Dopamine release after acute sleep deprivation: culprit of affective state transitions DOI Creative Commons

Ju Lan,

Zhong Chen, Heming Cheng

и другие.

MedComm, Год журнала: 2024, Номер 5(7)

Опубликована: Июль 1, 2024

Affective disorder is a prevalent chronic mental illness characterized by episodes of mania, depression, or alternating recurrent both. It associated with high suicide rate and low diagnosis rate, leading to severe functional impairments. The disruption sleep rhythm significant contributing factor in affective state transitions, but the underlying cellular neural circuit mechanisms remain poorly understood. In recent publication, Wu et al. developed an innovative mouse model automatic deprivation, unveiling that acute deprivation (SD) leads abnormal excitability distinct dopaminergic (DAergic) subsystems, thereby triggering transition manic-like reversal depression-like mice.1 Firstly, established SD integrating elevated platform rotating beam, effectively reducing both non-rapid eye movement rapid mice while minimizing stress compulsive motion (Figure 1A).1 They found normal exhibited heightened levels hyperactivity, aggression, sexual behavior following 12 h SD. However, this phenomenon reverted basal within 24–48 h, which highly likely restoration sleep-wake warrants further verification. addition, significantly ameliorated behaviors induced learned helplessness mice. Interestingly, antidepressant effect was sustained for at least 72 aligned clinical test.2 These findings indicate can induce hyperactive transformation reverse DAergic nervous system, as vital component ascending reticular plays crucial role essential physiological functions such regulation, emotional modulation, motor coordination.3 Moreover, alterations function circuits contribute various disorders including depression mania.4 precise mechanism system implicated disturbance be elucidated. Using calcium fiber photometry, observed remarkable increase activity neurons ventral tegmental area (VTA) during SD.1 Chemogenetic inhibition VTA not only reversed SD-induced hyperactivity aggressive also reduced attenuation depressive having no on behavior. suggest induces increased neurons, Increasing evidence indicates systems via downstream circuits. To investigate transmission different brain regions, used dopamine sensors monitor release nucleus accumbens (NAc), medial prefrontal cortex (mPFC), hypothalamus (HA), dorsal striatum (dStr).1 During SD, content NAc, mPFC, HA, change detected dStr. applied circuit-specific modulation evaluate their functions. Selectively VTA-NAc increases locomotion, selective VTA-mPFC effects. Intriguingly, VTA-HA counteracted elevation behavior, whereas VTA-dStr did exert any influence these aforementioned behaviors. demonstrate are mediated subsystems project targets. Furthermore, except dopamine, neuromodulators histamine serotonin play pivotal waking-promoting intricately involved regulation emotion. Therefore, investigating contribution transitions equally imperative. Alterations neuroplasticity mPFC closely depression. previously demonstrated ketamine enhances hyperplasia dendritic spines pyramidal receptor D1 (Drd1) receptors, exerting effects.5 wonder if results effects through similar mechanisms. By using Thy1-EGFP mice, they density deep 24 immediate enhancement probability glutamate-induced regeneration after Besides, conditional knockout Drd1 alteration spine regeneration. receptor-dependent neuronal plasticity mPFC. end, genetically encoded photoactivatable Rac1 (PaRac1) selectively eliminate recently activated synapses activating PaRac1 required Overall, mediates spines. inhibiting neonatal suggesting existence alternative conclusion, study demonstrates transmissions contributes diverse SD-associated 1B,C). addition affecting states, impact other cognition memory. This explore Ju Lan Heming Cheng wrote manuscript prepared figure. Zhong Chen provided valuable discussion modified manuscript. All authors have read approved final We appreciate Professor Yi Wang his support study. work supported National Natural Science Foundation China (82204353) Zhejiang Provincial (LY24H310002). declare conflict interest. Not applicable.

Язык: Английский

Paternal fenvalerate exposure causes depressive-like behaviour by altering Grb10 gene DNA methylation in adolescent offspring DOI Creative Commons
Huiru Chen, Tao Wang, Jing Shao

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 292, С. 117994 - 117994

Опубликована: Март 1, 2025

Fenvalerate, a typical pyrethroid pesticide, is neurological toxicant. This study aimed to evaluate the effect of paternal exposure fenvalerate on depressive-like behaviours in adolescent offspring. Depression-like behavior was determined by Sucrose Preference Test (SPT), Tail Suspension (TST) and Forced Swimming (FST) The level dopamine reduced midbrain fenvalerate-exposed Tyrosine hydroxylase (Th), rate limiting enzyme for synthesis, significantly offspring exposed fenvalerate. And Th decreased hindbrain fetuses Transcriptome analysis revealed growth factor receptor-bound protein 10 (Grb10) fetal Grb10 mRNA were Interestingly, vitro experiments, si-Grb10. Conversely, increased oe-Grb10. Mechanistically, 5mC content gene at one CpG fragment eighteen sites sperm In summary, causes altering DNA methylation sperm.

