Physical exercise-mediated neuroprotective mechanisms in Parkinson's disease, Alzheimer's disease, and epilepsy DOI Creative Commons
Ricardo A. Pinho, A. Müller, Luis Felipe Marqueze

и другие.

Brazilian Journal of Medical and Biological Research, Год журнала: 2024, Номер 57

Опубликована: Янв. 1, 2024

Research suggests that physical exercise is associated with prevention and management of chronic diseases. The influence on brain function metabolism the mechanisms involved are well documented in literature. This review provides a comprehensive overview potential implications molecular benefits Parkinson's disease, Alzheimer's epilepsy. Here, we present an effects various aspects function. To this end, conducted extensive literature search PubMed, Web Science, Google Scholar databases to identify articles published past two decades. delves into key including modulation neuroinflammation, neurotrophic factors, synaptic plasticity. Moreover, explored role advancing therapeutic strategies for these In conclusion, highlights importance regular as complementary non-pharmacological treatment individuals neurological disorders such Alzheimer's,

Язык: Английский

The Effect of Multimodal Exercise on the Levels of BDNF and GDNF in Patients with Parkinson’s Disease DOI Creative Commons

Abbas Abdulameer Naser,

Khosro Jalali Dehkordi,

Mahmoud Nasser Radhi

и другие.

International Journal of Preventive Medicine, Год журнала: 2025, Номер 16

Опубликована: Май 1, 2025

Abstract Background: Parkinson’s disease (PD) leads to a significant decrease in brain-derived neurotrophic factor (BDNF) and glial cell line-derived (GDNF). This study explores the effect of 12 weeks multimodal exercise on levels BDNF GDNF patients with PD. Methods: The is quasiexperimental random sampling. It was conducted 2024 at Isfahan. Demographic data were collected using demographic questionnaire outlined Methods section. Thirty randomly divided into two equal groups control, no differences age, weight, height. variables assessed pre- post-tests. Multimodal performed 5 days week for weeks. Data analyzed covariance t -test level P < 0.05. Results: observed GDNF, among PD ( 0.01). Moreover, significantly higher + Training group compared 0. 01). Conclusions: Given that exercises are effective increasing individuals PD, it recommended incorporate benefits these physical rehabilitation programs. Therefore, combined approach (resistance, aerobic, balance) as most complementary therapeutic strategy

Язык: Английский

Процитировано

0

Combination Therapy of Estrogen and Progesterone Attenuates Behavioral Impairments and Autophagy via circLrp1b/miR-27a-3p/Dram2 Pathway After Traumatic Brain Injury DOI
Ladan Amirkhosravi, Mohammad Khaksari, Mohammad Amin Rajizadeh

и другие.

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

Язык: Английский

Процитировано

0

A comprehensive and updated review on the applications of vesicular drug delivery systems in treatment of brain disorders: A shelter against storms DOI Open Access
Mohammad Amin Rajizadeh, Sina Motamedy, Yousof Mir

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 89, С. 105011 - 105011

Опубликована: Окт. 5, 2023

Язык: Английский

Процитировано

7

Myrtenol Inhalation Mitigates Asthma-Induced Cognitive Impairments: an Electrophysiological, Behavioral, Histological, and Molecular Study DOI
Khadijeh Esmaeilpour, Elham Jafari, Fahimeh Rostamabadi

и другие.

Molecular Neurobiology, Год журнала: 2023, Номер 61(7), С. 4891 - 4907

Опубликована: Дек. 27, 2023

Язык: Английский

Процитировано

7

The effect of high-intensity interval training on type 2 diabetic muscle: A metabolomics-based study DOI Creative Commons
Kayvan Khoramipour, Mohammad Amin Rajizadeh, Ziba Akbari

и другие.

Heliyon, Год журнала: 2024, Номер 10(15), С. e34917 - e34917

Опубликована: Июль 20, 2024

BackgroundThis study aimed to investigate the effect of eight weeks high-intensity interval training (HIIT) on muscle metabolism in rats with type 2 diabetes (T2D) using metabolomics approaches.Methods20 male Wistar at age 8 weeks-were assigned four groups five, each group randomly: control (CTL), (DB), HIIT (EX), and + (DBX). T2D was induced by two months a high-fat diet plus single dose streptozotocin (35 mg/kg). Rats EX DBX performed (running 80–100 % Vmax, 4–10 intervals). NMR spectroscopy used determine changes metabolome profile after training.ResultsChanges metabolite abundance following exercise revealed distinct clustering multivariate analysis. The essential between DB CTL were arginine metabolism, purine phosphate pathway, amino sugar glutathione aminoacyl-tRNA biosynthesis. However, Arginine biosynthesis, pyrimidine alanine, aspartate, glutamate altered groups.ConclusionThese results suggest that could reverse metabolic rat muscles, contributing reduced FBG HOMA-IR levels.

Язык: Английский

Процитировано

2

Exercise and exerkine upregulation: Brain-derived neurotrophic factor as a potential non-pharmacological therapeutic strategy for Parkinson’s disease DOI Open Access

VIRAAJ VISHNU PRASAD,

Jennifer Sally Samson,

Venkatachalam Deepa Parvathi

и другие.

Biocell, Год журнала: 2024, Номер 48(5), С. 693 - 706

Опубликована: Янв. 1, 2024

Physical activity and exercise have several beneficial roles in enhancing both physiological psychological well-being of an individual.In addition to aiding the regulation aerobic anaerobic metabolism, can stimulate synthesis exerkine hormones circulatory system.Among exerkines that been investigated for their therapeutic potential, Brain-derived neurotrophic factor (BDNF) is considered most promising candidate, especially management neurodegenerative diseases.Owing ability physical enhance BDNF synthesis, experimental studies conducted so far validated this hypothesis produced satisfactory results at pre-clinical level.This review highlights some recent animal model evaluated efficiency promoting neuroprotective effects.Further, focuses on understanding benefits exercise-induced as a non-pharmacological strategy Parkinson's disease (PD).Regarding induction, neuromuscular electrical stimulation (NMES) could be alternate treatment modality patients affected with PD.

Язык: Английский

Процитировано

1

Physical exercise-mediated neuroprotective mechanisms in Parkinson's disease, Alzheimer's disease, and epilepsy DOI Creative Commons
Ricardo A. Pinho, A. Müller, Luis Felipe Marqueze

и другие.

Brazilian Journal of Medical and Biological Research, Год журнала: 2024, Номер 57

Опубликована: Янв. 1, 2024

Research suggests that physical exercise is associated with prevention and management of chronic diseases. The influence on brain function metabolism the mechanisms involved are well documented in literature. This review provides a comprehensive overview potential implications molecular benefits Parkinson's disease, Alzheimer's epilepsy. Here, we present an effects various aspects function. To this end, conducted extensive literature search PubMed, Web Science, Google Scholar databases to identify articles published past two decades. delves into key including modulation neuroinflammation, neurotrophic factors, synaptic plasticity. Moreover, explored role advancing therapeutic strategies for these In conclusion, highlights importance regular as complementary non-pharmacological treatment individuals neurological disorders such Alzheimer's,

Язык: Английский

Процитировано

1