Taiwan Journal of Ophthalmology,
Год журнала:
2023,
Номер
13(1), С. 3 - 12
Опубликована: Янв. 1, 2023
Dry
eye
disease
(DED)
is
a
common
chronic
ocular
disease.
DED
can
have
significant
impact
on
visual
function,
causing
disturbances
to
comfort,
daily
activities,
and
general
quality
of
life.
The
varied
nature
makes
it
difficult
point
specific
cause
the
syndrome.
However,
current
literature
agrees
that
inflammation
cornea
conjunctiva
plays
major
role
in
its
pathogenesis.
Therapies
targeted
toward
shown
success
treatment
DED.
purpose
this
review
provide
an
overview
prevalence
inflammatory
pathophysiology
discussion
available
anti-inflammatory
therapies
including
following:
Nonsteroidal
drugs,
corticosteroids,
other
hormonal
therapies,
nonsteroidal
immunomodulators,
biological
tear
replacement,
antibiotics,
dietary
supplements,
tea
tree
oil,
intense
pulsed
light.
Biomedicine & Pharmacotherapy,
Год журнала:
2020,
Номер
130, С. 110577 - 110577
Опубликована: Авг. 4, 2020
The
risk
of
blue
light
exposure
to
human
health
has
attracted
increased
research
attention.
Blue
light,
with
relatively
high
energy,
can
cause
irreversible
photochemical
damage
eye
tissue.
Excessive
the
tends
a
series
alterations,
such
as
oxidative
stress,
mitochondrial
apoptosis,
inflammatory
apoptosis
and
DNA
damage,
resulting
in
development
dry
disease,
glaucoma,
keratitis.
Accordingly,
physical
protection,
chemical
pharmaceutical
protective
measures,
gene
therapy,
other
methods
are
widely
used
clinical
treatment
hazard.
We
reviewed
studies
on
possible
light-induced
signaling
pathways
mechanisms
summarized
therapeutic
approaches
addressing
Ophthalmology and Therapy,
Год журнала:
2023,
Номер
12(2), С. 755 - 788
Опубликована: Фев. 18, 2023
Exposure
to
blue
light
has
seriously
increased
in
our
environment
since
the
arrival
of
emitting
diodes
(LEDs)
and,
recent
years,
proliferation
digital
devices
rich
light.
This
raises
some
questions
about
its
potential
deleterious
effects
on
eye
health.
The
aim
this
narrative
review
is
provide
an
update
ocular
and
discuss
efficiency
methods
protection
prevention
against
light-induced
injury.
search
relevant
English
articles
was
conducted
PubMed,
Medline,
Google
Scholar
databases
until
December
2022.
Blue
exposure
provokes
photochemical
reactions
most
tissues,
particular
cornea,
lens,
retina.
In
vitro
vivo
studies
have
shown
that
certain
exposures
(depending
wavelength
or
intensity)
can
cause
temporary
permanent
damage
structures
eye,
especially
However,
currently,
there
no
evidence
screen
use
LEDs
normal
are
human
Regarding
protection,
currently
a
beneficial
effect
blocking
lenses
for
diseases,
age-related
macular
degeneration
(AMD).
humans,
pigments
(composed
lutein
zeaxanthin)
represent
natural
by
filtering
light,
be
through
intake
from
foods
food
supplements.
These
nutrients
associated
with
lower
risk
AMD
cataract.
Antioxidants
such
as
vitamins
C,
E,
zinc
might
also
contribute
preventing
oxidative
stress.
Currently,
at
domestic
intensity
levels
retinotoxic
eye.
toxicity
long-term
cumulative
dose-response
unknown.
Journal of Ocular Pharmacology and Therapeutics,
Год журнала:
2020,
Номер
36(3), С. 137 - 146
Опубликована: Март 16, 2020
Homeostasis
of
the
lacrimal
functional
unit
is
needed
to
ensure
a
well-regulated
ocular
immune
response
comprising
innate
and
adaptive
phases.
When
system
excessively
stimulated
and/or
immunoregulatory
mechanisms
are
disrupted,
balance
between
phases
dysregulated
chronic
surface
inflammation
can
result,
leading
dry
eye
disease
(DED).
According
Tear
Film
Ocular
Surface
Society
Dry
Eye
Workshop
II
definition,
DED
multifactorial
disorder
characterized
by
impairment
loss
tear
homeostasis
(hyperosmolarity),
discomfort
or
pain,
neurosensory
abnormalities.
Dysregulated
responses
result
in
damage,
which
further
contributing
factor
pathology.
Several
therapeutics
available
break
vicious
circle
prevent
progression,
including
immunosuppressive
agents
(steroids)
immunomodulators
(cyclosporine
lifitegrast).
Given
inflammatory
nature
DED,
each
these
commonly
used
clinical
practice.
In
this
study,
we
review
immunopathology
molecular
cellular
actions
current
topical
inform
decision
making.
Asia-Pacific Journal of Ophthalmology,
Год журнала:
2020,
Номер
9(6), С. 491 - 497
Опубликована: Ноя. 1, 2020
Prolonged
and
continuous
daily
use
of
digital
screens,
or
visual
display
terminals
(VDTs),
has
become
the
norm
in
occupational,
educational,
recreational
settings.
An
increased
global
dependence
on
VDTs
led
to
a
rise
associated
complaints,
including
eye
strain,
ocular
dryness,
burning,
blurred
vision,
irritation,
name
few.
The
principal
causes
for
VDT-associated
discomfort
are
abnormalities
with
oculomotor/vergence
systems
dry
(DE).
