The cerebellum and the Mirror Neuron System: A matter of inhibition? From neurophysiological evidence to neuromodulatory implications. A narrative review
Neuroscience & Biobehavioral Reviews,
Год журнала:
2024,
Номер
164, С. 105830 - 105830
Опубликована: Июль 26, 2024
Mirror
neurons
show
activity
during
both
the
execution
(AE)
and
observation
of
actions
(AO).
The
Neuron
System
(MNS)
could
be
involved
motor
imagery
(MI)
as
well.
Extensive
research
suggests
that
cerebellum
is
interconnected
with
MNS
may
critically
in
its
activities.
We
gathered
evidence
on
cerebellum's
role
functions,
theoretically
experimentally.
Evidence
shows
plays
a
major
AO
MI
lesions
impair
functions
likely
because,
by
modulating
cortical
inhibitory
interneurons
mirror
properties,
contribute
to
visuomotor
matching,
which
fundamental
for
shaping
properties.
Indeed,
strengthen
sensory-motor
patterns
minimise
discrepancy
between
predicted
actual
outcome,
AE
AO.
Furthermore,
through
connections
hippocampus,
might
internal
simulations
programs
MI.
Finally,
cerebellar
neuromodulation
improve
impact
activity,
we
explored
potential
neurophysiological
neurorehabilitation
implications.
Язык: Английский
Establishing functionally segregated dopaminergic circuits
Trends in Neurosciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Impaired metabotropic glutamate type 5 receptor signaling in the dorsal striatum of the R451C-neuroligin 3 mouse model of Autism Spectrum Disorder
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Abstract
Human
genetics
indicates
enrichment
of
synaptic
pathway-related
mutations
in
Autism
Spectrum
Disorder
(ASD).
Accordingly,
several
preclinical
studies
have
reported
alterations
different
brain
areas
relevant
ASD
mouse
models.
In
particular,
we
previously
showed
that
corticostriatal
long-term
depression
is
impaired
the
dorsal
striatum
mice
carrying
ASD-associated
R451C
mutation
NL3
gene,
coding
for
postsynaptic
protein
neuroligin
3.
Here,
used
behavioral,
proteomic,
biochemical,
and
electrophysiological
approaches
to
explore
striatum-dependent
functions
R451C-NL3
knock-in
model
ASD.
A
detailed
behavioral
analysis
confirmed
these
mice.
We
further
explored
function
striatum,
disclosing
modifications
glutamatergic
density
composition
impairment
forms
plasticity
involving
activation
group
I
metabotropic
glutamate
receptors,
namely
activity-dependent
potentiation,
pharmacological
3,5-DHPG-induced
depression.
Notably,
receptors
was
not
able
potentiate
NMDA
receptor-mediated
currents.
Protein
expression
levels
type
5
receptor
were
reduced
at
striatal
synapses,
whereas
level
ionotropic
unaltered.
Overall,
our
findings
point
a
significant
signaling
3
mice,
affecting
circuitry,
has
been
implicated
autism-related
behaviors.
Язык: Английский
Impaired metabotropic glutamate type 5 receptor signaling in the dorsal striatum of the R451C-neuroligin 3 mouse model of Autism Spectrum Disorder
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 16, 2024
Abstract
Background
Human
genetics
indicates
enrichment
of
synaptic
pathway-related
mutations
in
Autism
Spectrum
Disorder
(ASD).
Accordingly,
several
preclinical
studies
have
reported
alterations
different
brain
areas
relevant
ASD
mouse
models.
In
particular,
we
previously
showed
that
corticostriatal
long-term
depression
is
impaired
the
dorsal
striatum
mice
carrying
ASD-associated
R451C
mutation
neuroligin3
gene.
Methods
We
used
behavioral,
proteomic,
biochemical,
and
electrophysiological
approaches
to
explore
striatum-dependent
functions
R451C-neuroligin3
model
ASD.
Results
A
detailed
behavioral
analysis
confirmed
these
mice.
further
explored
function,
disclosing
modifications
glutamatergic
postsynaptic
density
protein
composition,
which
functionally
result
impairment
forms
plasticity,
namely
activity-dependent
potentiation,
group
I
metabotropic
glutamate
receptor-dependent
depression.
also
found
reduced
expression
levels
type
5
receptor
at
striatal
synapses,
likely
preclude
potentiation
by
preventing
NMDA
receptor-mediated
currents
a
sufficient
generation
endocannabinoids,
respectively.
Conclusions
Overall,
our
findings
point
significant
signaling,
affecting
underlies
specific
autism-relevant
behaviors
Язык: Английский
Sex and estradiol effects in the rodent dorsal striatum
European Journal of Neuroscience,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 21, 2024
Abstract
17β‐Estradiol
(E2)
is
a
sex
hormone
that
acts
on
many
brain
regions
to
produce
changes
in
neuronal
activity
and
learning.
A
key
region
sensitive
E2
the
dorsal
striatum
(also
called
caudate‐putamen),
which
controls
motor
behaviour,
goal‐directed
learning
habit
In
adult
rodents,
oestrogen
receptors
(ERs)
are
localized
plasma
membrane
include
ERα,
ERβ
G
protein‐coupled
ER
(GPER).
E2,
either
naturally
produced
or
exogenously
applied,
may
influence
excitability,
basal
synaptic
transmission
long‐term
potentiation.
These
effects
be
due
direct
action
signalling
pathways
dopamine
availability.
particular,
estradiol
influences
release,
receptor
expression
transporter
expression.
We
review
cellular
has
striatum,
distinguishing
between
applied
oestrous
cycle,
as
well
its
striatal‐dependent
behaviour.
Язык: Английский