Twice evasions of Omicron variants explain the temporal patterns in six Asian and Oceanic countries

BMC Infectious Diseases, Год журнала: 2023, Номер 23(1)

Опубликована: Янв. 13, 2023

The ongoing coronavirus 2019 (COVID-19) pandemic has emerged and caused multiple waves in the following six countries: India, Indonesia, Nepal, Malaysia, Bangladesh Myanmar. Some of countries have been much less studied this devastating pandemic. This study aims to assess impact Omicron variant these estimate infection fatality rate (IFR) reproduction number [Formula: see text] South Asia, Southeast Asia Oceania countries.We propose a Susceptible-Vaccinated-Exposed-Infectious-Hospitalized-Death-Recovered model with time-varying transmission fit COVID-19 IFR aforementioned countries. level immune evasion intrinsic transmissibility advantage are also considered model.We our reported deaths well. We (in range 0.016 0.136%) 0 9) Multiple each country were observed simulation results.The invasion new higher suggests variant. Our forecast implies that wave may be mitigated due increasing immunized population vaccine coverage.

Язык: Английский

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Assessing and bridging the gap in vaccinology education: insights from Romanian medical universities

BMC Medical Education, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 26, 2025

Язык: Английский

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Evaluation of FIB-4, NFS, APRI and Liver Function Tests as Predictors for SARS-CoV-2 Infection in the Elderly Population: A Matched Case-Control Analysis

Journal of Clinical Medicine, Год журнала: 2022, Номер 11(17), С. 5149 - 5149

Опубликована: Авг. 31, 2022

Several investigations have revealed that COVID-19 causes a significant death rate due to acute respiratory distress syndrome, alterations in the quantity of ACE2 receptor expression, or intensity cytokine storm. Similarly, patients with hepatic impairment are co-infected SARS-CoV-2 more likely display upregulations receptors and storm overload, which exacerbates impairment, potentially increasing rate. Moreover, it is expected aging population develops higher degree fibrosis association other comorbid conditions influence course COVID-19. Therefore, this research was developed describe differences liver test parameters elderly individuals relation inflammatory markers outcomes. This current observational single-center followed case-control design hospitalized for infection. The conducted at tertiary emergency hospital western Romania during two-year period. There were 632 included analysis split into two equal groups matched 1:1 based on gender body mass index. Three hundred sixteen made group cases older than 65 years, while half 316 patient controls younger years old. Disease outcomes showed prevalence ICU admissions (22.8% vs. 12.7%, p-value < 0.001) in-hospital mortality (17.1% 8.9%, = 0.002) cases. Specific non-specific biomarkers identified as risk factors elderly, such ALP (OR 1.26), LDH 1.68), AST 1.98), ALT 2.34). APRI NFS scores 1.5 were, respectively, 2.69 times and, 3.05 die from COVID-19, FIB-4 3.25 3.13 hospitalization Our indicates abnormally increased high related worse prognosis infected individuals.

Язык: Английский

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Adoption rates of recommended vaccines and influencing factors among patients with inflammatory arthritis: a patient survey

Rheumatology International, Год журнала: 2023, Номер 44(1), С. 165 - 172

Опубликована: Окт. 14, 2023

Язык: Английский

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Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Journal of Infection and Public Health, Год журнала: 2024, Номер 17(3), С. 467 - 473

Опубликована: Янв. 17, 2024

Despite the well-known efficacy of anti-COVID-19 vaccines in preventing morbidity and mortality, several vaccinated individuals are diagnosed with SARS-CoV-2 breakthrough infection, which might require hospitalisation. This multicentre, observational, retrospective study aimed to investigate clinical characteristics outcomes vs. non-vaccinated patients, both hospitalised infection 3 major hospitals Northern Italy. Data collection was retrospective, paper electronic medical records adult patients a were pseudo-anonymised analysed. Vaccinated manually paired, using predetermined matching criterion (similar age, gender, date hospitalisation). Demographic, clinical, treatment, outcome data compared between groups differing by vaccination status Pearson's Chi-square Mann-Whitney tests. Moreover, multiple logistic regression analyses performed assess impact on ICU admission or intra-hospital mortality. from 360 collected. presented higher prevalence relevant comorbidities, like kidney replacement therapy haematological malignancy, despite milder presentation at first evaluation. Non-vaccinated required intensive care more often than their counterparts (8.8% 1.7%, p = 0.002). Contrariwise, no difference mortality observed two (19% 20%, 0.853). These results confirmed multivariable regressions, showed that significantly associated decreased risk (aOR=0.172, 95%CI: 0.039-0.542, 0.007), but not (aOR=0.996, 0.582-1.703, 0.987). provides real-world COVID-19 Our suggest has protective role profiles, especially regarding need for admission. findings contribute our understanding among emphasise importance severe disease, particularly those countries lower first-booster uptake rates.

