Nanoparticles in cancer theragnostic and drug delivery: A comprehensive review

Life Sciences, Год журнала: 2024, Номер 352, С. 122899 - 122899

Опубликована: Июль 9, 2024

This comprehensive review provides an in-depth analysis of how nanotechnology has revolutionized cancer theragnostic, which combines diagnostic and therapeutic methods to customize treatment. The study examines the unique attributes, uses, difficulties linked different types nanoparticles, including gold, iron oxide, silica, Quantum dots, Carbon nanotubes, liposomes, in context In addition, paper progression nanotheranostics, emphasizing its uses precise medication administration, photothermal therapy, sophisticated such as MRI, CT, fluorescence imaging. Moreover, article highlights capacity nanoparticles improve effectiveness drugs, reduce overall toxicity body, open up new possibilities for treating by releasing drugs a controlled manner targeting specific areas. Furthermore, it tackles concerns regarding compatibility their potential harmful effects, significance continuous nanotherapeutic use medical treatments. finishes outlining future applications predictive oncology customized medicine.

Язык: Английский

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Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5842 - 5842

Опубликована: Май 27, 2024

This study provides a brief discussion of the major nanopharmaceuticals formulations as well impact nanotechnology on future pharmaceuticals. Effective and eco-friendly strategies biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) outlined. paper discusses need use natural resources for “green” design new with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, preparation nanomaterials must be carefully considered. Therefore, safety long-term effects not overlooked. The testing represents an essential point their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent valuable, bioinspired model nanopharmaceutical that avoids using animals. Nanoformulations critical various fields, especially pharmacy, medicine, agriculture, material science, due unique properties advantages over conventional allows improved solubility, bioavailability, targeted drug delivery, controlled release, reduced toxicity. have transitioned from experimental stages being vital component clinical practice, significantly improving outcomes medical fields cancer treatment, infectious diseases, neurological disorders, personalized advanced diagnostics. Here key points highlighting importance. significant challenges, opportunities, directions mentioned final section.

Язык: Английский

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Emerging Nanoparticle-Based Diagnostics and Therapeutics for Cancer: Innovations and Challenges

Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 70 - 70

Опубликована: Янв. 7, 2025

Malignant growth is expected to surpass other significant causes of death as one the top reasons for dismalness and mortality worldwide. According a World Health Organization (WHO) study, this illness approximately between 9 10 million instances deaths annually. Chemotherapy, radiation, surgery are three main methods treating cancer. These seek completely eradicate all cancer cells while having fewest possible unintended impacts on healthy cell types. Owing lack target selectivity, majority medications have substantial side effects. On hand, nanomaterials transformed identification, diagnosis, management Nanostructures with biomimetic properties been grown late, fully intent observing sickness. nanostructures be consumed by in areas profound disease. Furthermore, because their extraordinary physicochemical properties, which incorporate nanoscale aspects, more prominent surface region, explicit geometrical features, ability embody different substances within or outside surfaces, remarkable nano-vehicles conveying restorative specialists designated regions. This review discusses recent developments nanostructured materials such graphene, dendrimers, cell-penetrating peptide nanoparticles, nanoliposomes, lipid magnetic nano-omics diagnosis

Язык: Английский

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Potential of Chitosan/Gelatin-Based Nanofibers in Delivering Drugs for the Management of Varied Complications: A Review

Polymers, Год журнала: 2025, Номер 17(4), С. 435 - 435

Опубликована: Фев. 7, 2025

Drug delivery systems have revolutionized traditional drug administration methods by addressing various challenges, such as enhancing solubility, prolonging effectiveness, minimizing adverse effects, and preserving potency. Nanotechnology-based systems, particularly nanoparticles (NPs) nanofibers (NFs), emerged promising solutions for biomedicine delivery. NFs, with their ability to mimic the porous fibrous structures of biological tissues, garnered significant interest in drug-delivering applications. Biopolymers gelatin (Ge) chitosan (CH) gained much more attention due biocompatibility, biodegradability, versatility biomedical CH exhibits exceptional anti-bacterial activity, wound healing capabilities, whereas Ge provides good biocompatibility cell adhesion properties. Ge/CH-based NFs stimulate cellular connections facilitate tissue regeneration owing structural resemblance extracellular matrix. This review explores additive preparation, including electrospinning, force pinning, template synthesis, focusing on electrospinning factors influencing fiber structure. The properties CH, role release, formulation strategies, characterization techniques electrospun fibers are discussed. Furthermore, this addresses applications delivering active moieties management orthopedics regulatory considerations, along challenges related them. Thus, aims provide a comprehensive overview potential

Язык: Английский

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Enhancing biocompatibility and functionality: Carbon nanotube-polymer nanocomposites for improved biomedical applications

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 99, С. 105958 - 105958

Опубликована: Июль 9, 2024

Язык: Английский

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Recent Advancements in Metallic Au- and Ag-Based Chitosan Nanocomposite Derivatives for Enhanced Anticancer Drug Delivery

