Disruption of Dopamine Homeostasis Associated with Alteration of Proteins in Synaptic Vesicles: A Putative Central Mechanism of Parkinson’s Disease Pathogenesis DOI Creative Commons
Xuanxiang Jin, Xiaoli Si, Xiaoguang Lei

и другие.

Aging and Disease, Год журнала: 2023, Номер unknown

Опубликована: Янв. 1, 2023

Vestigial dopaminergic cells in PD have selectivity for a sub-class of hypersensitive neurons with the nigrostriatal dopamine (DA) tract. DA is modulated pre-synaptic nerve terminals to remain stable. To be specific, proteins at release sites that function synthesizing and packing cytoplasm, modulating reingestion, changing excitability neurons, display regional discrepancies uncover relevancy observed sensitivity neurodegenerative changes. Although reasons majority cases are still indistinct, heredity environment known us make significant influences. For decades, genetic analysis patients family promoted our comprehension pathogenesis great extent, which reveals correlative mechanisms including oxidative stress, abnormal protein homeostasis mitochondrial dysfunction. In this review, we review constitution presynaptic vesicle related describe environmental evidence dysfunction increase risky possibility concerning intracellular transmission their functional outcomes. We summarize alterations synaptic vesicular involvement some highly vulnerable generalize different potential targets therapeutic strategies pathogenic mechanisms, providing reference further studies treatment future. But it remains researched on recently discovered converging mechanism dynamics PD, will provide more profound put up new tactics patients.

Язык: Английский

Association of glyphosate exposure with multiple adverse outcomes and potential mediators DOI
Wenxiang Li, Daizai Lei, Guangyi Huang

и другие.

Chemosphere, Год журнала: 2023, Номер 345, С. 140477 - 140477

Опубликована: Окт. 17, 2023

Язык: Английский

Процитировано

11
Precision of in Vivo Pesticide Toxicology Research Can Be Promoted by Mass Spectrometry Imaging Technology DOI

Yunping Wang,

L. C. Wang,

Liping Luo

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 30, 2025

Pesticides are crucial for agricultural production, but their excessive use has become a significant pollution source, leading to increased pesticide residues in the environment and food posing threat human health. In vivo toxicology research aims protect humans with detection technology playing key role. Spatial information plays role toxicity research. However, current technologies cannot simultaneously analyze content spatial on pesticides vivo. Mass spectrometry imaging (MSI) can address this limitation by analyzing distribution of chemicals high sensitivity efficiency, aiding discovery toxic biomarkers mechanisms. Nevertheless, limited application MSI hinders accuracy such Therefore, should be promoted enhance

Язык: Английский

Процитировано

0
A triple-mode strategy for ultrasensitive and accurate point-of-care detection of glyphosate based on the carved bimetallic prussian blue nanozyme and gold polyhedra DOI
Yi He,

Runzi Zhang,

Shunbi Xie

и другие.

Journal of Food Composition and Analysis, Год журнала: 2025, Номер 144, С. 107661 - 107661

Опубликована: Апрель 23, 2025

Язык: Английский

Процитировано

0
Association Between Urinary Glyphosate Exposure and Cognitive Impairment in Older Adults from NHANES 2013-2014 DOI

Jiawen Ren,

Yongquan Yu, Yucheng Wang

и другие.

Journal of Alzheimer s Disease, Год журнала: 2023, Номер 97(2), С. 609 - 620

Опубликована: Дек. 19, 2023

Glyphosate is the most commonly used herbicide with potential neurotoxicity. However, limited epidemical evidence found in relationship between glyphosate and cognitive impairment, especially cognitive-disrupting sensitive elderly populations.

Язык: Английский

Процитировано

7
Effects of glyphosate on neurotoxicity, oxidative stress and immune suppression in red swamp crayfish, Procambarus Clarkii DOI
Yi Huang, Qiang Huang,

Kelei Zhou

и другие.

Aquatic Toxicology, Год журнала: 2024, Номер 275, С. 107050 - 107050

Опубликована: Авг. 11, 2024

Язык: Английский

Процитировано

2
Reserpine, a novel N6-methyladenosine regulator, reverses Lenvatinib resistance in hepatocellular carcinoma DOI
Lei Zhao, Heyao Ma,

Yuhui Jiang

и другие.

Phytomedicine, Год журнала: 2024, Номер 135, С. 156002 - 156002

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

2
The herbicide glyphosate inhibits hippocampal long-term potentiation and learning through activation of pro-inflammatory signaling DOI Creative Commons
Yukitoshi Izumi,

Kazuko A. O’Dell,

Charles F. Zorumski

и другие.

