Dopamine Dynamics Underlying Alloparental Behavioral Acquisition Facilitated by Top-down Orbitofrontal Inputs in Female Mice

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 4, 2023

Abstract Maternal behaviors, which are crucial for the survival of mammalian infants, require coordinated operation multiple brain regions to process infant cues, make decisions, and execute motor plans. Although these processes likely demand higher cognitive functions, top-down regulation limbic parental programs remains poorly understood. Here, we show that orbitofrontal cortex (OFC) excitatory projection neurons promote alloparental caregiving behaviors in female mice. By chronic microendoscopy, observed robust yet adaptable representations pup-directed anticipatory motor-related activities within OFC significantly overlapped with those related nonsocial reward signals. The inactivation output reduced phasic midbrain dopamine (DA) specifically tied pup retrieval impaired modulation DA release ventral striatum during acquisition behaviors. Collectively, our study identifies signals from modulate plasticity system, thereby promoting Teaser Orbitofrontal facilitate virgin mice by modulating system.

Language: Английский

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Cell type specificity for circuit output in the midbrain dopaminergic system

Current Opinion in Neurobiology, Journal Year: 2023, Volume and Issue: 83, P. 102811 - 102811

Published: Nov. 14, 2023

Midbrain dopaminergic neurons are a relatively small group of in the mammalian brain controlling wide range behaviors. In recent years, increasingly sophisticated tracing, imaging, transcriptomic, and machine learning approaches have provided substantial insights into anatomical, molecular, functional heterogeneity neurons. Despite this wealth new knowledge, it remains unclear whether how diverse features defining subclasses converge to delineate ensembles within system. Here, we review studies investigating various aspects discuss development, behavior, disease influence subtype characteristics. We then outline what further could be pursued gain more inclusive picture diversity, which crucial understanding architecture

Language: Английский

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Sex differences in neural representations of social and nonsocial reward in the medial prefrontal cortex

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 10, 2023

Abstract The reinforcing nature of social interactions is necessary for the maintenance appropriate behavior. However, neural substrates underlying reward processing and how they might differ based on sex internal state animal remains unknown. It also unclear whether these are shared with those involved in nonsocial rewarding processing. We developed a fully automated, novel two choice (social-sucrose) operant assay which mice choose between rewards to directly compare reward-related behaviors associated competing stimuli. performed cellular resolution calcium imaging medial prefrontal cortex (mPFC) neurons male female across varying states water restriction isolation. found that mPFC maintain largely non-overlapping, flexible representations vary sex-dependent manner. Additionally, optogenetic manipulation activity during period disrupted reward-seeking behavior mice. Thus, using assay, we have identified sex-dependent, non-overlapping essential

Language: Английский

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A ventral hippocampal-lateral septum pathway regulates social novelty preference

Published: May 20, 2024

The ability to distinguish strangers from familiar individuals is crucial for the survival of most mammalian species. In humans, an inability recognize kin and engage in appropriate behaviors associated with several types dementia, including Alzheimer’s disease. Mice preferentially spend more time investigating a novel individual relative individual. Yet, how social novelty related information drives increased investigation animal remains poorly understood. Recent evidence has implicated ventral hippocampus (vHPC) as key node encoding about conspecific identity. Of particular interest are vHPC projections lateral septum (LS), region that been driving wide range motivated behaviors. this study using chemogenetics, optogenetics monosynaptic rabies tracing, we identified vHPC-LS-ventral tegmental area (VTA) pathway necessary mice investigate conspecifics. Using established LS neurons make direct connections onto dopaminergic VTA. Thus, have potential via which identity could be transformed drive

Language: Английский

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Mesocorticolimbic circuit mechanisms of social dominance behavior

Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(9), P. 1889 - 1899

Published: Sept. 2, 2024

Abstract Social animals, including rodents, primates, and humans, partake in competition for finite resources, thereby establishing social hierarchies wherein an individual’s standing influences diverse behaviors. Understanding the neurobiological underpinnings of dominance is imperative, given its ramifications health, survival, reproduction. behavior comprises several facets, recognition, decision-making, actions, indicating concerted involvement multiple brain regions orchestrating this behavior. While extensive research has been dedicated to elucidating neurobiology interaction, recent studies have increasingly delved into adverse behaviors such as hierarchy. This review focuses on latest advancements comprehending mechanisms mesocorticolimbic circuit governing dominance, with a specific focus rodent studies, intricate dynamics their implications individual well-being adaptation.

Language: Английский

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