Amygdala-derived-EEG-fMRI-pattern neurofeedback for the treatment of chronic post-traumatic stress disorder. A prospective, multicenter, multinational study evaluating clinical efficacy

Psychiatry Research, Год журнала: 2024, Номер 333, С. 115711 - 115711

Опубликована: Янв. 8, 2024

We conducted a prospective, single arm, multisite, multinational, open label trial assessing the safety and efficacy of novel amygdala derived neurofeedback treatment, designated Amygdala-Derived-EFP, for chronic PTSD. Participants, including veterans civilians, underwent screening, training, 15 sessions over 8 weeks and; baseline, termination (8 weeks) 3 month post treatment assessments with validated measures. The primary endpoint was more than 50% participants demonstrating Minimally Clinically Important Difference (MCID) defined as 6-point reduction, on Clinician Administered PTSD Scale (CAPS-5) total score at months. Secondary measures included PCL-5, ERQ, PHQ-9, CGI. Statistical analyses were performed using SAS®V9.4. met, CAPS-5 MCID response rate 66.7%. average reduction in scores follow up 13.5 points, twice MCID. Changes from baseline CAPS-5, PHQ-9 follow-up demonstrated statistically significant improvements effect sizes ranging 0.46 to 1.07. Adverse events mild resolved after treatment. This study builds prior research similar outcomes amygdala-derived neurofeedback. Positive attributes this therapy include monitoring by non-physician personnel, affordability, accessibility, tolerability.

Язык: Английский

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Amygdala downregulation training using fMRI neurofeedback in post-traumatic stress disorder: a randomized, double-blind trial

Translational Psychiatry, Год журнала: 2023, Номер 13(1)

Опубликована: Май 25, 2023

Abstract Hyperactivation of amygdala is a neural marker for post-traumatic stress disorder (PTSD) and improvement in control over activity has been associated with treatment success PTSD. In this randomized, double-blind clinical trial we evaluated the efficacy real-time fMRI neurofeedback intervention designed to train following trauma recall. Twenty-five patients PTSD completed three sessions training which they attempted downregulate feedback signal after exposure personalized scripts. For subjects active experimental group ( N = 14), was from functionally localized region their 11), yoked-sham provided. Changes symptoms served as primary secondary outcome measurements, respectively. We found significantly greater improvements than 30-days intervention. Both groups showed symptom scores, however reduction not group. Our finding suggests potential application treatment. Thus, further development treatment, including evaluation larger samples, warranted.

Язык: Английский

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Two is better? combining EEG and fMRI for BCI and neurofeedback: a systematic review

Journal of Neural Engineering, Год журнала: 2023, Номер 20(5), С. 051003 - 051003

Опубликована: Окт. 1, 2023

Abstract Electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) are two commonly used non-invasive techniques for measuring brain activity in neuroscience brain–computer interfaces (BCI). Objective . In this review, we focus on the use of EEG fMRI neurofeedback (NF) discuss challenges combining modalities to improve understanding achieve more effective clinical outcomes. Advanced technologies have been developed simultaneously record signals provide a better relationship between modalities. However, complexity processes heterogeneous nature present extracting useful information from combined data. Approach We will survey existing EEG–fMRI combinations recent studies that exploit NF, highlighting experimental technical challenges. Main results made classification different combination EEG-fMRI review multimodal analysis methods features. also current state research NF paradigms. Finally, identify some remaining field. Significance By exploring advancing our knowledge function its applications settings. As such, serves as valuable resource researchers, clinicians, engineers working field neural engineering rehabilitation, promising future EEG-fMRI-based NF.

Язык: Английский

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Amygdala self-neuromodulation capacity as a window for process-related network recruitment

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2024, Номер 379(1915)

Опубликована: Окт. 21, 2024

Neurofeedback (NF) has emerged as a promising avenue for demonstrating process-related neuroplasticity, enabling self-regulation of brain function. NF targeting the amygdala drawn attention to therapeutic potential in psychiatry, by potentially harnessing emotion-regulation processes. However, not all individuals respond equally training, possibly owing varying abilities. This underscores importance understanding mechanisms behind successful neuromodulation (i.e. capacity). study aimed investigate establishment and neural correlates capacity using data from repeated sessions electrical fingerprint (Amyg-EFP)-NF post-training functional magnetic resonance imaging (fMRI)-NF sessions. Results 97 participants (healthy controls post-traumatic stress disorder fibromyalgia patients) revealed increased Amyg-EFP over associated with amygdala-fMRI modulation improvements alexithymia. Individual differenaces this were pre-training reactivity initial success. Additionally, downregulation during fMRI-NF co-modulated other regions such posterior insula parahippocampal gyrus. combined better explained EFP-modulation improvement alexithymia than alone, suggesting relevance broader network gained capacity. These findings support network-based approach highlight need consider individual differences function optimize interventions. article is part theme issue ‘Neurofeedback: new territories neurocognitive endogenous neuromodulation’.

