Vrach,
Год журнала:
2024,
Номер
unknown, С. 14 - 17
Опубликована: Ноя. 19, 2024
Treatment
of
bone
pathologies
and
severe
fractures
is
an
urgent
healthcare
problem
that
requires
effective
innovative
approaches
to
ensure
complete
restoration
tissue
improve
the
quality
life
patients.
Traditional
methods
regeneration,
such
as
transplantation
autografts
allografts,
have
a
number
limitations,
including
shortage
donor
material
risk
complications.
In
this
regard,
it
interest
use
osteoinductive
materials
promote
accelerated
healing
structures.
The
article
discusses
modern
materials,
their
types,
mechanisms
action
clinical
application.
Particular
attention
paid
role
in
treatment
complex
pathologies,
osteoporosis
osteomyelitis.
Data
from
studies
been
analyzed
demonstrating
high
effectiveness
fractures,
osteomyelitis,
osteonecrosis
other
pathologies.
Benefits
using
these
include
healing,
reduced
complications,
minimized
need
for
autografts,
improved
integration
with
tissue.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Abstract
The
distinctive
structure
and
composition
of
the
Haversian
canal
within
osteons
play
a
pivotal
role
in
sustaining
nutritional
supply
to
individual
bone
cells.
Consequently,
osteon's
inherent
advantages
facilitating
repair
have
garnered
increasing
attention.
However,
most
existing
designs
emulate
only
partial
aspects
architecture,
failing
replicate
its
functionality
comprehensively.
This
study
aimed
develop
functional
3D
biomimetic
osteon
enhance
regeneration.
To
achieve
this,
oriented
nanofibers
mimicking
osteonal
lamellae
are
fabricated
via
electrospinning,
while
blood
vessel,
simulating
canal,
is
constructed
using
microfluidics
technology.
vessels,
seeded
with
rat
umbilical
vein
endothelial
cells,
secreted
morphogenetic
protein
stimulate
osteogenesis
released
platelet‐derived
growth
factor
promote
angiogenesis,
further
supporting
processes.
nanofibers,
composed
type
I
collagen
nano‐hydroxyapatite,
calcium
ions,
can
facilitate
recruitment
marrow
mesenchymal
stem
their
adhesion
fibers,
osteogenic
differentiation.
These
findings
demonstrate
that
replicating
both
natural
function
tissue
provides
superior
strategy
for
repair.
The
massive
accumulation
of
exudate
containing
high
concentrations
glucose
causes
wound
infection
and
triggers
the
release
inflammatory
factors,
which
in
turn
delays
closure
diabetic
wounds.
In
this
study,
a
Janus
membrane
is
constructed
by
combining
oxidase
(GOx)
copper
ions
(Cu
Biodegradable
scaffolds,
including
metals,
ceramics,
and
polymers,
show
great
potential
in
bone
tissue
regeneration.
However,
current
biodegradable
scaffolds
do
not
simultaneously
possess
suitable
mechanical
properties,
biodegradability
osteoinductivity,
which
severely
limits
their
clinical
application
for
large
segmental
defect
repair.
Herein,
we
developed
a
biomimetic
hierarchically
micro-nanoporous
iron-based
scaffold
utilizing
synergistic
approach
combining
3-dimensional
printing,
surface
dealloying
treatment
electrochemical
deposition.
Compared
to
traditional
periodic
lattice
structures,
the
with
stochastic
structure
promised
superior
stress
transfer
efficiency.
Cell
experiments
revealed
that
notably
enhanced
osteogenesis
angiogenesis
vitro
via
EGFR-mediated
Ras/Raf/MAPK
signaling.
Upon
implantation
rat
femoral
condyle
model,
achieved
dynamic
equilibrium
between
vivo
material
degradation
formation.
More
importantly,
study
conducted
animal
model
an
extended
cycle
of
up
1
year
demonstrated
bionic
effectively
facilitated
repair
functional
reconstruction
defects
load-bearing
regions
by
inducing
vascularized
This
only
introduces
solution
addressing
critical-sized
but
also
provides
viable
design
other
biomaterials.
Acta Biomaterialia,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Large
bone
defects,
often
arising
from
trauma
or
infection,
pose
a
considerable
therapeutic
challenge
due
to
their
limited
capacity
for
spontaneous
healing,
thus
requiring
graft
materials
effective
reparative
procedures.
