Confrontation of the ambivalent roles of the intestinal microbiota in carcinogenesis: Oncogenic or anticancer agents?

Journal Of Advanced Pharmacy Education And Research, Год журнала: 2025, Номер 15(2), С. 16 - 30

Опубликована: Янв. 1, 2025

Язык: Английский

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Photobiomodulation and the oral-gut microbiome axis: therapeutic potential and challenges

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Апрель 9, 2025

This Perspective article explores the challenges associated with direct application of photobiomodulation (PBM) to gut and presents a novel hypothesis for indirect health modulation through oral microbiome alteration. Given difficulties in delivering PBM effectively deep gastrointestinal tissues, an alternative approach involves targeting microbiome, which has demonstrated relationship microbiome. Research indicates that applied cavity could selectively alter microbial composition. alteration may, via oral-gut axis, indirectly impact health. hypothesis, supported by preliminary studies, suggests offer promising non-invasive strategy managing gut-related disorders. Furthermore, there may be link between brain diseases. proximity brain, PBM-induced changes microbiota help prevent neurological However, further investigation is necessary comprehensively elucidate underlying mechanisms therapeutic implications this approach.

Язык: Английский

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Microsporidian infection of mosquito larvae changes the host-associated microbiome towards the synthesis of antimicrobial factors

Parasites & Vectors, Год журнала: 2025, Номер 18(1)

Опубликована: Май 17, 2025

Язык: Английский

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The Bidirectional Relationship Between Cardiovascular Medications and Oral and Gut Microbiome Health: A Comprehensive Review

Microorganisms, Год журнала: 2024, Номер 12(11), С. 2246 - 2246

Опубликована: Ноя. 6, 2024

Cardiovascular diseases (CVDs) are a leading cause of widespread morbidity and mortality. It has been found that the gut oral microbiomes differ in individuals with CVDs compared to healthy individuals. Patients often require long-term pharmacological interventions. While these medications have extensively studied for their cardiovascular benefits, emerging research indicates they may also impact diversity composition microbiomes. However, our understanding how factors influence compositions remains limited. Studies shown statins beta-blockers, particular, microbial dysbiosis, impacting metabolism absorption medications. These alterations can lead variations drug responses, highlighting need personalized treatment approaches. The microbiome's role CVD on microbiome crucial variations. there very few studies this area, not all studied, emphasizing necessity further conclusively establish cause-and-effect relationships determine clinical significance interactions. This review will provide evidence patients interact specific drugs used treatment.

Язык: Английский

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Assessing the Interactions between Zinc and Vitamin A on Intestinal Functionality, Morphology, and the Microbiome In Vivo (Gallus gallus)

Nutrients, Год журнала: 2023, Номер 15(12), С. 2754 - 2754

Опубликована: Июнь 15, 2023

Dietary deficiencies in zinc (Zn) and vitamin A (VA) are among the leading micronutrient globally previous research has proposed a notable interaction between Zn VA physiological status. This study aimed to assess effects of (isolated combined) on intestinal functionality morphology, gut microbiome (Gallus gallus). The included nine treatment groups (n~11)-no-injection (NI); H2O; 0.5% oil; normal (40 mg/kg ZnSO4) (ZN); low (20 mg/kg) (ZL); retinoid (1500 IU/kg retinyl palmitate) (RN); (100 IU/kg) (RL); mg/kg; 1500 (ZNRN); (ZLRL) 100 IU/kg). Samples were injected into amniotic fluid fertile broiler eggs. Tissue samples collected upon hatch target biomarkers. ZLRL reduced ZIP4 gene expression upregulated ZnT1 (p < 0.05). Duodenal surface area increased greatest RL compared RN 0.01), ZNRN All nutrient treatments yielded shorter crypt depths 0.01). Compared oil control, 0.05) cecal abundance Bifidobacterium Clostridium genera These results suggest potentially improved epithelium proceeding with intra-amniotic administration. Intestinal bacteria modulated. Further should characterize long-term responses profile.