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Окт. 21, 2023

Abstract Glyphosate, a herbicide marketed as Roundup, is widely used but there are concerns this exposure could impair cognitive function. In the CA1 region of rat hippocampal slices, we investigated whether glyphosate alters synaptic transmission and long-term potentiation (LTP), cellular model learning memory. Our hypothesis that neuronal function impairs LTP induction via activation pro-inflammatory processes. Roundup depressed excitatory potentials(EPSPs) in dose-dependent manner with complete suppression at 2000 mg/L. At concentrations ≤ 20 mg/L did not affect basal transmission, 4 administered for 30 min inhibited induction. Acute administration 10–100 μM also Minocycline, an inhibitor microglial activation, TAK-242, toll-like receptor (TLR4), both overcame inhibitory effects 100 µM glyphosate. Similarly, lipopolysaccharide from Rhodobacter sphaeroides (LPS-RS), different TLR4 antagonist, effects. addition, ISRIB (integrated stress response inhibitor) quercetin, endoplasmic reticulum stress, We observed vivo injection (16.9 mg/kg i.p.) impaired one-trial avoidance learning. This deficit was overcome by TAK-242. These observations indicate can through signaling microglia.

Язык: Английский

Процитировано

6
Glyphosate as a direct or indirect activator of pro-inflammatory signaling and cognitive impairment DOI Creative Commons
Yukitoshi Izumi,

Kazuko A. O’Dell,

Charles F. Zorumski

и другие.

Neural Regeneration Research, Год журнала: 2023, Номер 19(10), С. 2212 - 2218

Опубликована: Дек. 21, 2023

Glyphosate-based herbicides are widely used around the world, making it likely that most humans have significant exposure. Because of habitual exposure, there concerns about toxicity including neurotoxicity could result in neurological, psychiatric, or cognitive impairment. We recently found a single injection glyphosate inhibits long-term potentiation, cellular model learning and memory, rat hippocampal slices dissected 1 day after injection, indicating glyphosate-based can alter function. adversely affect function either indirectly and/or directly. Indirectly, gut microbiota, if dysbiosis results endotoxemia (leaky gut), infiltrated bacterial by-products such as lipopolysaccharides activate pro-inflammatory cascades. Glyphosate also directly trigger Indeed, we observed acute exposure potentiation slices. Interestingly, direct inhibition by appears to be similar lipopolysaccharides. There several possible measures control neuroinflammation caused glyphosate. Dietary intake polyphenols, quercetin, which overcome inhibitory effect on one effective strategy. The aim this narrative review is discuss mechanisms underlying following means identify potential treatments.

Язык: Английский

Процитировано

4
Multifunctional effects of nitrification and urease inhibitors: Decreasing soil herbicide residues and reducing nitrous oxide emissions simultaneously DOI Creative Commons
Yaohui Liu, Weijin Wang, Manyun Zhang

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 287, С. 117301 - 117301

Опубликована: Ноя. 1, 2024

Glyphosate pollution and greenhouse gas emissions are major problem in achieving sustainable soil management. It is necessary to develop effective strategies simultaneously reduce herbicide residues nitrous oxide (N

Язык: Английский

Процитировано

1
Role of voltage-dependent calcium channels on the striatal in vivo dopamine release induced by the organophosphorus pesticide glyphosate DOI Creative Commons
Carmen Costas‐Ferreira,

Ana Carolina de Jesus Silva,

Lorane Izabel da Silva Hage-Melim

и другие.

Environmental Toxicology and Pharmacology, Год журнала: 2023, Номер 104, С. 104285 - 104285

Опубликована: Сен. 30, 2023

In the present study, we investigated role of voltage-sensitive calcium channels (VSCCs) on striatal dopamine release induced by pesticide glyphosate (GLY) using selective VSCC inhibitors. The levels were measured in vivo cerebral microdialysis coupled to HPLC-ED. Nicardipine (L-type antagonist) or ω-conotoxin MVIIC (non-selective P/Q-type had no effect 5 mM GLY. contrast, flunarizine (T-type GVIA (neuronal N-type significantly reduced GLY-stimulated release. These results suggest that GLY-induced depends extracellular and its influx through T- VSCCs. findings corroborated molecular docking, which allowed us establish a correlation between GLY blocked with observed We propose new targets dorsal striatum, could have important implications for assessment risks non-target organisms.

Язык: Английский

Процитировано

2