Acta Pharmacologica Sinica, Год журнала: 2024, Номер 45(6), С. 1130 - 1141
Опубликована: Янв. 9, 2024
Язык: Английский
Molecular Cancer, Год журнала: 2022, Номер 21(1)
Опубликована: Июль 18, 2022
Abstract The resistance of tumor cells to therapy severely impairs the efficacy treatment, leading recurrence and metastasis various cancers. Clarifying underlying mechanisms therapeutic may provide new strategies for overcoming cancer resistance. N6-methyladenosine (m6A) is most prevalent RNA modification in eukaryotes, involved regulation splicing, translation, transport, degradation, stability processing, thus affecting several physiological processes progression. As a novel type multifunctional non-coding RNAs (ncRNAs), circular (circRNAs) have been demonstrated play vital roles anticancer therapy. Currently, accumulating studies revealed mutual m6A circRNAs, their interaction can further influence sensitivity treatment. In this review, we mainly summarized recent advances circRNAs modulation resistance, as well interplay potential mechanisms, providing promising insights future directions reversal cancer.
Язык: Английский
Процитировано
87
Molecular Cancer, Год журнала: 2023, Номер 22(1)
Опубликована: Март 1, 2023
Abstract N6-methyladenosine (m 6 A) methylation is the most universal internal modification in eukaryotic mRNA. With elaborate functions executed by m A writers, erasers, and readers, modulation involved myriad physiological pathological processes. Extensive studies have demonstrated diverse tumours, with effects on tumorigenesis, metastasis, resistance. Recent evidence has revealed an emerging role of tumour immunoregulation, divergent patterns been microenvironment. To depict regulatory immune microenvironment (TIME) its effect evasion, this review focuses TIME, which characterized hypoxia, metabolic reprogramming, acidity, immunosuppression, outlines A-regulated TIME evasion under stimuli. Furthermore, anti-tumour cells are summarized.
Язык: Английский
Процитировано
58
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(22), С. 16484 - 16484
Опубликована: Ноя. 18, 2023
Hepatocellular carcinoma (HCC) is a highly fatal malignancy with limited therapeutic options and high recurrence rates. Recently, immunotherapeutic agents such as immune checkpoint inhibitors (ICIs) have emerged new paradigm shift in oncology. ICIs, programmed cell death protein 1 (PD-1) inhibitors, provided source of hope for patients advanced HCC. Yet, the eligibility criteria HCC ICIs are still missing piece puzzle. Circular RNAs (circRNAs) recently class non-coding that play fundamental role cancer pathogenesis. Structurally, circRNAs resistant to exonucleolytic degradation longer half-life than their linear counterparts. Functionally, possess capability influence various facets tumor microenvironment, especially at tumor–immune synapse. Notably, been observed control expression molecules within cells, potentially impeding effectiveness ICIs. Therefore, this renders them potential cancer-immune biomarkers diagnosis, prognosis, regimen determinants. In review, authors shed light on structure functional roles and, most importantly, highlight promising immunomodulation
Язык: Английский
Процитировано
56
Molecular Cancer, Год журнала: 2023, Номер 22(1)
Опубликована: Авг. 15, 2023
Abstract Glycolytic reprogramming is one of the most important features cancer and plays an integral role in progression cancer. In cells, changes glucose metabolism meet needs self-proliferation, angiogenesis lymphangiogenesis, metastasis, also affect immune escape, prognosis evaluation therapeutic effect The n6-methyladenosine (m6A) modification RNA widespread eukaryotic cells. Dynamic reversible m6A modifications are widely involved regulation stem cell renewal differentiation, tumor therapy resistance, microenvironment, metabolism. Lately, more evidences show that can glycolysis process tumors a variety ways to regulate biological behavior tumors. this review, we discussed genesis development, elaborated detail profound impact on different by regulating glycolysis. We believe modified has great significance potential for treatment.
