Adolescent-like Processing of Behaviorally Salient Cues in Sensory and Prefrontal Cortices of Adult Preterm-Born Mice DOI Creative Commons
Adema Ribic,

Emily McCoy,

Vyshnavi Pendala

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 11, 2024

Abstract Preterm birth is a leading risk factor for atypicalities in cognitive and sensory processing, but it unclear how prematurity impacts circuits that support these functions. To address this, we trained adult mice born day early (preterm mice) on visual discrimination task found they commit more errors fail to achieve high levels of performance. Using in vivo electrophysiology, the neurons primary cortex (V1) V1-projecting prefrontal anterior cingulate (ACC) are hyper-responsive reward, reminiscent cue processing adolescence. Moreover, non-rewarded fails robustly activate V1 ACC during error trials, contrast fast-spiking (FS) interneurons which show elevated error-related activity, suggesting preterm impairs function monitoring. Finally, environmental enrichment, well-established paradigm promotes maturation, failed improve performance mice, limited capacity interventions reducing deficits after birth. Altogether, our study first time identifies potential circuit mechanisms population highlights vulnerability advanced onset extrauterine experience.

Язык: Английский

Opioid use and abuse in adolescents and young adults; dealing with science, laws and ethics: Charming the COBRAS DOI

Donald E. Greydanus,

Ahsan Nazeer, Dilip R. Patel

и другие.

Disease-a-Month, Год журнала: 2025, Номер unknown, С. 101853 - 101853

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Development of Prefrontal Circuits and Cognitive Abilities DOI
Jastyn A. Pöpplau, Ileana L. Hanganu‐Opatz

Cold Spring Harbor Perspectives in Biology, Год журнала: 2024, Номер 16(10), С. a041502 - a041502

Опубликована: Май 1, 2024

The prefrontal cortex is considered as the site of multifaceted higher-order cognitive abilities. These abilities emerge late in life long after full sensorimotor maturation, line with protracted development circuits that has been identified on molecular, structural, and functional levels. Only recently, a result impressive methodological progress last several decades, mechanisms clinical implications have begun to be elucidated, yet major knowledge gaps still persist. Here, we provide an overview how develop enable processing at adulthood. First, review recent insights into circuit assembly, focus contribution early electrical activity. Second, highlight reorganization during adolescence. Finally, link plasticity specific developmental time windows mental health disorders discuss potential approaches for therapeutic interventions.

Язык: Английский

Процитировано

3
Excitatory and inhibitory synapses show a tight subcellular correlation that weakens over development DOI Creative Commons

Sally Horton,

Vincenzo Mastrolia, Rachel E. Jackson

и другие.

Cell Reports, Год журнала: 2024, Номер 43(7), С. 114361 - 114361

Опубликована: Июнь 18, 2024

Neurons receive correlated levels of excitation and inhibition, a feature that is important for proper brain function. However, how this relationship between excitatory inhibitory inputs established during the dynamic period circuit wiring remains unexplored. Using multiple techniques, including in utero electroporation, electron microscopy, electrophysiology, we reveal tight correlation distribution synapses along dendrites developing CA1 hippocampal neurons. This was present within short dendritic stretches (<20 μm) and, surprisingly, most pronounced early development, sharply declining with maturity. The matching inhibition unexpected, as lacked an active zone when formed exhibited compromised evoked release. We propose form stabilizing scaffold to counterbalance growing levels. diminishes over time, suggesting critical role subcellular balance neuronal function formation.

Язык: Английский

Процитировано

3
Trajectories of working memory and decision making abilities along juvenile development in mice DOI Creative Commons

Ann Marlene Thies,

Irina Pochinok, Annette Marquardt

и другие.

Frontiers in Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Фев. 28, 2025

Rodents commonly serve as model organisms for the investigation of human mental disorders by capitalizing on behavioral commonalities. However, our understanding developmental dynamics complex cognitive abilities in rodents remains incomplete. In this study, we examined spatial working memory well odor-and texture-based decision making mice using a delayed non-match to sample task and two-choice set-shifting task, respectively. Mice were investigated during different stages development: pre-juvenile, juvenile, young adult age. We show that, while improve with age, performance peaks juvenile age showing sex-independent trajectory. Moreover, cFos expression, first proxy neuronal activity, shows distinct age-and brain area-specific changes that relate task-specific performance. The trajectories resemble those previously reported humans.

Язык: Английский

Процитировано

0
Development of the rodent prefrontal cortex: circuit formation, plasticity, and impacts of early life stress DOI Creative Commons
Xinyi Chen, Yuri Kim, Daichi Kawaguchi

и другие.