Язык: Английский

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Preference and Willingness to Pay for the Regular COVID-19 Booster Shot in the Vietnamese Population: Theory-Driven Discrete Choice Experiment

JMIR Public Health and Surveillance, Год журнала: 2022, Номер 9, С. e43055 - e43055

Опубликована: Дек. 31, 2022

The COVID-19 booster vaccination rate has declined despite the wide availability of vaccines. As is becoming endemic and charges for regular are being introduced, measuring public acceptance willingness to pay boosters ever more crucial.This study aims (1) investigate boosters, (2) assess a shot, (3) identify factors associated with vaccine hesitancy. Our results will provide crucial insights into implications policy response as well development feasible effective campaign during Vietnam's waning immunity period.A cross-sectional was conducted among 871 Vietnamese online participants from April August 2022. An questionnaire based on discrete choice experiment (DCE) design developed, distributed using snowball sampling method, subsequently conjointly analyzed Qualtrics platform. A history infection vaccination, health status, vaccinate, pay, other were examined.Among participants, 761 (87.4%) had received or waiting shot. However, low at US $8.02, most indicated an unwillingness (n=225, 25.8%) only half costs (n=222, 25.4%). Although information insufficiency wariness toward vaccines long-term side effects, duration, mortality attributes concerned decision-making period. Participants who children less than 18 years old in their homes infected lower (odds ratio [OR] 0.54, 95% CI 0.39-0.74). Respondents under 12 family least 1 dose higher (OR 2.03, 1.12-3.66). burden medical expenses 0.33, 0.25-0.45) fear 0.93, 0.86-1.00) negative level pay.A significant inconsistency between high underscores role trust. In addition raising awareness about concerning characteristics booster, social media listening should be used collaboration professionals establish 2-way exchange. Work incentives suitable mandates continue encourage workforce participation. Most importantly, all interventions informational transparency strengthen trust authorities.

Язык: Английский

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A national survey of parents’ views on childhood vaccinations in Ireland

Vaccine, Год журнала: 2023, Номер 41(25), С. 3740 - 3754

Опубликована: Май 13, 2023

Язык: Английский

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Heterologous vaccination with inactivated vaccine and mRNA vaccine augments antibodies against both spike and nucleocapsid proteins of SARS-CoV-2: a local study in Macao

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Май 12, 2023

The mRNA vaccines (RVs) can reduce the severity and mortality of severe acute respiratory syndrome coronavirus (SARS-CoV-2). However, almost only inactivated (IVs) but no RVs had been used in mainland China until most recently, relaxing its anti-pandemic strategies December 2022 increased concerns about new outbreaks. In comparison, many citizens Macao Special Administrative Region received three doses IV (3IV) or RV (3RV), 2 plus one booster (2IV+1RV). By end 2022, we recruited 147 participants with various vaccinations detected antibodies (Abs) against spike (S) protein nucleocapsid (N) virus as well neutralizing (NAb) their serum. We observed that level anti-S Ab NAb was similarly high both 3RV 2IV+1RV lower 3IV. contrast, anti-N highest 3IV like convalescents, intermediate 2IV+1RV, lowest 3RV. Whereas significant differences basal levels cytokines related to T-cell activation were among vaccination groups before after boosters. No vaccinees reported adverse events. Since took stringent non-pharmaceutical interventions world, this study possesses much higher confidence results than other studies from highly infected regions. Our findings suggest heterologous outperforms homologous it induces not (to 3RV) also (via IV). It combines advantages block viral entry) intervene subsequent pathological processes such intracellular replication interference signal transduction hence biological functions host cells).

Язык: Английский

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Multilevel evidence for institutional trust and vaccine confidence in 134 countries: moderating effects of cultural religiosity and individualism

Current Psychology, Год журнала: 2023, Номер 43(20), С. 18898 - 18907

Опубликована: Авг. 12, 2023

Язык: Английский

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Colchicine and risk of hospitalization due to COVID‐19: A population‐based study

Journal of Medical Virology, Год журнала: 2023, Номер 95(2)

Опубликована: Янв. 14, 2023

Abstract Colchicine is one of the most widely studied and best‐known anti‐inflammatory treatments. This study aimed to assess effect colchicine on risk hospitalization due COVID‐19; its susceptibility severity virus in patients with COVID‐19. We carried out a population‐based case‐control study. The following groups were applied: (1) , cases positive PCR who hospitalized COVID‐19, controls without PCR; (2) (hospitalized non‐hospitalized), same controls; (3) determine potential subjects COVID‐19 hospitalized, nonhospitalised. Different electronic, linked, administrative health clinical databases used extract data sociodemographic variables, comorbidities, medications dispensed. covered 3060 26 757 not 56 785 healthy controls. After adjustment for comorbidities other treatments, did modify (adjusted odd ratio [OR] 1.08 [95% confidence interval (CI) 0.76−1.53]), patients' contracting disease OR 1.12 (95% CI 0.91−1.37)) or infection 1.03 0.67−1.59]). Our results would neither support prophylactic use prevention any type patient, nor justify withdrawal treatment higher

Язык: Английский

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