Molecules, Год журнала: 2024, Номер 29(10), С. 2393 - 2393

Опубликована: Май 19, 2024

The rapid advancements in nanotechnology the field of nanomedicine have potential to significantly enhance therapeutic strategies for cancer treatment. There is considerable promise enhancing efficacy therapy through manufacture innovative nanocomposite materials. Metallic nanoparticles been found release anticancer medications that are loaded onto them, resulting a sustained release, hence reducing dosage required drug administration and preventing their buildup healthy cells. combination with biocompatible materials offers new prospects development advanced therapies exhibit enhanced selectivity, reduced adverse effects, improved patient outcomes. Chitosan (CS), polysaccharide possessing distinct physicochemical properties, exhibits favorable attributes controlled delivery due its biocompatibility biodegradability. nanocomposites heightened stability, biocompatibility, prolonged characteristics medicines. incorporation gold (Au) into chitosan results manifestation photothermal characteristics, whereas inclusion silver (Ag) boosts antibacterial capabilities synthesized nanocomposite. objective this review investigate recent progress utilization Ag Au nanoparticles, or thereof, within matrix modified derivatives purpose delivery. research findings deliver various drugs, such as doxorubicin, 5-Fluroacil, curcumin, paclitaxel, 6-mercaptopurine, were investigated. Moreover, modifications carried out on phase surfaces targeting loading efficiency, pH sensitivity highlighted. In addition, challenges perspectives could motivate further related applications summarized.

Язык: Английский

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Enhanced pharmacokinetic approach for anastrozole in macromolecule-based silk fibroin nanoparticles incorporated in situ injectables for estrogen-positive breast cancer therapy

Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 28

Опубликована: Янв. 3, 2025

Breast cancer (BC) is a substantial reason for cancer-related mortality among women across the globe. Anastrozole (ANS) an effective orally administered hormonal therapy estrogen+ (ER+) BC treatment. However, several side effects and pharmacokinetic limitations restricted its uses in Therefore, this study developed

Язык: Английский

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Exploring the Potential of Gold Nanoparticles in Proton Therapy: Mechanisms, Advances, and Clinical Horizons

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 176 - 176

Опубликована: Янв. 30, 2025

Proton therapy represents a groundbreaking advancement in cancer radiotherapy, leveraging the unique spatial energy distribution of protons to deliver precise, high-dose radiation tumors while sparing surrounding healthy tissues. Despite its clinical success, proton faces challenges optimizing therapeutic precision and efficacy. Recent research has highlighted potential gold nanoparticles enhance outcomes. Due their high atomic number favorable biological properties, act as radiosensitizers by amplifying generation secondary electrons reactive oxygen species upon irradiation. This enhances DNA damage tumor cells preserving Additionally, functionalization with tumor-targeting ligands offers improved precision, making more effective against broader range cancers. review synthesizes current knowledge on mechanisms nanoparticle radiosensitization, preclinical evidence, technological hurdles that must be addressed integrate this promising approach into practice, aiming advance efficacy accessibility therapy.

Язык: Английский

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Amine-functionalized mesoporous silica nanoparticles decorated by silver nanoparticles for delivery of doxorubicin in breast and cervical cancer cells

European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2024, Номер 201, С. 114349 - 114349

Опубликована: Июнь 5, 2024

Nanocarriers have demonstrated promising potential in the delivery of various anticancer drugs and improving efficiency treatment. In this study, silver nanoparticles (AgNPs) were green-synthesized using extracts different parts pomegranate plant, including peel, flower petals, calyx. To obtain most efficient extract used for green synthesis AgNPs, all three types synthesized characterized. Then, (3-Aminopropyl) triethoxysilane-functionalized mesoporous silica (MSNs-APTES) decorated with AgNPs fabricated via a one-pot green-synthesis method. directly coated on surface MSNs-APTES by adding enriched source reducing agent leading to converting ion AgNPs. The MSN-APTES-AgNPs (MSNs-AgNPs) been thoroughly characterized nanoparticle characterization techniques. addition, DNA cleavage hemolysis activities analyzed, confirming biocompatibility nanoparticles. Doxorubicin (DOX, as breast/cervical anti-cancer drug) loading (42.8%) release profiles investigated UV–visible spectroscopy. fibroblast, breast cancer, cervical cancer cells' viability against DOX-loaded also studied. results high drug loading, uniform shape, small functionalized its great management.

Язык: Английский

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Advancements in Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Breast Cancer Therapy

Current Pharmaceutical Design, Год журнала: 2024, Номер 30(37), С. 2922 - 2936

Опубликована: Авг. 16, 2024

Solid Lipid Nanocarriers (SLNs) offer a promising avenue for breast cancer treatment, disease that accounts 12.5% of global cases. Despite strides in combined therapies (surgery, chemotherapy, radiation, and endocrine therapy), challenges like systemic toxicity, drug resistance, adverse effects persist. The manuscript offers several novel contributions to the field treatment through use SLNs, these are innovative delivery systems, multifunctionality, biocompatibility, potential overcome integration with emerging therapies, focus on personalized medicine, ongoing future research directions reduced side effects. SLNs present strategy due their unique physicochemical properties. They can encapsulate both hydrophilic hydrophobic drugs, ensuring controlled release targeted delivery, thus enhancing solubility bioavailability reducing multifunctional nature improves while biocompatibility supports therapy. Challenges pharmacists include maintaining stability, effective loading, timed delivery. Combining gene immunotherapy holds promise more treatments. represent significant advancement, providing precise fewer effects, overcoming resistance. Ongoing will refine therapy, targeting cells minimal integrating other treatments comprehensive approaches. Advances nanotechnology medicine tailor specific subtypes, effectiveness. Clinical trials new developments crucial realizing SLNs' full care. In conclusion, transformative approach addressing issues aims optimize potentially revolutionizing care hope patients.

Язык: Английский

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