Frontiers in Neural Circuits, Год журнала: 2025, Номер 19

Опубликована: Март 26, 2025

The prefrontal cortex (PFC), located at the anterior region of cerebral cortex, is a multimodal association essential for higher-order brain functions, including decision-making, attentional control, memory processing, and regulation social behavior. Structural, circuit-level, functional abnormalities in PFC are often associated with neurodevelopmental disorders. Here, we review recent findings on postnatal development PFC, particular emphasis rodent studies, to elucidate how its structural circuit properties established during critical developmental windows these processes influence adult behaviors. Recent evidence also highlights lasting effects early life stress structure, connectivity, function. We explore potential mechanisms underlying stress-induced alterations, focus epigenetic implications maturation By integrating insights, this provides an overview shaping their health disease.

Язык: Английский

Процитировано

0
Membrane progesterone and oestrogen receptors modulate GABAergic transmission in the prefrontal cortex of prepubertal male, but not female, mice DOI Creative Commons

Aitana Vázquez‐Sola,

Hortensia Torres‐Torrelo, Josue G. Yagüe

и другие.

Experimental Physiology, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

The sex hormones progesterone (P) and oestrogen (E) reorganize GABAergic transmission in the prefrontal cortex (PFC) during transition from childhood to adolescence, generating a new excitatory-inhibitory balance necessary for computational capacity of mature PFC. Little is known, however, about hormone receptors involved or whether there are differences modulation they exert. We hypothesize that P E can rapidly (within minutes) modulate currents through G protein-coupled receptors, namely membrane (mPRs) receptor (GPER), respectively, First, we quantified expression PFC using quantitative RT-PCR. Secondly, recorded synaptic (phasic) extrasynaptic (tonic) basal conditions response activation mPRs GPER patch-clamp recordings neurons prepubertal female male mice. Expression levels differed females males, but no were found phasic tonic between sexes. Interestingly, selective increased males not females, only males. also demonstrated exerted by was dependent on protein kinase A C. This study sheds light mechanisms which GPER.

Язык: Английский

Процитировано

0
Navigating Cultural Stress and Mental Health: A Longitudinal Study of Parent‐Adolescent Dynamics Among Former Soviet Union Families DOI
Aigerim Alpysbekova,

Seo Woo Lee,

Carolina Scaramutti

и другие.

Journal of Adolescence, Год журнала: 2025, Номер unknown

Опубликована: Май 23, 2025

Язык: Английский

Процитировано

0
Cells and molecules underpinning cannabis-related variations in cortical thickness during adolescence. DOI
Xavier Navarri, Derek N. Robertson,

Iness Charfi

и другие.

Journal of Neuroscience, Год журнала: 2024, Номер 44(41), С. e2256232024 - e2256232024

Опубликована: Авг. 30, 2024

During adolescence, cannabis experimentation is common, and its association with interindividual variations in brain maturation well studied. Cellular molecular underpinnings of these system-level relationships are, however, unclear. We thus conducted a three-step study. First, we exposed adolescent male mice to Δ-9-tetrahydrocannabinol (THC) or synthetic cannabinoid WIN 55,212-2 (WIN) assessed differentially expressed genes (DEGs), spine numbers, dendritic complexity their frontal cortex. Second, human (male) adolescents, examined group differences cortical thickness 34 regions, using magnetic resonance imaging, between those who experimented before age 16 (

Язык: Английский

Процитировано

2
Parallel maturation of rodent hippocampal memory and CA1 task representations DOI
Juraj Bevandić, Federico Stella, H. Freyja Ólafsdóttir

и другие.

Current Biology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

2
Peripuberty is a sensitive period for prefrontal parvalbumin interneuron activity to impact adult cognitive flexibility DOI Creative Commons

Gabriella M Sahyoun,

Trang Dao,

Amanda Anqueira-González

и другие.

Developmental Neuroscience, Год журнала: 2024, Номер unknown, С. 1 - 12

Опубликована: Июнь 3, 2024

Developmental windows in which experiences can elicit long-lasting effects on brain circuitry and behavior are called "sensitive periods" reflect a state of heightened plasticity. The classic example sensitive period comes from studies sensory systems, like the visual system, where early experience is required for normal wiring primary cortex proper functioning. At mechanistic level, loss incoming input results decrease activity thalamocortical neurons representing affected eye, resulting an activity-dependent reduction representation those inputs perception that eye. While associative cortical regions medial prefrontal (mPFC) do not receive direct input, recent findings demonstrate changes levels experienced by this region during defined development may also result circuitry, network function, behavior. For example, we recently demonstrated decreasing mPFC parvalbumin-expressing (PV) interneurons time encompassing peripuberty (postnatal day P14) to adolescence (P50) led their functional inhibition pyramidal cells, as well impairments cognitive flexibility. manipulating PV interneuron were selective development, adulthood, exact timing manipulation remains unknown.

Язык: Английский

Процитировано

1