Язык: Английский
Процитировано
48
Nature reviews. Cancer, Год журнала: 2024, Номер 24(9), С. 597 - 613
Опубликована: Июль 29, 2024
Язык: Английский
Процитировано
47
Cell Proliferation, Год журнала: 2022, Номер 56(1)
Опубликована: Окт. 1, 2022
Circular RNAs (circRNAs) are a subclass of noncoding RNAs, playing essential roles in tumorigenesis and aggressiveness. Recent studies have revealed the pivotal functions circ-CTNNB1 (a circular RNA derived from CTNNB1) cancer progression. However, little is known about role osteosarcoma (OS), highly malignant bone tumour children adolescents.Circ-CTNNB1 was analysed by qRT-PCR, results were confirmed Sanger sequencing. The interaction effects between binding motif protein 15 (RBM15) through biotin-labelled pull-down mass spectrometry, vitro binding, electrophoretic mobility shift assays. In vivo experiments performed to evaluate biological underlying mechanisms RBM15 OS cells.Circ-CTNNB1 expressed tissues predominantly detected nucleus cells. Ectopic expression promoted growth, invasion, metastasis cells vivo. Mechanistically, interacted with subsequently hexokinase 2 (HK2), glucose-6-phosphate isomerase (GPI) phosphoglycerate kinase 1 (PGK1) N6-methyladenosine (m6A) modification facilitate glycolysis process activate progression.Circ-CTNNB1 drives aerobic progression facilitating RBM15-mediated m6A modification.
Язык: Английский
Процитировано
51
Cancer Letters, Год журнала: 2023, Номер 566, С. 216245 - 216245
Опубликована: Май 27, 2023
Язык: Английский
Процитировано
39
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 162, С. 114669 - 114669
Опубликована: Апрель 8, 2023
N6-methyladenosine (m6A) modification, as one of the most common types inner RNA modification in eukaryotes, plays a multifunctional role normal and abnormal biological processes. This type is modulated by m6A writer, eraser reader, which turn impact various processes metabolism, such processing, translation, nuclear export, localization decay. The current academic view holds that exerts crucial post-transcriptional modulation gene expression, involved multiple cellular functions, developmental disease However, potential molecular mechanism specific development liver have not been fully elucidated. In our review, we summarized latest research progress on disease, explored how these novel findings reshape knowledge metabolism. addition, also illustrated effect regeneration to prompt further exploration physiology pathology, providing new insights references for search therapeutic targets disease.
Язык: Английский
Процитировано
30
The Innovation, Год журнала: 2023, Номер 4(4), С. 100452 - 100452
Опубликована: Май 29, 2023
•RNA modification is a novel hotspot of epigenetic research, affecting wide range physiological and pathological processes.•RNA plays an important role in tumor immunity.•RNA may be potential clinical therapeutic target to prevent immune escape. An immunosuppressive state typical feature the microenvironment. Despite dramatic success checkpoint inhibitor (ICI) therapy preventing cell escape from surveillance, primary acquired resistance have limited its use. Notably, recent trials shown that drugs can significantly improve outcome ICI various cancers, indicating importance modifications regulation tumors. Recently, RNA (N6-methyladenosine [m6A], N1-methyladenosine [m1A], 5-methylcytosine [m5C], etc.), areas been play crucial roles protumor antitumor immunity. In this review, we provide comprehensive understanding how m6A, m1A, m5C function immunity by directly regulating different cells as well indirectly through mechanisms, including modulating expression checkpoints, inducing metabolic reprogramming, secretion immune-related factors. Finally, discuss current status strategies targeting escape, highlighting their potential.
Язык: Английский
Процитировано
26
Cell Death and Disease, Год журнала: 2024, Номер 15(5)
Опубликована: Май 2, 2024
Abstract Cancer immunotherapy has rapidly transformed cancer treatment, yet resistance remains a significant hurdle, limiting its efficacy in many patients. Circular RNAs (circRNAs), novel class of non-coding RNAs, have emerged as pivotal regulators gene expression and cellular processes. Increasing evidence indicates their involvement modulating to immunotherapy. Notably, certain circRNAs function miRNA sponges or interact with proteins, influencing the immune-related genes, including crucial immune checkpoint molecules. This, turn, shapes tumor microenvironment significantly impacts response In this comprehensive review, we explore evolving role orchestrating immunotherapy, specific focus on mechanisms expression. Additionally, underscore potential promising therapeutic targets augment effectiveness Understanding could contribute development new strategies overcome improve patient outcomes.
Язык: Английский
Процитировано
17