Brain fog as a Long-term Sequela of COVID-19

SN Comprehensive Clinical Medicine, Год журнала: 2022, Номер 5(1)

Опубликована: Ноя. 24, 2022

Язык: Английский

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Cognitive Impairment after Post-Acute COVID-19 Infection: A Systematic Review of the Literature

Journal of Personalized Medicine, Год журнала: 2022, Номер 12(12), С. 2070 - 2070

Опубликована: Дек. 15, 2022

The present study aims to provide a critical overview of the literature on relationships between post-acute COVID-19 infection and cognitive impairment, highlighting limitations confounding factors. A systematic search articles published from 1 January 2020 July 2022 was performed in PubMed/Medline. We followed Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. Only studies using validated instruments assessment impairment were included. Out 5515 screened records, 72 met inclusion criteria. available evidence revealed presence executive functions, speed processing, attention memory subjects recovered COVID-19. However, several reviewed should be highlighted: most small samples, not stratified by severity disease age, used as cross-sectional or short-term longitudinal design provided limited different domains. Few investigated neurobiological correlates deficits individuals Further with an adequate methodological are needed in-depth characterization

Язык: Английский

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Cognition and Mental Health in Pediatric Patients Following COVID-19

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(6), С. 5061 - 5061

Опубликована: Март 13, 2023

The global coronavirus pandemic has significantly impacted public health and been a research subject since its emergence in 2019. acute phase of the disease leads to pulmonary non-pulmonary manifestations, which some individuals may progress long-lasting symptoms. In this article, we conducted narrative review current literature summarize knowledge regarding long COVID syndrome children, focusing on cognitive included search three databases (PubMed, Embase, Web Science) using key phrases “post COVID-19 pediatric”, “long “mental children”, “COVID-19 symptoms”. A total 102 studies were included. revealed that main long-term symptoms following memory concentration deficits, sleep disturbances, psychiatric states such as anxiety stress. addition direct physiological effects viral infection, there are psychological, behavioral, social factors contributing impairment, should be addressed pediatric population. high prevalence neurocognitive children emphasizes importance understanding mechanisms nervous system involvement.

Язык: Английский

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Comparison of QEEG Findings before and after Onset of Post-COVID-19 Brain Fog Symptoms

Sensors, Год журнала: 2022, Номер 22(17), С. 6606 - 6606

Опубликована: Сен. 1, 2022

Previous research and clinical reports have shown that some individuals after COVID-19 infection may demonstrate symptoms of so-called brain fog, manifested by cognitive impairment disorganization in behavior. Meanwhile, several other conditions, related to intellectual function, a specific pattern changes electric activity, as recorded quantitative electroencephalography (QEEG) has been documented. We hypothesized, post-COVID the subjective complaints be accompanied objective QEEG profile. In order test this hypothesis, we performed an exploratory study on academic staff our University with previous records originating pre-COVID-19 era. Among them, 20 subjects who revealed neurological problems sphere (confirmed covid fog/brain fog specialist) were identified. those individuals, was performed. observed, opposite baseline records, increased Theta Alpha well more intensive sensimotor rhythm (SMR) C4 (right hemisphere) relation C3 (left hemisphere). Moreover, visible increase Beta 2 SMR both hemispheres could Summarizing, clear change activity patterns previously not affected now suffering from post-COVID-19 fog. These preliminary results warrant further interest delineating their background. Here, neuroinflammation psychological stress, Sars-CoV2-infection considered. Based observation, relevance examination supportive tool for workup monitoring treatment effects is also explored.

Язык: Английский

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Impact of COVID‐19 infection on cognition and its association with neurological symptoms

Brain and Behavior, Год журнала: 2023, Номер 13(4)

Опубликована: Фев. 21, 2023

To characterize the cognitive profile following COVID-19 infection and its possible association to clinical symptoms, emotional disturbance, biomarkers, disease severity.

