У
многих
пациентов
после
перенесенной
коронавирусной
инфекции,
помимо
характерного
постинфекционного
астенического
синдрома,
развивается
комплекс
когнитивных
расстройств
с
преобладанием
нарушений
исполнительских
функций
и
кратковременной
памяти,
иногда
в
виде
ощущений
«мозгового
тумана».
Эти
нарушения
встречаются
у
значительного
числа
переболевших,
имеют
неоднородную
структуру,
комплексный
механизм
отличаются
длительным
персистирующим
характером.
Их
особенность
заключается
отсутствии
четкой
взаимосвязи
симптомами
круга,
значительной
распространенности
по
сравнению
другими
постинфекционными
нарушениями
требует
разработки
унифицированных
подходов
к
их
оценке
учетом
индивидуальных
особенностей
пациентов.
Существует
потребность
продолжении
масштабных
исследований,
посвященных
оптимизации
комплексной
нейрореабилитации
постковидными
расстройствами,
эффективности
безопасности
потенциально
эффективных
средств
восстановления
стимуляции
функций.
средства
должны
влиять
на
механизмы
системного
воспаления,
гемореологические
параметры
оказывать
благоприятные
нейропротекторные
эффекты.
Остается
актуальным
вопрос
индивидуализированного
прогноза
профилактики
последствий
инфекции.
Many
patients
after
the
COVID-19
infection,
in
addition
to
postinfectious
asthenia,
develop
a
complex
of
cognitive
disorders
with
predominance
impaired
executive
functions
and
short-term
memory,
sometimes
form
"brain
fog".
Cognitive
impairment
occurs
significant
number
patients.
They
have
heterogeneous
structure
mechanism,
usually
characterized
by
long-term
persistence.
Their
specific
features
are
lack
clear
relationship
symptoms
as
well
prevalence
compared
other
post-infectious
disorders.
All
this
requires
development
unified
approaches
their
assessment,
considering
individual
characteristics
There
is
need
continue
large-scale
studies
optimize
neurorehabilitation
post-COVID-19
disorders,
evaluate
efficacy
safety
potentially
effective
therapeutic
agents
for
restoration
stimulation
functions.
These
pharmacological
should
control
mechanisms
systemic
inflammation,
hemorheological
parameters
provide
favorable
neuroprotective
effects.
The
individualized
prognosis
prevention
consequences
coronavirus
infection
remains
an
important
problem.
Journal of Personalized Medicine,
Год журнала:
2022,
Номер
12(12), С. 2070 - 2070
Опубликована: Дек. 15, 2022
The
present
study
aims
to
provide
a
critical
overview
of
the
literature
on
relationships
between
post-acute
COVID-19
infection
and
cognitive
impairment,
highlighting
limitations
confounding
factors.
A
systematic
search
articles
published
from
1
January
2020
July
2022
was
performed
in
PubMed/Medline.
We
followed
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analyses
(PRISMA)
guidelines.
Only
studies
using
validated
instruments
assessment
impairment
were
included.
Out
5515
screened
records,
72
met
inclusion
criteria.
available
evidence
revealed
presence
executive
functions,
speed
processing,
attention
memory
subjects
recovered
COVID-19.
However,
several
reviewed
should
be
highlighted:
most
small
samples,
not
stratified
by
severity
disease
age,
used
as
cross-sectional
or
short-term
longitudinal
design
provided
limited
different
domains.
Few
investigated
neurobiological
correlates
deficits
individuals
Further
with
an
adequate
methodological
are
needed
in-depth
characterization
International Journal of Environmental Research and Public Health,
Год журнала:
2023,
Номер
20(6), С. 5061 - 5061
Опубликована: Март 13, 2023
The
global
coronavirus
pandemic
has
significantly
impacted
public
health
and
been
a
research
subject
since
its
emergence
in
2019.
acute
phase
of
the
disease
leads
to
pulmonary
non-pulmonary
manifestations,
which
some
individuals
may
progress
long-lasting
symptoms.
In
this
article,
we
conducted
narrative
review
current
literature
summarize
knowledge
regarding
long
COVID
syndrome
children,
focusing
on
cognitive
included
search
three
databases
(PubMed,
Embase,
Web
Science)
using
key
phrases
“post
COVID-19
pediatric”,
“long
“mental
children”,
“COVID-19
symptoms”.
A
total
102
studies
were
included.
revealed
that
main
long-term
symptoms
following
memory
concentration
deficits,
sleep
disturbances,
psychiatric
states
such
as
anxiety
stress.
addition
direct
physiological
effects
viral
infection,
there
are
psychological,
behavioral,
social
factors
contributing
impairment,
should
be
addressed
pediatric
population.
high
prevalence
neurocognitive
children
emphasizes
importance
understanding
mechanisms
nervous
system
involvement.
Sensors,
Год журнала:
2022,
Номер
22(17), С. 6606 - 6606
Опубликована: Сен. 1, 2022
Previous
research
and
clinical
reports
have
shown
that
some
individuals
after
COVID-19
infection
may
demonstrate
symptoms
of
so-called
brain
fog,
manifested
by
cognitive
impairment
disorganization
in
behavior.
Meanwhile,
several
other
conditions,
related
to
intellectual
function,
a
specific
pattern
changes
electric
activity,
as
recorded
quantitative
electroencephalography
(QEEG)
has
been
documented.
We
hypothesized,
post-COVID
the
subjective
complaints
be
accompanied
objective
QEEG
profile.
In
order
test
this
hypothesis,
we
performed
an
exploratory
study
on
academic
staff
our
University
with
previous
records
originating
pre-COVID-19
era.