This
review
focuses
latter,
as
advances
research
have
identified
symptomology
surface
parameters
that
shared
between
prolonged
VDT
users
DE,
particularly
evaporative
subtype.
Several
mechanisms
been
implicated
blink
anomalies,
damaging
light
emission
from
modern
devices,
inflammatory
changes.
presence
preexisting
DE
also
explored
an
inciting
exacerbating
factor.
We
associations
screens
damage,
therapeutic
options,
hoping
raise
awareness
this
entity
goal
reducing
morbidity
economic
impact
screen-associated
disability.
Stem Cell Research & Therapy,
Год журнала:
2019,
Номер
10(1)
Опубликована: Авг. 30, 2019
Exosomes,
nanosized
extracellular
vesicles
of
30–150
nm,
are
shed
by
almost
all
cell
types.
Bearing
proteins,
lipids,
RNAs,
and
DNAs,
exosomes
have
emerged
as
vital
biological
mediators
in
cell-to-cell
communication,
affecting
a
plethora
physiological
pathological
processes.
Particularly,
mounting
evidence
indicates
that
immunologically
active
can
regulate
both
innate
adaptive
immune
responses.
Herein,
we
review
recent
advances
the
research
several
immune-mediated
eye
diseases,
including
Sjögren's
syndrome
(SS)
dry
eye,
corneal
allograft
rejection,
autoimmune
uveitis,
age-related
macular
degeneration
(AMD).
Additionally,
discuss
potential
novel
biomarkers
drug
delivery
for
diagnosis
treatment
diseases.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(49)
Опубликована: Авг. 4, 2023
Abstract
Ocular
injuries
and
their
complications
represent
the
most
common
causes
of
visual
impairment.
For
ocular
surgery,
there
is
an
unmet
need
for
highly
transparent
bioadhesives
with
superior
adhesion,
biocompatibility,
regenerative
properties.
Herein,
a
novel
high‐transparent
bioadhesive
hydrogel
composed
gelatin
methacryloyl
(GelMA)
dopamine
methacrylamide
(DMA)
developed
by
in
situ
oxidative
free‐radical
polymerization.
This
overcomes
fundamental
weakness
mussel‐inspired
adhesive
copolymers
clinical
practice
combining
multiple
favorable
properties,
including
high
light
transmission,
mechanical
strength,
biocompatibility.
DMA
significantly
enhances
corneal
epithelial
cells
proliferation,
migration
on
GelMA,
prevents
accumulation
reactive
oxygen
species
(ROS)
cells.
In
rabbit
models
conjunctiva
transplantation,
able
to
decrease
inflammatory
response
fibrosis
formation
induced
suture
surgical
trauma.
addition,
stromal
defect
model
reveals
that
Gel/DMA
could
effectively
seal
defects,
accelerates
re‐epithelialization,
promotes
wound
healing.
Thus,
given
advantages
bioactivity
simple
preparation,
represents
promising
strategy
suture‐free
repair.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Sjögren's
syndrome‐related
dry
eye
(SSDE)
is
a
severe
subtype
characterized
by
significant
immune
cell
attacks
on
the
lacrimal
gland.
However,
delivering
immunosuppressive
drugs
to
glands
for
SSDE
therapy
safely
and
sustainably
poses
challenges
in
clinical
practice.
Herein,
ROS‐responsive
microneedle
patch
with
detachable
functionality
(CE‐MN)
developed
enable
straightforward
minimally
invasive
administration
gland
area
penetrating
periocular
skin.
CE‐MN
loaded
cyclosporin
A
anti‐inflammatory
drug
epigallocatechin
gallate,
latter
also
serving
as
cross‐linker
matrix.
Poly(N‐isopropylacrylamide‐co‐butylacrylate),
temperature‐sensitive
polymer
utilized
fabricate
separable
layers
that
allow
controlled
detachment
of
base
from
needle,
reducing
patient
discomfort.
capable
modulating
release
responding
ROS,
facilitating
on‐demand
release,
accumulation
Compared
traditional
drops,
facilitated
long‐acting
delivery
more
than
48
h,
demonstrating
potent
effects
an
mouse
model
scavenging
ROS
inhibiting
proliferation
Th1,
Th17
cells,
macrophages.
Overall,
this
potentially
offers
novel
approach
treating
other
ocular
chronic
diseases.
Scientific Reports,
Год журнала:
2020,
Номер
10(1)
Опубликована: Сен. 3, 2020
Abstract
The
present
study
was
set
out
to
address
the
therapeutic
efficacy
of
human
adipose
tissue
stem
cells
derived
extracellular
vesicles
(hADSC-Evs)
in
a
mouse
model
dry
eye
disease
and
investigate
underlying
mechanisms
involved.
hADSC-Evs
drops
were
topically
administered
mice
that
subjected
desiccating
stress
(DS).
Clinical
parameters
ocular
surface
damage
assessed
with
fluorescein
staining,
tear
production
PAS
staining.
For
vitro
studies,
cell
viability
assay
TUNEL
staining
performed
corneal
epithelial
(HCECs)
treated
under
hyperosmotic
media.
In
addition,
immunofluorescent
Real-time
PCR
(qRT-PCR)
Western
blots
used
evaluated
NLRP3,
ASC,
caspase-1,
IL-1β
expression
levels.
Compared
vehicle
control
mice,
topical
showed
decreased
defects,
increased
production,
goblet
loss,
as
well
reduced
inflammatory
cytokines
production.
vitro,
could
protect
HCECs
against
stress-induced
apoptosis.
Mechanistically,
treatment
suppressed
DS
induced
rises
NLRP3
inflammasome
formation,
caspase-1
activation
maturation.
conclusion,
effectively
suppress
response
alleviate
disease.