Язык: Английский

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When inflammatory stressors dramatically change, disease phenotypes may transform between autoimmune hematopoietic failure and myeloid neoplasms

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Фев. 15, 2024

Aplastic anemia (AA) and hypoplastic myelodysplastic syndrome are paradigms of autoimmune hematopoietic failure (AHF). Myelodysplastic acute myeloid leukemia unequivocal neoplasms (MNs). Currently, AA is also known to be a clonal hematological disease. Genetic aberrations typically observed in MNs detected approximately one-third patients. In patients harboring MN-related genetic aberrations, poor response immunosuppressive therapy (IST) an increased risk transformation occurring either naturally or after IST predicted. Approximately 10%-15% with severe transform the disease phenotype following IST, some patients, leukemic emerges during shortly IST. Phenotypic transformations between AHF can occur reciprocally. A fraction advanced MN experience aplastic crisis which blasts repressed. The switch that shapes change strength extramedullary inflammation. Both have immune-active bone marrow (BM) environment (BME). inflamed BME evoked by infiltrated immune cells targeting neoplastic molecules, contributes BM-specific impairment. Autoimmune responses may represent antileukemic mechanism, inflammatory stressors strengthen immunity, at least significant proportion who aberrations. During active episodes, normal hematopoieses suppressed, leads occurrence cytopenia cell regression. successful treatment underlying infections mitigates stress-related activities promotes penetration hematopoiesis. effect similar treating infections. Investigating stress-powered immunity highly important theoretical studies clinical practice, especially given wide application immune-activating agents checkpoint inhibitors neoplasms.

Язык: Английский

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Neuroimaging techniques, gene therapy, and gut microbiota: frontier advances and integrated applications in Alzheimer’s Disease research

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Дек. 3, 2024

Alzheimer’s Disease (AD) is a neurodegenerative disorder marked by cognitive decline, for which effective treatments remain elusive due to complex pathogenesis. Recent advances in neuroimaging, gene therapy, and gut microbiota research offer new insights potential intervention strategies. Neuroimaging enables early detection staging of AD through visualization biomarkers, aiding diagnosis tracking disease progression. Gene therapy presents promising approach modifying AD-related genetic expressions, targeting amyloid tau pathology, potentially repairing neuronal damage. Furthermore, emerging evidence suggests that the influences pathology gut-brain axis, impacting inflammation, immune response, metabolism. However, each these technologies faces significant challenges, including concerns about safety, efficacy, ethical considerations. This article reviews applications, advantages, limitations AD, with particular focus on their combined diagnosis, mechanistic insights, therapeutic interventions. We propose an integrated leverages tools provide multi-dimensional framework advancing treatment, prevention.

Язык: Английский

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Translating microbiota analysis for clinical applications

Nature Reviews Bioengineering, Год журнала: 2024, Номер 2(4), С. 284 - 286

Опубликована: Фев. 28, 2024

Язык: Английский

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Culturing the unculturables: strategies, challenges, and opportunities for gut microbiome study

Journal of Applied Microbiology, Год журнала: 2023, Номер 134(12)

Опубликована: Ноя. 24, 2023

Abstract Metagenome sequencing techniques revolutionized the field of gut microbiome study. However, it is equipped with experimental and computational biases, which affect downstream analysis results. Also, live microbial strains are needed for a better understanding host-microbial crosstalks designing next-generation treatment therapies based on probiotic postbiotic molecules. Conventional culturing methodologies insufficient to get dark matter plate; therefore, there an urgent need propose novel methods that can fill limitations metagenomics. The current work aims provide consolidated evaluation available host-microbe interaction emphasis in vitro microbes using organoids, chip, bioreactor. Further, knowledge crosstalk helps us identify core microbiota, key metabolites will aid media co-culturing systems After deeper mining methods, we recommend 3D-printed intestinal cells multistage continuous flow reactor extended organoid system might be good practical choice microbiota-based studies.

Язык: Английский

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Regulación del microbioma intestinal y su impacto en la obesidad

MQRInvestigar, Год журнала: 2024, Номер 8(1), С. 5137 - 5168

Опубликована: Март 20, 2024

El microbioma intestinal de las personas obesas suele mostrar diferencias en comparación con peso normal. Estas pueden estar relacionadas cambios la composición y diversidad bacterias que viven el intestino, así como función del microbioma. Objetivo: Analizar regulación su impacto obesidad. Diseño estudio: La metodología aplicada fue revisión bibliográfica. Búsqueda información: Se logró acceder mediante buscadores científicos PubMed Central; Scielo, Google académico. Resultados: pudo obtener esta enfermedad altera homeostasis ser humano. Provoca enfermedades inflamatorias, autoinmunes, metabólicas neoplásicas, algunos trastornos conducta. También se encontró metabolismo, absorción nutrientes, recolección energía dieta, también regula sistema inmunológico. obtuvieron resultados los probióticos usan para regular microbiota endógena, mayor uso son siguientes modular funciones influyen al mejorar metabolismo energético lipólisis. Conclusión: ha demostrado está relacionada incluida capacidad cuerpo alimentos.

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