Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Апрель 8, 2024

The incidence of inflammatory bowel disease (IBD) and the associated risk colon cancer are increasing globally. Traditional Chinese medicine (TCM) treatment has unique advantages. Sishen Pill, a common patented drug used to treat abdominal pain diarrhea, consists mainly Psoraleae Fructus, Myristicae Semen, Euodiae Schisandra Chinensis. Modern research confirmed that Pill its active secondary metabolites, such as psoralen, myristicin, evodiamine, schisandrin, can improve intestinal inflammation exert antitumor pharmacological effects. Common mechanisms in treating IBD include regulating inflammation-related signaling pathways nuclear factor-kappa B, mitogen-activated protein kinase, phosphatidylinositol 3-kinase, NOD-like receptor heat domain-related 3, wingless-type MMTV integration site family; NF-E2-related factor 2 hypoxia-inducible 1α inhibit oxidative stress; mitochondrial autophagy endoplasmic reticulum immune cell differentiation function through Janus kinase/signal transducer activator transcription pathway; improving gut microbiota barrier. Overall, existing evidence suggests potential pill suppress inflammation-to-cancer transformation. However, large-scale randomized controlled clinical studies on safety these applications urgently required.

Язык: Английский

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The preventive and therapeutic effects of anthocyanins on colorectal cancer: A comprehensive review based on up-to-date experimental studies

Food Research International, Год журнала: 2023, Номер 170, С. 113028 - 113028

Опубликована: Май 24, 2023

Язык: Английский

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Jacalin Attenuates Colitis-Associated Colorectal Carcinogenesis by Inhibiting Tumor Cell Proliferation and Intestinal Inflammation

Inflammatory Bowel Diseases, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Abstract Background Colorectal cancer (CRC) remains a significant cause of morbidity and mortality worldwide. In patients with inflammatory bowel disease, who have twice the risk developing CRC, chronic inflammation has been recognized to contribute colitis-associated (CAC) development. Jacalin, lectin extracted from jackfruit seeds, shown recognize altered glycosylation exert antiproliferative cytotoxic effects in CRC. However, its activity CAC unknown. Herein, we sought investigate jacalin progression using dextran sulfate sodium (DSS) azoxymethane (AOM) mouse model. Methods Colitis-associated induction was performed male C57BL/6 mice by an intraperitoneal injection AOM, followed 3 cycles 2.5% DSS diluted drinking water for 7 days, intercalated 2 weeks normal water. After 1 week daily pretreatment, were orally treated phosphate-buffered saline (control group), 100 or 500 µg three times additional 11 weeks. Results We showed that jacalin-treated presented tumors reduced volumes mean size compared control group. addition, both doses number proliferating cells (Ki-67 positive cells) tumor tissues, while higher dose (500 µg) also similar effect “normal-appearing” colonic crypts. Jacalin treatment attenuated clinical scores inflammations, which accompanied reduction intestinal and/or tumoral production IL-1β, IL-23, IL-17. Conclusions Collectively, our findings demonstrated suppresses development, highlighting anti-inflammatory antitumoral role AOM/DSS-induced

Язык: Английский

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Inflammatory mechanisms in colorectal cancer: The role of cytokines and dietary inflammatory index : A review

SANAMED, Год журнала: 2025, Номер 00, С. 76 - 76

Опубликована: Янв. 1, 2025

Colorectal cancer is one of the most common malignant tumors, with numerous studies highlighting role inflammation in its onset and progression. Cytokines such as IL-6 TNF-a play a crucial sustaining inflammation, contributing to transformation cells. The dietary inflammatory index, which reflects intake pro-inflammatory nutrients, associated an increased risk developing colorectal cancer. Serum cytokine concentrations may serve biomarkers for assessment, while modifications aimed at reducing can significantly impact both prevention therapy. This knowledge opens possibilities personalized approach treatment

Язык: Английский

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NSD3: A Promising Target for Cancer Therapy

Cell Biochemistry and Function, Год журнала: 2025, Номер 43(4)

Опубликована: Март 26, 2025

Over the past 24 years, nuclear receptor-binding SET domain protein 3 (NSD3) has emerged as a critical regulator of cellular physiological processes. As histone methyltransferase targeting H3K36, NSD3 catalyzes addition methyl groups to residues, process that profoundly influences genome imprinting, gene transcription, and stability, thereby modulating expression. Amplification, mutations, fusion events involving have been strongly linked pathogenesis various cancers, highlighting its role key tumorigenesis. This review provides an overview general structure biological functions NSD3, followed by analysis NSD3's in relation hallmarks cancer described Hanahan Weinberg. Targeting become major focus research, with significant efforts directed toward development clinical application inhibitors. However, challenges related specificity selectivity hindered progress this area. Despite these obstacles, successful advancement other inhibitors provided encouragement researchers, driving active pursuit NSD3-targeted therapies for treatment.