Язык: Английский

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Can Electroencephalography-Based Neurofeedback Treat Post-traumatic Stress Disorder? A Meta-analysis Study

Applied Psychophysiology and Biofeedback, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Язык: Английский

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Amygdala EFP Neurofeedback Effects on PTSD Symptom Clusters and Emotional Regulation Processes

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(7), С. 2421 - 2421

Опубликована: Апрель 2, 2025

Background: Post-traumatic stress disorder (PTSD) manifests through distinct symptom clusters that can respond differently to treatments. Neurofeedback guided by the Amygdala-derived-EEG-fMRI-Pattern (Amyg-EFP-NF) has been utilized train PTSD patients regulate amygdala-related activity and decrease symptoms. Methods: We conducted a combined analysis of 128 from three clinical trials Amyg-EFP-NF evaluate effects across (as assessed CAPS-5 subscales) on emotion regulation processing (evaluated ERQ). Results: significantly reduced severity all immediately post-treatment, with improvements maintained at three-month follow-up. The arousal reactivity cluster showed continued significant improvement during Combined effect sizes were large (η2p = 0.23-0.35) clusters. Regression revealed processes explained 17% variance in follow-up period. Conclusions: Reduction symptoms following occurs clusters, emotional potentially serving as an underlying mechanism action. These results support comprehensive treatment approach for continues show benefits after completion.

Язык: Английский

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Feasibility and utility of amygdala neurofeedback

Neuroscience & Biobehavioral Reviews, Год журнала: 2022, Номер 138, С. 104694 - 104694

Опубликована: Май 24, 2022

Язык: Английский

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Systematic review and meta-analysis of neurofeedback and its effect on posttraumatic stress disorder

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Март 21, 2024

Background To date, only one systematic review and meta-analysis of randomized controlled trials (RCTs) has evaluated the effect neurofeedback in PTSD, which included four studies found an uncertainty EEG-NF on PTSD symptoms. This is update considering that numerous have since been published. Additionally, more recent fMRI-NF as well fMRI-guided or -inspired EEG NF Methods Systematic literature searches for RCTs were conducted three online databases. Additional hand each study identified reviews meta-analyses published also undertaken. Outcomes vs. a control (active, sham, waiting list) their effects reducing symptoms using various health instruments. Meta-analytical methods used inverse variance random-effects models measuring both mean standardized differences. Quality certainty evidence assessed GRADE. Adverse events evaluated. Results A total 17 evaluating 628 patients. There 10 meta-analysis. from all favored neurofeedback’s including BDI pretest–posttest [mean difference (MD): 8.30 (95% CI: 3.09 to 13.52; P = 0.002; I 2 0%)]; pretest–follow-up (MD: 8.75 3.53 13.97; < 0.00001; 0%); CAPS-5 [MD: 7.01 1.36 12.66; 0.02; 86%)]; 1.29 21.29; 0.006; 77%); PCL-5 7.14 3.08 11.2; 0.0006; 14.95 7.95 21.96; 0.0001; 0%). Other reported improvements other GRADE assessments CAPS, PCL, demonstrated moderate/high level quality positive clinical effect. Conclusion Based newer outcomes measured, clinically meaningful size, with increased size at follow-up. appears be driven by deeper brain derivates it.

Язык: Английский

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Critically Assessing the Unanswered Questions of How, Where, and When to Induce Plasticity in the Posttraumatic Stress Disorder Network With Transcranial Magnetic Stimulation

Biological Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Июнь 1, 2024

Язык: Английский

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Neurorights in the Constitution: from neurotechnology to ethics and politics

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2024, Номер 379(1915)

Опубликована: Окт. 21, 2024

Neuroimaging technologies such as brain–computer interfaces and neurofeedback have evolved rapidly new tools for cognitive neuroscience potential clinical interventions. However, along with these developments, concern has grown based on the fear of misuse neurotechnology. In October 2021, Chile became first country to include neurorights in its Constitution. The present article is divided into two parts. section, we describe path followed by that led inclusion Chilean Constitution, neurotechnologies usually involved discussions. second part, discuss problems neurorights. We begin pointing out some epistemological concerns regarding neurorights, mainly referring ambiguity concepts used neurolegislations, difficult relationship between politics weak reasons urgency legislating. then dangers overprotective laws medical research, detrimental effect recent legislation risk posed benefits development. This aims engage scientific community interested neurotechnology an interdisciplinary reflection consequences part theme issue ‘Neurofeedback: territories neurocognitive mechanisms endogenous neuromodulation’.

Язык: Английский

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