Brazilian Journal of Medical and Biological Research,
Год журнала:
2024,
Номер
57
Опубликована: Янв. 1, 2024
Research
suggests
that
physical
exercise
is
associated
with
prevention
and
management
of
chronic
diseases.
The
influence
on
brain
function
metabolism
the
mechanisms
involved
are
well
documented
in
literature.
This
review
provides
a
comprehensive
overview
potential
implications
molecular
benefits
Parkinson's
disease,
Alzheimer's
epilepsy.
Here,
we
present
an
effects
various
aspects
function.
To
this
end,
conducted
extensive
literature
search
PubMed,
Web
Science,
Google
Scholar
databases
to
identify
articles
published
past
two
decades.
delves
into
key
including
modulation
neuroinflammation,
neurotrophic
factors,
synaptic
plasticity.
Moreover,
explored
role
advancing
therapeutic
strategies
for
these
In
conclusion,
highlights
importance
regular
as
complementary
non-pharmacological
treatment
individuals
neurological
disorders
such
Alzheimer's,
International Journal of Preventive Medicine,
Год журнала:
2025,
Номер
16
Опубликована: Май 1, 2025
Abstract
Background:
Parkinson’s
disease
(PD)
leads
to
a
significant
decrease
in
brain-derived
neurotrophic
factor
(BDNF)
and
glial
cell
line-derived
(GDNF).
This
study
explores
the
effect
of
12
weeks
multimodal
exercise
on
levels
BDNF
GDNF
patients
with
PD.
Methods:
The
is
quasiexperimental
random
sampling.
It
was
conducted
2024
at
Isfahan.
Demographic
data
were
collected
using
demographic
questionnaire
outlined
Methods
section.
Thirty
randomly
divided
into
two
equal
groups
control,
no
differences
age,
weight,
height.
variables
assessed
pre-
post-tests.
Multimodal
performed
5
days
week
for
weeks.
Data
analyzed
covariance
t
-test
level
P
<
0.05.
Results:
observed
GDNF,
among
PD
(
0.01).
Moreover,
significantly
higher
+
Training
group
compared
0.
01).
Conclusions:
Given
that
exercises
are
effective
increasing
individuals
PD,
it
recommended
incorporate
benefits
these
physical
rehabilitation
programs.
Therefore,
combined
approach
(resistance,
aerobic,
balance)
as
most
complementary
therapeutic
strategy
Heliyon,
Год журнала:
2024,
Номер
10(15), С. e34917 - e34917
Опубликована: Июль 20, 2024
BackgroundThis
study
aimed
to
investigate
the
effect
of
eight
weeks
high-intensity
interval
training
(HIIT)
on
muscle
metabolism
in
rats
with
type
2
diabetes
(T2D)
using
metabolomics
approaches.Methods20
male
Wistar
at
age
8
weeks-were
assigned
four
groups
five,
each
group
randomly:
control
(CTL),
(DB),
HIIT
(EX),
and
+
(DBX).
T2D
was
induced
by
two
months
a
high-fat
diet
plus
single
dose
streptozotocin
(35
mg/kg).
Rats
EX
DBX
performed
(running
80–100
%
Vmax,
4–10
intervals).
NMR
spectroscopy
used
determine
changes
metabolome
profile
after
training.ResultsChanges
metabolite
abundance
following
exercise
revealed
distinct
clustering
multivariate
analysis.
The
essential
between
DB
CTL
were
arginine
metabolism,
purine
phosphate
pathway,
amino
sugar
glutathione
aminoacyl-tRNA
biosynthesis.
However,
Arginine
biosynthesis,
pyrimidine
alanine,
aspartate,
glutamate
altered
groups.ConclusionThese
results
suggest
that
could
reverse
metabolic
rat
muscles,
contributing
reduced
FBG
HOMA-IR
levels.
Biocell,
Год журнала:
2024,
Номер
48(5), С. 693 - 706
Опубликована: Янв. 1, 2024
Physical
activity
and
exercise
have
several
beneficial
roles
in
enhancing
both
physiological
psychological
well-being
of
an
individual.In
addition
to
aiding
the
regulation
aerobic
anaerobic
metabolism,
can
stimulate
synthesis
exerkine
hormones
circulatory
system.Among
exerkines
that
been
investigated
for
their
therapeutic
potential,
Brain-derived
neurotrophic
factor
(BDNF)
is
considered
most
promising
candidate,
especially
management
neurodegenerative
diseases.Owing
ability
physical
enhance
BDNF
synthesis,
experimental
studies
conducted
so
far
validated
this
hypothesis
produced
satisfactory
results
at
pre-clinical
level.This
review
highlights
some
recent
animal
model
evaluated
efficiency
promoting
neuroprotective
effects.Further,
focuses
on
understanding
benefits
exercise-induced
as
a
non-pharmacological
strategy
Parkinson's
disease
(PD).Regarding
induction,
neuromuscular
electrical
stimulation
(NMES)
could
be
alternate
treatment
modality
patients
affected
with
PD.
Brazilian Journal of Medical and Biological Research,
Год журнала:
2024,
Номер
57
Опубликована: Янв. 1, 2024
Research
suggests
that
physical
exercise
is
associated
with
prevention
and
management
of
chronic
diseases.
The
influence
on
brain
function
metabolism
the
mechanisms
involved
are
well
documented
in
literature.
This
review
provides
a
comprehensive
overview
potential
implications
molecular
benefits
Parkinson's
disease,
Alzheimer's
epilepsy.
Here,
we
present
an
effects
various
aspects
function.
To
this
end,
conducted
extensive
literature
search
PubMed,
Web
Science,
Google
Scholar
databases
to
identify
articles
published
past
two
decades.
delves
into
key
including
modulation
neuroinflammation,
neurotrophic
factors,
synaptic
plasticity.
Moreover,
explored
role
advancing
therapeutic
strategies
for
these
In
conclusion,
highlights
importance
regular
as
complementary
non-pharmacological
treatment
individuals
neurological
disorders
such
Alzheimer's,