Язык: Английский

Процитировано

0
Sex and Sleep Quality Effects on the Relationship Between Sleep Disruption and Pain Sensitivity DOI Creative Commons

Elisabet Dortea Ragnvaldsdóttir Joensen,

Laura Frederiksen,

Signe Frederiksen

и другие.

European Journal of Pain, Год журнала: 2025, Номер 29(5)

Опубликована: Апрель 8, 2025

ABSTRACT Background Chronic pain affects around 20% of the global population and is influenced by various factors, including sleep quality. Studies indicate that disruption can enhance sensitivity; however, it unclear how sex baseline quality impact these findings. This study examines effects three nights on sensitivity in healthy individuals. Methods Fifty‐nine participants (30 females) underwent two laboratory sessions, separated disruption. Pain was measured using cuff handheld algometry, completed a battery questionnaires quality, positive negative affect, catastrophising. Sleep patterns were collected through wrist actigraphy self‐reported diaries. Results Temporal summation significantly facilitated males ( p < 0.01), during suprathreshold stimulation increased for females 0.01) after experimental No differences any QST parameters found when comparing with good or poor at baseline, but those rated as more painful 0.05) Finally, having associated significant reduction level rest 0.05). Conclusion indicates might sexes differently prior less likely to this. Significance protocols mimic problems experienced patients chronic pain. The current explains different respond 3‐night protocol results.

Язык: Английский

Процитировано

0
Gut microbiota: a new target for the prevention and treatment of insomnia using Chinese herbal medicines and their active components DOI Creative Commons

Chenxi Wu,

Jinjin Dou,

Xiaoxue Song

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Май 6, 2025

The emergence of the microbiota-gut-brain axis has opened new avenues for improving sleep quality. Recent studies have revealed a close relationship between insomnia and gut microbiome. Chinese herbal medicines their active components can alter relative abundance sleep-related microbiota by reversing dysbiosis in Improving quality through regulation using medicine its become highly promising therapeutic strategy. This article elucidates how modulates via intricate communication network gut-brain axis. It also reviews latest research on utilizing to regulate enhancing Additionally, it provides insights into potential modulation microbiota.

Язык: Английский

Процитировано

0
Acute sleep deprivation reduces fear memories in male and female mice DOI Creative Commons
Allison R. Foilb, Elisa M. Taylor-Yeremeeva,

Brett D. Schmidt

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Янв. 30, 2024

Sleep problems are a prominent feature of mental health conditions including post-traumatic stress disorder (PTSD). Despite its potential importance, the role sleep in development and/or recovery from trauma-related illnesses is not understood. Interestingly, there reports that deprivation immediately after traumatic experience can reduce fear memories, an effect could be utilized therapeutically humans. While mechanisms this completely understood, one possible explanation for these findings immediate interferes with consolidation rendering them weaker and more sensitive to intervention. Here, we allowed fear-conditioned mice conditioning during time frame (18 hr) includes extends beyond periods typically associated memory before subjecting 6 hr deprivation. Mice deprived delayed regimen showed dramatic reductions tests conducted deprivation, as well 24 later. This also increased levels mRNA encoding brain-derived neurotrophic factor (BDNF), molecule implicated neuroplasticity, basolateral amygdala (BLA), brain area extinction. These raise possibility effects our due disruption consolidation, but instead caused by BDNF-mediated neuroadaptations within BLA actively suppress expression fear. Treatments safely memories would have considerable therapeutic treatment triggered trauma.

Язык: Английский

Процитировано

3
Dopamine’s reach: Unlocked by sleep loss DOI Creative Commons
Bibi A. Sulaman,

Tyler Kudlak,

Ada Eban-Rothschild

и другие.

Neuron, Год журнала: 2024, Номер 112(1), С. 4 - 6

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

2
An overview of mechanisms underlying the comorbidity of sleep and depression disorders in the elderly DOI Creative Commons

Yuan Yao,

Dan Guo, Fanglin Liu

и другие.

Stress and Brain, Год журнала: 2024, Номер 4(1), С. 31 - 45

Опубликована: Март 1, 2024

Sleep disruption is common in older adults and has been linked to many negative health outcomes, including impaired cognitive, emotional, interpersonal functioning maladaptive metabolic changes. disturbance the most symptom depressive patients, it was formerly thought be a major secondary manifestation of depression. Many longitudinal studies have identified insomnia as an independent risk factor for development emerging or recurrent depression adults, with bidirectional relationships between sleep quality This narrative review summarizes recent research evidence on sleep–depression association well potential mechanisms underlying comorbidity disorders, focusing clock system, neurochemical substrates, neurocircuits. A better understanding pathophysiological can assist psychiatrists managing this comorbidity.

