The
ability
to
distinguish
strangers
from
familiar
individuals
is
crucial
for
the
survival
of
most
mammalian
species.
In
humans,
an
inability
recognize
kin
and
engage
in
appropriate
behaviors
associated
with
several
types
dementia,
including
Alzheimer’s
disease.
Mice
preferentially
spend
more
time
investigating
a
novel
individual
relative
individual.
Yet,
how
social
novelty
related
information
drives
increased
investigation
animal
remains
poorly
understood.
Recent
evidence
has
implicated
ventral
hippocampus
(vHPC)
as
key
node
encoding
about
conspecific
identity.
Of
particular
interest
are
vHPC
projections
lateral
septum
(LS),
region
that
been
driving
wide
range
motivated
behaviors.
this
study
using
chemogenetics,
optogenetics
monosynaptic
rabies
tracing,
we
identified
vHPC-LS-ventral
tegmental
area
(VTA)
pathway
necessary
mice
investigate
conspecifics.
Using
established
LS
neurons
make
direct
connections
onto
dopaminergic
VTA.
Thus,
have
potential
via
which
identity
could
be
transformed
drive
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Фев. 4, 2023
Abstract
Maternal
behaviors,
which
are
crucial
for
the
survival
of
mammalian
infants,
require
coordinated
operation
multiple
brain
regions
to
process
infant
cues,
make
decisions,
and
execute
motor
plans.
Although
these
processes
likely
demand
higher
cognitive
functions,
top-down
regulation
limbic
parental
programs
remains
poorly
understood.
Here,
we
show
that
orbitofrontal
cortex
(OFC)
excitatory
projection
neurons
promote
alloparental
caregiving
behaviors
in
female
mice.
By
chronic
microendoscopy,
observed
robust
yet
adaptable
representations
pup-directed
anticipatory
motor-related
activities
within
OFC
significantly
overlapped
with
those
related
nonsocial
reward
signals.
The
inactivation
output
reduced
phasic
midbrain
dopamine
(DA)
specifically
tied
pup
retrieval
impaired
modulation
DA
release
ventral
striatum
during
acquisition
behaviors.
Collectively,
our
study
identifies
signals
from
modulate
plasticity
system,
thereby
promoting
Teaser
Orbitofrontal
facilitate
virgin
mice
by
modulating
system.
Current Opinion in Neurobiology,
Год журнала:
2023,
Номер
83, С. 102811 - 102811
Опубликована: Ноя. 14, 2023
Midbrain
dopaminergic
neurons
are
a
relatively
small
group
of
in
the
mammalian
brain
controlling
wide
range
behaviors.
In
recent
years,
increasingly
sophisticated
tracing,
imaging,
transcriptomic,
and
machine
learning
approaches
have
provided
substantial
insights
into
anatomical,
molecular,
functional
heterogeneity
neurons.
Despite
this
wealth
new
knowledge,
it
remains
unclear
whether
how
diverse
features
defining
subclasses
converge
to
delineate
ensembles
within
system.
Here,
we
review
studies
investigating
various
aspects
discuss
development,
behavior,
disease
influence
subtype
characteristics.
We
then
outline
what
further
could
be
pursued
gain
more
inclusive
picture
diversity,
which
crucial
understanding
architecture
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Март 10, 2023
Abstract
The
reinforcing
nature
of
social
interactions
is
necessary
for
the
maintenance
appropriate
behavior.
However,
neural
substrates
underlying
reward
processing
and
how
they
might
differ
based
on
sex
internal
state
animal
remains
unknown.
It
also
unclear
whether
these
are
shared
with
those
involved
in
nonsocial
rewarding
processing.
We
developed
a
fully
automated,
novel
two
choice
(social-sucrose)
operant
assay
which
mice
choose
between
rewards
to
directly
compare
reward-related
behaviors
associated
competing
stimuli.
performed
cellular
resolution
calcium
imaging
medial
prefrontal
cortex
(mPFC)
neurons
male
female
across
varying
states
water
restriction
isolation.
found
that
mPFC
maintain
largely
non-overlapping,
flexible
representations
vary
sex-dependent
manner.
Additionally,
optogenetic
manipulation
activity
during
period
disrupted
reward-seeking
behavior
mice.
Thus,
using
assay,
we
have
identified
sex-dependent,
non-overlapping
essential
The
ability
to
distinguish
strangers
from
familiar
individuals
is
crucial
for
the
survival
of
most
mammalian
species.
In
humans,
an
inability
recognize
kin
and
engage
in
appropriate
behaviors
associated
with
several
types
dementia,
including
Alzheimer’s
disease.
Mice
preferentially
spend
more
time
investigating
a
novel
individual
relative
individual.
Yet,
how
social
novelty
related
information
drives
increased
investigation
animal
remains
poorly
understood.
Recent
evidence
has
implicated
ventral
hippocampus
(vHPC)
as
key
node
encoding
about
conspecific
identity.
Of
particular
interest
are
vHPC
projections
lateral
septum
(LS),
region
that
been
driving
wide
range
motivated
behaviors.
this
study
using
chemogenetics,
optogenetics
monosynaptic
rabies
tracing,
we
identified
vHPC-LS-ventral
tegmental
area
(VTA)
pathway
necessary
mice
investigate
conspecifics.
Using
established
LS
neurons
make
direct
connections
onto
dopaminergic
VTA.
Thus,
have
potential
via
which
identity
could
be
transformed
drive