Among
them,
20
subjects
who
revealed
neurological
problems
sphere
(confirmed
covid
fog/brain
fog
specialist)
were
identified.
those
individuals,
was
performed.
observed,
opposite
baseline
records,
increased
Theta
Alpha
well
more
intensive
sensimotor
rhythm
(SMR)
C4
(right
hemisphere)
relation
C3
(left
hemisphere).
Moreover,
visible
increase
Beta
2
SMR
both
hemispheres
could
Summarizing,
clear
change
activity
patterns
previously
not
affected
now
suffering
from
post-COVID-19
fog.
These
preliminary
results
warrant
further
interest
delineating
their
background.
Here,
neuroinflammation
psychological
stress,
Sars-CoV2-infection
considered.
Based
observation,
relevance
examination
supportive
tool
for
workup
monitoring
treatment
effects
is
also
explored.
Brain and Behavior,
Год журнала:
2023,
Номер
13(4)
Опубликована: Фев. 21, 2023
To
characterize
the
cognitive
profile
following
COVID-19
infection
and
its
possible
association
to
clinical
symptoms,
emotional
disturbance,
biomarkers,
disease
severity.
Viruses,
Год журнала:
2023,
Номер
15(4), С. 908 - 908
Опубликована: Март 31, 2023
Background:
There
is
an
urgent
need
to
better
understand
the
mechanisms
underlying
acute
and
long-term
neurological
symptoms
after
COVID-19.
Neuropathological
studies
can
contribute
a
understanding
of
some
these
mechanisms.
Methods:
We
conducted
detailed
postmortem
neuropathological
analysis
32
patients
who
died
due
COVID-19
during
2020
2021
in
Austria.
Results:
All
cases
showed
diffuse
white
matter
damage
with
microglial
activation
variable
severity,
including
one
case
hemorrhagic
leukoencephalopathy.
Some
revealed
mild
inflammatory
changes,
olfactory
neuritis
(25%),
nodular
brainstem
encephalitis
(31%),
cranial
nerve
(6%),
which
were
similar
those
observed
non-COVID-19
severely
ill
patients.
One
previously
immunosuppressed
patient
developed
herpes
simplex
encephalitis.
Acute
vascular
pathologies
(acute
infarcts
22%,
thrombosis
12%,
hypoxic–ischemic
brain
40%)
pre-existing
small
vessel
diseases
(34%)
frequent
findings.
Moreover,
silent
neurodegenerative
elderly
persons
common
(AD
neuropathologic
changes
32%,
age-related
neuronal
glial
tau
Lewy
bodies
9%,
argyrophilic
grain
disease
12.5%,
TDP43
pathology
6%).
Conclusions:
Our
results
support
previous
findings
apparently
multifactorial
most
likely
indirect
context
SARS-CoV-2
infection
rather
than
virus-specific
damage,
they
are
line
recent
experimental
data
on
SARS-CoV-2-related
activation,
cytokine
release.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июнь 5, 2024
Abstract
We
aimed
to
characterize
the
cognitive
profile
of
post-acute
COVID-19
syndrome
(PACS)
patients
with
complaints,
exploring
influence
biological
and
psychological
factors.
Participants
confirmed
SARS-CoV-2
infection
complaints
≥
8
weeks
phase
were
included.
A
comprehensive
neuropsychological
battery
(NPS)
health
questionnaires
administered
at
inclusion
1,
3
6
months.
Blood
samples
collected
each
visit,
MRI
scan
baseline
months,
and,
optionally,
cerebrospinal
fluid.
Cognitive
features
analyzed
in
relation
clinical,
neuroimaging,
biochemical
markers
follow-up.
Forty-nine
participants,
a
mean
time
from
symptom
onset
10.4
showed
attention-executive
function
(69%)
verbal
memory
(39%)
impairment.
Apathy
(64%),
moderate-severe
anxiety
(57%),
severe
fatigue
(35%)
prevalent.
Visual
(8%)
correlated
total
gray
matter
(GM)
subcortical
GM
volume.
Neuronal
damage
inflammation
within
normal
limits.
Over
time,
test
scores,
depression,
apathy,
indexes,
fluid
biomarkers
remained
stable,
although
fewer
participants
(50%
vs.
75.5%;
p
=
0.012)
exhibited
abnormal
evaluations
Altered
attention/executive
memory,
common
PACS,
persisted
most
subjects
without
association
structural
abnormalities,
elevated
cytokines,
or
neuronal
markers.
Clinical Autonomic Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 22, 2025
Abstract
Purpose
The
aim
of
the
study
is
to
analyze
and
compare
cognitive
profile
between
59
patients
with
long-COVID
[LC;
30
them
29
without
a
positive
coronavirus
disease
2019
(COVID-19)
confirmatory
test]
31
postural
orthostatic
tachycardia
syndrome
(POTS)
matched
group
39
healthy
control
participants.
Methods
Participants
were
examined
on
battery
neuropsychological
tests,
including
verbal
memory,
visuospatial
abilities,
attention,
processing
speed,
fluency,
working
visual
memory.
Anxious–depressive
symptomatology
was
also
analyzed
then
controlled
for
possible
influence
performance.
Results
Patients
LC
POTS
showed
significantly
lower
performance
compared
peers.
Differences
anxious
depressive
symptoms
found
clinical
groups,
resulting
in
test
exhibiting
highest
rates
symptoms.
After
controlling
effects
anxious–depressive
symptomatology,
differences
eliminated
some
variables,
but
additional
after
post
hoc
analysis.
Conclusions
Findings
from
present
contribute
toward
reinforcement
evidence
alterations
associated
POTS.
has
be
considered
both
groups
since
it
could
affecting