Mucosal Immunology, Год журнала: 2022, Номер 15(6), С. 1143 - 1157
Опубликована: Авг. 24, 2022
Язык: Английский
Investigative Ophthalmology & Visual Science, Год журнала: 2018, Номер 59(14), С. DES192 - DES192
Опубликована: Ноя. 27, 2018
Purpose: Dry eye is a major ocular pathology worldwide. Although dry multifactorial disease, recent studies have shown that chronic immunologic processes pivotal role in its pathogenesis, characterized by the infiltration of immune cells lacrimal glands, elevated levels tear inflammatory cytokines, and increased density cornea conjunctiva. This review describes advances understanding relationship between inflammation. Methods: narrative based on searches international literature using terms related to response eye, includes clinical trials, animal experiments, expert reviews. Results: presents clinically as film instability associated with corneal/conjunctival epithelial disorders, Meibomian gland dysfunction, decreased visual function, laboratory indicated inflammation conjunctiva, cornea, aqueous tears. Furthermore, at these locations leads conjunctival goblet cell apoptosis, corneal barrier disruption, nerve damage. These outcomes can be exacerbated intrinsic extrinsic factors, such aging, sex steroid hormone, autoimmune diseases, contact lens use, display terminals, environment. Conclusions: Recent research revealed process which has been proposed an “inflammatory vicious cycle” eye. Comprehensive assessment will improve selection treatments help break cycle settings.
Язык: Английский
Процитировано
210
Oxidative Medicine and Cellular Longevity, Год журнала: 2019, Номер 2019, С. 1 - 22
Опубликована: Фев. 12, 2019
Oxidative stress and inflammation play a critical role in the initiation progression of age-related ocular abnormalities as cataract, glaucoma, diabetic retinopathy, macular degeneration. Therefore, phytochemicals with proven antioxidant anti-inflammatory activities, such carotenoids polyphenols, could be benefit these diseases. We searched PubMed Web Science databases for original studies investigating benefits different polyphenols ophthalmic Our results showed that several (such anthocyanins, Ginkgo biloba , quercetin, resveratrol) lutein, zeaxanthin, mezoxanthin) have shown significant preventive therapeutic against aforementioned conditions. The involved mechanisms findings include mitigating production reactive oxygen species, inhibiting tumor necrosis factor- α vascular endothelial growth factor pathways, suppressing p53-dependent apoptosis, inflammatory markers, interleukin- (IL-) 8, IL-6, IL-1a, leucocyte adhesion molecule-1. Consumption products containing may protective diseases; however, adequate human data are lacking. This review discusses their possible synergistic effects on prevention treatment eye diseases induced or augmented by oxidative inflammation.
Язык: Английский
Процитировано
198
Experimental Eye Research, Год журнала: 2020, Номер 197, С. 108115 - 108115
Опубликована: Июнь 16, 2020
Язык: Английский
Процитировано
198
Clinical Immunology, Год журнала: 2019, Номер 203, С. 81 - 121
Опубликована: Апрель 29, 2019
Язык: Английский
Процитировано
190
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 196, С. 114770 - 114770
Опубликована: Март 7, 2023
Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of over 43 million blindness. However, efficient drug delivery to treat ocular diseases, particularly intraocular disorders, remains huge challenge due multiple barriers that significantly the ultimate therapeutic efficacy drugs. Recent advances in nanocarrier technology offer promising opportunity overcome these by providing enhanced penetration, increased retention, improved solubility, reduced toxicity, prolonged release, targeted loaded eyes. This review primarily provides an overview progress contemporary applications nanocarriers, mainly polymer- lipid-based treating various eye highlighting their value achieving delivery. Additionally, covers administration routes, as well prospective future developments challenges field nanocarriers for diseases.
Язык: Английский
Процитировано
140
European Journal of Pharmaceutical Sciences, Год журнала: 2022, Номер 175, С. 106206 - 106206
Опубликована: Май 11, 2022
Dry eye disease (DED), keratoconjunctivitis sicca or dysfunctional tear syndrome, is the most prevalent ophthalmic which affects a substantial segment of people worldwide with increasing frequency. It considered multifactorial ocular surface and film, characterized by variation signs symptoms. The symptoms range from mild to severe itching, burning, irritation, fatigue, inflammation that may lead potential damage cornea, conjunctiva even vision loss. Correspondingly, depending on different manifestations pathophysiology, treatment must be tailored specifically each patient targeting specific mechanisms implicated in their disease. Currently, there are several medical products techniques available under investigation for DED. present article focused pathophysiology DED, new diagnostic approach recently developed drug delivery systems devices reducing progress treating causes.