Язык: Английский

Процитировано

2
Dopamine Switches Affective States Under Acute Sleep Deprivation DOI

Zhou-Cai Luo,

Tianming Gao

Neuroscience Bulletin, Год журнала: 2024, Номер 40(8), С. 1205 - 1208

Опубликована: Май 9, 2024

Язык: Английский

Процитировано

2
Sleep maintains excitatory synapse diversity in the cortex and hippocampus DOI Creative Commons

Dimitra Koukaroudi,

Zhen Qiu, Erik Fransén

и другие.

Current Biology, Год журнала: 2024, Номер 34(16), С. 3836 - 3843.e5

Опубликована: Авг. 1, 2024

Insufficient sleep is a global problem with serious consequences for cognition and mental health.1Chattu V.K. Manzar M.D. Kumary S. Burman D. Spence D.W. Pandi-Perumal S.R. The Global Problem of Sleep Its Serious Public Health Implications.Healthcare (Basel). 2018; 71PubMed Google Scholar Synapses play central role in many aspects cognition, including the crucial function memory consolidation during sleep.2Brodt Inostroza M. Niethard N. Born J. Sleep—A brain-state serving systems consolidation.Neuron. 2023; 111: 1050-1075Abstract Full Text PDF PubMed Scopus (0) Interference normal expression or synapse proteins cause cognitive, mood, other behavioral problems over 130 brain disorders.3Bayes A. van de Lagemaat L.N. Collins M.O. Croning Whittle I.R. Choudhary J.S. Grant S.G. Characterization proteome, diseases evolution human postsynaptic density.Nat. Neurosci. 2011; 14: 19-21Crossref (353) deprivation (SD) has also been reported to alter protein composition number, although conflicting results.4Cirelli C. Tononi G. Effects waking on synaptic ultrastructure.Philos. Trans. R. Soc. Lond. B Biol. Sci. 2020; 37520190235Crossref (23) Scholar,5Havekes Aton S.J. Impacts Loss versus Waking Experience Brain Plasticity: Parallel Orthogonal?.Trends 43: 385-393Abstract (22) Scholar,6Puentes-Mestril Linking Network Activity Synaptic Plasticity Sleep: Hypotheses Recent Data.Front. Neural Circuits. 2017; 11: 61Crossref (85) Scholar,7Raven F. Van der Zee E.A. Meerlo P. Havekes regulating structural plasticity strength: implications cognitive function.Sleep Med. Rev. 39: 3-11Crossref (196) In our study, we conducted synaptome mapping excitatory synapses 125 regions mouse found that selectively reduces diversity cortex CA1 region hippocampus. targeted specific types subtypes while maintaining total density (synapse number/area). Synapse longer lifetimes exhibited resilience deprivation, similar observations aging genetic perturbations. Moreover, altered architecture affected responses neural oscillations, suggesting plays vital preserving by brain's architecture.

Язык: Английский

Процитировано

2
Adolescent sleep and its disruption in depression and anxiety DOI Creative Commons

Ruiming Chai,

Wen‐Jie Bian

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Ноя. 7, 2024

Adolescence is a pivotal stage during development when one’s personality, emotion, and behavioral traits are shaped to great extent, the underlying neural circuits undergo substantial developmental organizations. Dramatic dynamic changes occur in sleep architecture throughout postnatal course. Insufficient disruption of sleep/wake coherence prevalent among adolescents worldwide, even so young patients with neuropsychiatric conditions. Although accumulating evidence has suggested tight association between depression/anxiety, causal relationship remains largely unclear. More importantly, most these studies focused on adult subjects, little known about role mood behavior. Here we review recent investigating acute chronic effects adolescent depression anxiety both humans rodent models focuses assessment methodology age. By discussing findings unsolved problems, hope achieve better understanding mental health provide insights for future research.

Язык: Английский

Процитировано

2
LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons DOI Creative Commons
Chuyu Chen, Meghan Masotti, Nathaniel Shepard

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 8, 2024

Haloperidol is used to manage psychotic symptoms in several neurological disorders through mechanisms that involve antagonism of dopamine D2 receptors are highly expressed the striatum. Significant side effects haloperidol, known as extrapyramidal symptoms, lead motor deficits similar those seen Parkinson's disease and present a major challenge clinical settings. The underlying molecular responsible for these remain poorly understood. disease-associated LRRK2 kinase has an important role striatal physiology link receptor signaling. Here, we systematically explore convergent signaling haloperidol pharmacological or genetic inhibition kinase, well knock-in mouse models expressing pathogenic mutant with increased activity. Behavioral assays show ameliorates haloperidol-induced changes mice. A combination electrophysiological anatomical approaches reveals interferes changes, specifically neurons indirect pathway. Proteomic studies targeted intracellular pathway analyses demonstrate induces pattern Our study suggests plays key undesirable haloperidol. This work opens up new therapeutic avenues dopamine-related disorders, such psychosis, also furthering our understanding pathophysiology.

Язык: Английский

Процитировано

1