Intuitive Human–Artificial Intelligence Theranostic Complementarity

Cancer Biotherapy and Radiopharmaceuticals, Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

Deep learning artificial intelligence (AI) algorithms are poised to subsume diagnostic imaging specialists in radiology and nuclear medicine, where radiomics can consistently outperform human analysis reporting capability, do it faster, with greater accuracy reliability. However, claims made for generative AI respect of decision-making the clinical practice theranostic medicine highly contentious. Statistical computer cannot emulate emotion, reason, instinct, intuition, or empathy. simulates without possessing it. has no understanding meaning its outputs. The unique statistical probability attributes large language models must be complemented by innate intuitive capabilities physicians who accept responsibility accountability direct care each individual patient referred management specified cancers. Complementarity envisions synergistic engagement radiomics, genomics, radiobiology, dosimetry, data collation from multidimensional sources, including electronic medical record, enable physician spend informed face time their patient. Together discernment, application technical insights will facilitate optimal formulation a personalized precision strategy empathic, efficacious, targeted treatment cancer accordance wishes.

Язык: Английский

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Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouse’s hand

Опубликована: Май 2, 2025

Spiking activity along synaptic circuits linking primary somatosensory (S1) and motor (M1) areas is fundamental for sensorimotor integration in cortex. Circuits the ascending pathway through mouse hand/forelimb S1 M1 were recently described detail (Yamawaki et al., 2021). Here, we characterize peripherally evoked spiking dynamics these two cortical areas. Brief (5 ms) optogenetic photostimulation of hand generated short (∼25 barrages first (onset latency 15 then (10 ms later). The estimated propagation speed was 20-fold faster from to than M1. Amplitudes strongly attenuated. Responses typically triphasic, with suppression rebound following initial peak. Evoked biased middle layers, consistent thalamocortical connectivity, while that upper corticocortical connectivity. Parvalbumin (PV) inhibitory interneurons involved each phase, accounting three quarters spikes S1, their selective sufficed evoke both Partial silencing by PV activation during stimulation reduced sensory responses. Overall, results how propagates transcortical loop, illuminate vivo relate underlying circuit organization this system.

Язык: Английский

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Exploratory Homiletical Perspectives on the Influence of AI and GAI on People’s Cognition and Reasoning About Warfare in the Era of Homo Digitalis

Religions, Год журнала: 2025, Номер 16(2), С. 251 - 251

Опубликована: Фев. 17, 2025

Cognitive warfare is a matter of concern due to its impact on people’s minds and decision-making. The manifestation wars the deliberate attempts nations use AI technologies their advantage in outsmarting cannot be ignored from homiletical perspective. This article argues that (Artificial Intelligence), GAI (Generative Artificial ChatGPT Pre-trained Transformer) offer tremendous possibilities enhance interplay with humans. Viewed through lenses philosophy ethics, it becomes evident people providing data engage technology an intrinsic worldview. provision information decision-making prompts us consider reasoning responsibility. harmful consequences killer robots facial recognition reach human targets raise deep ethical questions. author contends listeners sermons are exposed age homo digitalis tasked making sense what happening world. When praxeology remains silent injustices undignified practices cognitive drone use, without proclaiming values gospel Kingdom, become reliant alternative sources information. In normative section this article, importance demolishing arguments pretensions oppose knowledge God taking every thought captive make obedient God’s will emphasised. concludes call for homiletics rather than ignore them. By utilising technological advantages undermining paramount value preaching within unique contexts faith communities, may more open experience transformation minds, particularly regarding warfare.

Язык: Английский

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Integrated Information Theory and the Phenomenal Binding Problem: Challenges and Solutions in a Dynamic Framework

Entropy, Год журнала: 2025, Номер 27(4), С. 338 - 338

Опубликована: Март 25, 2025

Theories of consciousness grounded in neuroscience must explain the phenomenal binding problem, e.g., how micro-units information are combined to create macro-scale conscious experience common human phenomenology. An example is single ‘pixels’ a visual scene experienced as holistic image ‘mind’s eye’, rather than individual, separate, and massively parallel experiences, corresponding perhaps individual neuron activations, neural ensembles, or foveal saccades, any which could conceivably deliver identical functionality from an processing point view. There multiple contested candidate solutions problem. This paper explores metaphysical infrastructure Integrated Information Theory (IIT) v4.0 can provide distinctive solution. The solution—that particular entities aggregable units (‘complexes’) define existence—might work static picture, but introduces issues dynamic system. We ask what happens our self main complex moves around biological network. Our account developing through time leads apparent dilemma for IIT theorists between non-local entity transitions contiguous selves: ‘dynamic evolution problem’. As well specifying dilemma, we describe three ways might dissolve before it gains traction. Clarifying IIT’s position on potentially underpinned with novel empirical theoretical research, helps researchers understand assess its plausibility. see contributing current research emphasis shift analysis.

Язык: Английский

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Preference-independent saliency map in the mouse superior colliculus

Communications Biology, Год журнала: 2025, Номер 8(1)

Опубликована: Апрель 4, 2025

Detecting salient stimuli in a visual scene is crucial for animal survival, yet how the brain encodes saliency remains unclear. Here, using two-photon calcium imaging, we reveal preference-independent map superficial superior colliculus of awake mice. Salient evoke stronger responses than uniform both excitatory and inhibitory neurons, with similar encoding patterns across cell types. The strongest response occurs when stimulus centered within receptive field, contextual effects extending approximately 40°. Response amplitude scales strength but independent neurons' orientation or motion direction preferences. Notably, saliency-encoding neurons exhibit weak selectivity, indicating complementary relationship between feature maps. Importantly, this does not require cortical inputs. These findings provide insights into neural mechanisms underlying detection.

Язык: Английский

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A Wireless Self-Fine-Tuning Artificial Neural Pathway Implant for Near-Real-Time Close-Loop Motor Modulation

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Artificial neural pathway (ANP) implants hold transformative potential for empowering individuals with disabilities, which has recently revolutionized the clinical treatment of spinal cord injury through epidural electrical stimulation (EES). Classical EES operates a pre-set program and needs manual modification, consuming both manpower time. Although existed studies proposed kinematic image processing to configurate or brain-spine interface control motions automatically, prompt tuning on motor modulation in an open environment is still inaccessible. Here, we show wireless self-fine-tuning ANP implant establish rapid self-feedback mechanism appropriate free activities achieve precise by EES. The fine-tuning was attached writing using implanted bidirectional featuring compact size, low input noise, high energy efficiency, different functionalities including reading, writing, control. sciatic signals are fed into as feedback self tuning. Without interventions, restored gaits hindlegs paralyzed animals self-fine-tuning, near-real-time, close-loop mechanism.

Язык: Английский

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Persistent interaction: A conceptualization of user-generated artefacts in Visual Analytics

Computers & Graphics, Год журнала: 2025, Номер unknown, С. 104232 - 104232

Опубликована: Май 1, 2025

Язык: Английский

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