Opioid use and abuse in adolescents and young adults; dealing with science, laws and ethics: Charming the COBRAS
Disease-a-Month,
Год журнала:
2025,
Номер
unknown, С. 101853 - 101853
Опубликована: Янв. 1, 2025
Язык: Английский
Trajectories of working memory and decision making abilities along juvenile development in mice
Frontiers in Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Фев. 28, 2025
Rodents
commonly
serve
as
model
organisms
for
the
investigation
of
human
mental
disorders
by
capitalizing
on
behavioral
commonalities.
However,
our
understanding
developmental
dynamics
complex
cognitive
abilities
in
rodents
remains
incomplete.
In
this
study,
we
examined
spatial
working
memory
well
odor-and
texture-based
decision
making
mice
using
a
delayed
non-match
to
sample
task
and
two-choice
set-shifting
task,
respectively.
Mice
were
investigated
during
different
stages
development:
pre-juvenile,
juvenile,
young
adult
age.
We
show
that,
while
improve
with
age,
performance
peaks
juvenile
age
showing
sex-independent
trajectory.
Moreover,
cFos
expression,
first
proxy
neuronal
activity,
shows
distinct
age-and
brain
area-specific
changes
that
relate
task-specific
performance.
The
trajectories
resemble
those
previously
reported
humans.
Язык: Английский
Characterizing Large-Scale Human Circuit Development with In Vivo Neuroimaging
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2024,
Номер
16(6), С. a041496 - a041496
Опубликована: Март 4, 2024
Tomoki
Arichi1,2,3
1Centre
for
the
Developing
Brain,
School
of
Biomedical
Engineering
and
Imaging
Sciences,
King's
College
London,
St
Thomas'
Hospital,
London
SE1
7EH,
United
Kingdom
2MRC
Centre
Neurodevelopmental
Disorders,
New
Hunt's
House,
Guy's
Campus,
1UL,
3Children's
Neurosciences,
Evelina
Children's
NHS
Foundation
Trust,
Correspondence:
tomoki.arichi{at}kcl.ac.uk
Язык: Английский