The
persistence
of
inflammation
and
elevated
levels
reactive
oxygen
species
(ROS)
within
these
defect
sites
significantly
impede
regeneration
process.
Addressing
this,
an
injectable
hydrogel
system
with
ROS-responsive
functionality
is
developed,
specifically
tailored
the
high
ROS
microenvironment
characteristic
defects.
This
incorporates
hyaluronic
acid
functionalized
dopamine
introduce
catechol
moieties,
employs
4-formylphenylboronic
as
crosslinking
agent
form
dynamic
matrix
(HAC)
carboxymethyl
chitosan.
HAC
serves
carrier
dimethyl
fumarate
(DMF),
compound
established
anti-inflammatory
antioxidant
effects,
enabling
its
controlled
release
in
response
levels.
Herein,
we
investigated
physicochemical
properties
DMF
loaded
(DHAC)
by
microstructure
observation,
vitro
degradation
assay,
self-healing
test,
injectability
experiments,
drug
assay.
Meanwhile,
systematically
effects
on
inflammation,
intracellular
ROS,
osteogenesis.
Consequently,
DHAC
reduced
pro-inflammatory
cytokines
secreted
RAW264.7
cells
scavenged
MC3T3
cells.
effect
was
accompanied
augmentation
osteogenic
potential
promotion
repair
cranial
defects
rats.
DHAC,
which
exhibits
anti-inflammatory,
antioxidant,
activity,
hold
great
strategy
management
large
STATEMENT
OF
SIGNIFICANCE:
Here,
novel
fumarate-loaded
developed
treatment
Our
findings
demonstrated
that
not
only
promotes
but
also
controls
addressing
two
critical
challenges
healing.
Comprehensive
evaluations
show
significant
improvements
formation
reduction
animal
models.
Additionally,
excellent
scavenging
ability,
effectively
modulating
oxidative
stress
microenvironment.
Findings
suggest
may
serve
promising
clinical
critical-sized
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Tissue
engineering
aims
to
repair
damaged
tissues
with
physiological
functions
recovery.
Although
several
therapeutic
strategies
are
there
for
tissue
regeneration,
the
functional
recovery
of
regenerated
still
poses
significant
challenges
due
lack
concerns
innervation.
Design
rationale
multifunctional
biomaterials
both
tissue-induction
and
neural
induction
activities
shows
great
potential
regeneration.
Recently,
research
application
inorganic
attracts
increasing
attention
in
innervated
multi-tissue
such
as
central
nerves,
bone,
skin,
because
its
superior
tunable
chemical
composition,
topographical
structures,
physiochemical
properties.
More
importantly,
easily
combined
other
organic
materials,
biological
factors,
external
stimuli
enhance
their
effects.
This
review
presents
a
comprehensive
overview
recent
advancements
It
begins
introducing
classification
properties
typical
design
inorganic-based
material
composites.
Then,
progresses
regenerating
various
nerves
nerve-innervated
systematically
reviewed.
Finally,
existing
future
perspectives
proposed.
may
pave
way
direction
offers
new
strategy
regeneration
combination
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 28, 2025
Abstract
Calcium
phosphates
(CaPs)
are
ubiquitous
in
biological
structures,
such
as
vertebrate
bones
and
teeth,
have
been
widely
used
biomedical
applications.
However,
fabricating
CaPs
at
the
nanoscale
3D
has
remained
a
significant
challenge,
particularly
due
to
limitations
current
nanofabrication
techniques,
two‐photon
polymerization
(2pp),
which
not
applicable
for
creating
CaP
nanostructures.
In
this
study,
novel
approach
is
presented
print
structures
with
unprecedented
resolution
of
≈300
nm
precision,
achieving
level
detail
three
orders
magnitude
finer
than
any
existing
additive
manufacturing
techniques
CaPs.
This
advancement
achieved
by
leveraging
bioinspired
chemistry,
utilizing
bone
prenucleation
nanoclusters
(PNCs,
average
size
5
nm),
within
photosensitive
resin.
These
form
highly
transparent
photoresist,
overcoming
light‐scattering
typically
associated
larger
calcium
phosphate‐based
nanoparticles.
method
only
allows
nanopatterning
on
diverse
substrates,
but
also
enables
precise
control
microstructure
down
submicron
grains.
The
paves
way
developing
metamaterials,
lightweight
damage‐tolerant
materials,
cell‐modulating
interfaces,
precision‐engineered
coatings.