Язык: Английский

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The power of microbes: the key role of gut microbiota in the initiation and progression of colorectal cancer

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Апрель 14, 2025

Colorectal cancer (CRC) is ranked as the third most prevalent malignancy and a leading cause of cancer-related mortality globally, significantly affecting health longevity middle-aged individuals elderly. The primary risk factors for CRC are mainly due to unhealthy dietary habits lifestyle choices, they have been shown profoundly influence composition gut microbiota. Given that patterns critical determinants microbial diversity, compelling association exists between microbiota pathogenesis CRC. Recent research has increasingly focused on intricate interplay CRC, exploring its role in disease initiation, progression, modulation host immune responses. Investigations demonstrated certain specific communities can promote inflammation, disrupt metabolic pathways, produce carcinogenic compounds, thereby contributing development Conversely, diverse balanced microbiome may confer protective effects against through mechanisms such production short-chain fatty acids enhancement intestinal barrier integrity. This article provides comprehensive overview characteristics community complex relationship with It highlights potential which pathogenesis, including chronic toxins, metabolites, epigenetic dysregulation, regulatory dysfunction. Additionally, this review summarizes innovative strategies prevention treatment, emphasizing therapeutic probiotics natural plant extracts. By elucidating these connections, work aims enhance understanding microbiome’s

Язык: Английский

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Exploring the interconnected pathobiology between Crohn's disease, ulcerative colitis and colorectal cancer through gene expression, pathway analysis and immune profiling

Human Gene, Год журнала: 2025, Номер unknown, С. 201404 - 201404

Опубликована: Апрель 1, 2025

Язык: Английский

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Interventional effect of hesperetin on N-methyl-N’-nitro-N-nitrosoguanidine-induced exosomal circ008274 in affecting normal cells to promote gastric carcinogenesis

World Journal of Gastroenterology, Год журнала: 2025, Номер 31(16)

Опубликована: Апрель 25, 2025

Hesperetin, a flavonoid predominantly present in citrus fruits, exhibits significant intervention effects on both the initiation and progression of gastric cancer. However, specific mechanisms underlying this effect remain unclear. To investigate interventional role hesperetin N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced exosomes inducing carcinogenesis. Bioinformatics technology was used to identify critical molecular components hesperetin-mediated inhibition MNNG induced carcinogenesis through exosomal circular RNA. Biological experiments were conducted validate these findings. Exosomes derived from TGES-1 cells (TGES-1-EX) significantly enhanced proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), stemness GES-1 cells. The oncogenic potential TGES-1-EX diminished following pretreatment. with overexpressed or knocked down circ0008274 extracted treated combination alone. Our investigation revealed that exerted inhibitory MNNG-induced by circ0008274. prediction identified microRNA (miR)-526b-5p as miRNA binding Functional demonstrated may mediate its cancer targeting miR-526b-5p promoted EMT, stem cell-like characteristics miR-526b-5p-mediated regulatory mechanisms. Hesperetin an process, particularly modulation interaction miR-526b-5p.

Язык: Английский

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Development of trans-Chalcone loaded pectin/casein biodegradable microcapsules: Efficacy improvement in the management of experimental colitis

International Journal of Pharmaceutics, Год журнала: 2023, Номер 642, С. 123206 - 123206

Опубликована: Июль 1, 2023

Язык: Английский

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Tumorigenesis in Inflammatory Bowel Disease: Microbiota-Environment Interconnections

Cancers, Год журнала: 2023, Номер 15(12), С. 3200 - 3200

Опубликована: Июнь 15, 2023

Colo-rectal cancer (CRC) is undoubtedly one of the most severe complications inflammatory bowel diseases (IBD). While sporadic CRC develops from a typical adenoma-carcinoma sequence, IBD-related follows different and less understood pathways its pathophysiological mechanisms were not completely elucidated. In contrast to chronic inflammation, which nowadays well-recognised drive towards neoplastic transformation in IBD, only recently was gut microbiota demonstrated interfere with both inflammation processes immune-mediated anticancer surveillance. Moreover, role appears particularly complex intriguing when also considering multifaceted interactions multiple environmental stimuli, notably pathologies such as diabetes obesity, lifestyle (diet, smoking) vitamin intake. this review, we presented comprehensive overview on current evidence influence CRC, particular mutual interconnections environment.

Язык: Английский

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