Язык: Английский
Процитировано
101
Advanced Science, Год журнала: 2022, Номер 9(17)
Опубликована: Апрель 18, 2022
Abstract Dry eye disease (DED) impacts ≈30% of the world's population and causes serious ocular discomfort even visual impairment. Inflammation is one core cause DED vicious cycle, a multifactorial deterioration in process. However, there are also reactive oxygen species (ROS) regulating inflammation other points cycle from upstream, leading to treatment failure current therapies merely targeting inflammation. Accordingly, authors develop micelle‐based drops (more specifically p38 mitogen‐activated protein kinases (MAPK) inhibitor Losmapimod (Los)‐loaded ROS scavenger Tempo (Tem)‐conjugated cationic polypeptide micelles, designated as MTem/Los) for safe efficient management. Cationic MTem/Los improve retention conjugated water‐soluble Tem loaded water‐insoluble Los via electrostatic interaction with negatively charged mucin on cornea, enabling an increase therapeutic efficiency decrease dosing frequency. Mechanistically, effectively over‐production, reduce expression proinflammatory cytokines chemokines, restrain macrophage phenotypic transformation, inhibit cell apoptosis. Therapeutically, dual‐functional suppress inflammatory response, reverse corneal epithelial defect, save goblet dysfunction, recover tear secretion, thus breaking alleviating DED. Moreover, exhibit excellent biocompatibility tolerability potential application simple rapid oxidative stress‐ inflammation‐induced disorders, including
Язык: Английский
Процитировано
100
Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)
Опубликована: Июль 22, 2023
Abstract Ocular drug delivery has constantly challenged ophthalmologists and scientists due to various anatomical physiological barriers. Static dynamic ocular barriers prevent the entry of exogenous substances impede therapeutic agents' active absorption. This review elaborates on anatomy eye associated constraints. Followed by an illustration some common diseases, including glaucoma their current clinical therapies, emphasizing significance therapy in treating diseases. Subsequently, advances modalities, especially nanotechnology-based systems, are recommended, typical research is highlighted. Based related research, systematic comprehensive characterizations nanocarriers summarized, hoping assist with future research. Besides, we summarize ophthalmic drugs currently market or still trials recent patents nanocarriers. Finally, inspired trends concepts, provide insight into challenges faced novel systems further put forward directions for We hope this can inspiration motivation better design development formulations. Graphical abstract
Язык: Английский
Процитировано
87
Pharmaceuticals, Год журнала: 2024, Номер 17(1), С. 104 - 104
Опубликована: Янв. 11, 2024
Pyrimidines have become an increasingly important core structure in many drug molecules over the past 60 years. This article surveys recent areas which pyrimidines had a major impact discovery therapeutics, including anti-infectives, anticancer, immunology, immuno-oncology, neurological disorders, chronic pain, and diabetes mellitus. The presents synthesis of medicinal agents highlights role biological target with respect to disease model. Additionally, potency, ADME properties pharmacokinetics/pharmacodynamics (if available) are discussed. survey attempts demonstrate versatility pyrimidine-based drugs, not only for their potency affinity but also improved chemistry pyrimidine as bioisostere phenyl other aromatic π systems. It is hoped that this will provide insight researchers considering scaffold chemotype future candidates order counteract medical conditions previously deemed untreatable.
Язык: Английский
Процитировано
39
Nano-Micro Letters, Год журнала: 2024, Номер 16(1)
Опубликована: Фев. 19, 2024
Dry eye disease (DED) is a major ocular pathology worldwide, causing serious discomfort and even visual impairment. The incidence of DED gradually increasing with the high-frequency use electronic products. Although inflammation core cause vicious cycle, reactive oxygen species (ROS) play pivotal role in cycle by regulating from upstream. Therefore, current therapies merely targeting show failure treatment. Here, novel dual-atom nanozymes (DAN)-based drops are developed. antioxidative DAN successfully prepared embedding Fe Mn bimetallic single-atoms N-doped carbon material modifying it hydrophilic polymer. vitro vivo results demonstrate endowed superior biological activity scavenging excessive ROS, inhibiting NLRP3 inflammasome activation, decreasing proinflammatory cytokines expression, suppressing cell apoptosis. Consequently, effectively alleviate inflammation, promote corneal epithelial repair, recover goblet density tear secretion, thus breaking cycle. Our findings open an avenue to make as intervention form ROS-mediated inflammatory diseases.
Язык: Английский
Процитировано
25