecular
mechanisms
remain
unclear,
so
this
aims
explore
elucidate
them
more
detail.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 4, 2024
Abstract
The
development
of
scaffolds
for
repairing
critical-sized
bone
defects
heavily
relies
on
establishing
a
neuro-vascularized
network
proper
penetration
nerves
and
blood
vessels.
Despite
significant
advancements
in
using
artificial
bone-like
infused
with
various
agents,
challenges
remain.
Natural
tissue
consists
porous
matrix
surrounded
by
periosteum,
unique
piezoelectric
properties
essential
growth.
Drawing
inspiration
from
this
assembly,
we
developed
periosteum-bone-mimicking
bilayer
scaffold
regeneration
defects.
periosteum-like
layer
features
double
hydrogel
composed
chelated
alginate,
gelatin
methacrylate,
sintered
whitlockite
nanoparticles,
emulating
the
viscoelastic
natural
periosteum.
is
structure
chitosan
bioactive
hydroxyapatite
created
through
biomineralization
process.
Unlike
conventional
scaffolds,
bioinspired
significantly
enhances
osteogenesis,
angiogenesis,
neurogenesis
combined
low-intensity
pulsed
ultrasound-assisted
stimulation.
Such
scheme
in
vivo.
results
suggest
that
could
serve
as
an
effective
self-powered
electrical
stimulator
to
expedite
under
dynamic
physical