Язык: Английский

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Multifactorial White Matter Damage in the Acute Phase and Pre-Existing Conditions May Drive Cognitive Dysfunction after SARS-CoV-2 Infection: Neuropathology-Based Evidence

Viruses, Год журнала: 2023, Номер 15(4), С. 908 - 908

Опубликована: Март 31, 2023

Background: There is an urgent need to better understand the mechanisms underlying acute and long-term neurological symptoms after COVID-19. Neuropathological studies can contribute a understanding of some these mechanisms. Methods: We conducted detailed postmortem neuropathological analysis 32 patients who died due COVID-19 during 2020 2021 in Austria. Results: All cases showed diffuse white matter damage with microglial activation variable severity, including one case hemorrhagic leukoencephalopathy. Some revealed mild inflammatory changes, olfactory neuritis (25%), nodular brainstem encephalitis (31%), cranial nerve (6%), which were similar those observed non-COVID-19 severely ill patients. One previously immunosuppressed patient developed herpes simplex encephalitis. Acute vascular pathologies (acute infarcts 22%, thrombosis 12%, hypoxic–ischemic brain 40%) pre-existing small vessel diseases (34%) frequent findings. Moreover, silent neurodegenerative elderly persons common (AD neuropathologic changes 32%, age-related neuronal glial tau Lewy bodies 9%, argyrophilic grain disease 12.5%, TDP43 pathology 6%). Conclusions: Our results support previous findings apparently multifactorial most likely indirect context SARS-CoV-2 infection rather than virus-specific damage, they are line recent experimental data on SARS-CoV-2-related activation, cytokine release.

Язык: Английский

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Cognitive profile, neuroimaging and fluid biomarkers in post-acute COVID-19 syndrome

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июнь 5, 2024

Abstract We aimed to characterize the cognitive profile of post-acute COVID-19 syndrome (PACS) patients with complaints, exploring influence biological and psychological factors. Participants confirmed SARS-CoV-2 infection complaints ≥ 8 weeks phase were included. A comprehensive neuropsychological battery (NPS) health questionnaires administered at inclusion 1, 3 6 months. Blood samples collected each visit, MRI scan baseline months, and, optionally, cerebrospinal fluid. Cognitive features analyzed in relation clinical, neuroimaging, biochemical markers follow-up. Forty-nine participants, a mean time from symptom onset 10.4 showed attention-executive function (69%) verbal memory (39%) impairment. Apathy (64%), moderate-severe anxiety (57%), severe fatigue (35%) prevalent. Visual (8%) correlated total gray matter (GM) subcortical GM volume. Neuronal damage inflammation within normal limits. Over time, test scores, depression, apathy, indexes, fluid biomarkers remained stable, although fewer participants (50% vs. 75.5%; p = 0.012) exhibited abnormal evaluations Altered attention/executive memory, common PACS, persisted most subjects without association structural abnormalities, elevated cytokines, or neuronal markers.

Язык: Английский

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Cognitive dysfunction, diabetes mellitus 2 and arterial hypertension: Sequelae up to one year of COVID-19

Travel Medicine and Infectious Disease, Год журнала: 2023, Номер 52, С. 102553 - 102553

Опубликована: Март 1, 2023

Covid symptoms reflect its multisystem nature, in addition to positive relationship between the severity of condition and long COVID.

Язык: Английский

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The effect of donepezil hydrochloride on post-COVID memory impairment: A randomized controlled trial

Journal of Clinical Neuroscience, Год журнала: 2023, Номер 118, С. 168 - 174

Опубликована: Ноя. 10, 2023

Язык: Английский

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Long-COVID and postural orthostatic tachycardia syndrome: a preliminary comparison of neuropsychological performance

Clinical Autonomic Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Abstract Purpose The aim of the study is to analyze and compare cognitive profile between 59 patients with long-COVID [LC; 30 them 29 without a positive coronavirus disease 2019 (COVID-19) confirmatory test] 31 postural orthostatic tachycardia syndrome (POTS) matched group 39 healthy control participants. Methods Participants were examined on battery neuropsychological tests, including verbal memory, visuospatial abilities, attention, processing speed, fluency, working visual memory. Anxious–depressive symptomatology was also analyzed then controlled for possible influence performance. Results Patients LC POTS showed significantly lower performance compared peers. Differences anxious depressive symptoms found clinical groups, resulting in test exhibiting highest rates symptoms. After controlling effects anxious–depressive symptomatology, differences eliminated some variables, but additional after post hoc analysis. Conclusions Findings from present contribute toward reinforcement evidence alterations associated POTS. has be considered both groups since it could affecting

Язык: Английский

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