Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 30, 2024
Rheumatoid
arthritis
(RA)
and
postmenopausal
osteoporosis
(PMOP)
are
common
bone-immune
diseases.
The
imbalance
between
helper
(Th17)
regulatory
T
cells
(Tregs)
produced
during
differentiation
of
CD4
+
plays
a
key
role
in
bone
remodelling
disorders
RA
PMOP.
However,
the
specific
mechanism
this
PMOP
has
not
been
clarified.
Identifying
underlying
Th17/Treg
represents
factor
research
development
new
drugs
for
immune
In
review,
potential
roles
Th17,
Treg,
regulating
have
summarised,
mechanisms
by
which
probiotics,
traditional
Chinese
medicine
compounds,
monomers
maintain
balance
expounded.
maintenance
could
be
considered
as
an
therapeutic
alternative
treatment
This
study
also
summarizes
advantages
disadvantages
conventional
treatments
quality
life
rehabilitation
patients
with
findings
presented
her
will
provide
better
understanding
close
relationship
immunity
chronic
diseases
ideas
future
research,
prevention,
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Июнь 30, 2023
Abstract
Amyloid
β
protein
(Aβ)
is
the
main
component
of
neuritic
plaques
in
Alzheimer’s
disease
(AD),
and
its
accumulation
has
been
considered
as
molecular
driver
pathogenesis
progression.
Aβ
prime
target
for
development
AD
therapy.
However,
repeated
failures
Aβ-targeted
clinical
trials
have
cast
considerable
doubt
on
amyloid
cascade
hypothesis
whether
drug
followed
correct
course.
recent
successes
targeted
assuaged
those
doubts.
In
this
review,
we
discussed
evolution
over
last
30
years
summarized
application
diagnosis
modification.
particular,
extensively
pitfalls,
promises
important
unanswered
questions
regarding
current
anti-Aβ
therapy,
well
strategies
further
study
more
feasible
approaches
optimization
prevention
treatment.
Acta Pharmaceutica Sinica B,
Год журнала:
2021,
Номер
11(11), С. 3337 - 3363
Опубликована: Сен. 20, 2021
COVID-19
pandemic
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
has
spread
across
the
globe,
posing
an
enormous
threat
to
public
health
and
safety.
Traditional
Chinese
medicine
(TCM),
in
combination
with
Western
(WM),
made
important
lasting
contributions
battle
against
COVID-19.
In
this
review,
updated
clinical
effects
potential
mechanisms
of
TCM,
presented
newly
recognized
three
distinct
phases
disease,
are
summarized
discussed.
By
integrating
available
preclinical
evidence,
efficacies
underlying
TCM
on
COVID-19,
including
highly
recommended
patent
medicines
formulas,
described
a
panorama.
We
hope
that
comprehensive
review
not
only
provides
reference
for
care
professionals
recognize
significant
but
also
serves
as
evidence-based
in-depth
summary
analysis
facilitate
understanding
true
scientific
value
TCM.
Proceedings of the National Academy of Sciences,
Год журнала:
2023,
Номер
120(18)
Опубликована: Апрель 24, 2023
The
coronavirus
disease
2019
(COVID-19)
pandemic
is
an
ongoing
global
health
concern,
and
effective
antiviral
reagents
are
urgently
needed.
Traditional
Chinese
medicine
theory-driven
natural
drug
research
development
(TCMT-NDRD)
a
feasible
method
to
address
this
issue
as
the
traditional
formulae
have
been
shown
in
treatment
of
COVID-19.
Huashi
Baidu
decoction
(Q-14)
clinically
approved
formula
for
COVID-19
therapy
with
anti-inflammatory
effects.
Here,
integrative
pharmacological
strategy
was
applied
identify
bioactive
compounds
from
Q-14.
Overall,
total
343
chemical
were
initially
characterized,
60
prototype
Q-14
subsequently
traced
plasma
using
ultrahigh-performance
liquid
chromatography
quadrupole
time-of-flight
mass
spectrometry.
Among
compounds,
six
(magnolol,
glycyrrhisoflavone,
licoisoflavone
A,
emodin,
echinatin,
quercetin)
identified
showing
dose-dependent
inhibition
effect
on
SARS-CoV-2
infection,
including
two
inhibitors
(echinatin
main
protease
(Mpro),
well
(glycyrrhisoflavone
A)
RNA-dependent
RNA
polymerase
(RdRp).
Meanwhile,
three
components,
licochalcone
B,
SARS-CoV-2-infected
inflammatory
cell
model.
In
addition,
glycyrrhisoflavone
A
also
displayed
strong
inhibitory
activities
against
cAMP-specific
3',5'-cyclic
phosphodiesterase
4
(PDE4).
Crystal
structures
PDE4
complex
or
determined
at
resolutions
1.54
Å
1.65
Å,
respectively,
both
bind
active
site
similar
interactions.
These
findings
will
greatly
stimulate
study
TCMT-NDRD
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 2943 - 2943
Опубликована: Фев. 2, 2023
As
an
emerging
sequencing
technology,
single-cell
RNA
(scRNA-Seq)
has
become
a
powerful
tool
for
describing
cell
subpopulation
classification
and
heterogeneity
by
achieving
high-throughput
multidimensional
analysis
of
individual
cells
circumventing
the
shortcomings
traditional
detecting
average
transcript
level
populations.
It
been
applied
to
life
science
medicine
research
fields
such
as
tracking
dynamic
differentiation,
revealing
sensitive
effector
cells,
key
molecular
events
diseases.
This
review
focuses
on
recent
technological
innovations
in
scRNA-Seq,
highlighting
latest
results
with
scRNA-Seq
core
technology
frontier
areas
embryology,
histology,
oncology,
immunology.
In
addition,
this
outlines
prospects
its
innovative
application
Chinese
(TCM)
discusses
issues
currently
being
addressed
great
potential
exploring
disease
diagnostic
targets
uncovering
drug
therapeutic
combination
multiomics
technologies.
Abstract
Network
pharmacology
can
ascertain
the
therapeutic
mechanism
of
drugs
for
treating
diseases
at
level
biological
targets
and
pathways.
The
effective
study
traditional
Chinese
medicine
(TCM)
characterized
by
multi-component,
multi-targeted,
integrative
efficacy,
perfectly
corresponds
to
application
network
pharmacology.
Currently,
has
been
widely
utilized
clarify
physiological
activity
TCM.
In
this
review,
we
comprehensively
summarize
in
TCM
reveal
its
potential
verifying
phenotype
underlying
causes
diseases,
realizing
personalized
accurate
We
searched
literature
using
“TCM
pharmacology”
“network
as
keywords
from
Web
Science,
PubMed,
Google
Scholar,
well
National
Knowledge
Infrastructure
last
decade.
origins,
development,
are
closely
correlated
with
which
applied
China
thousands
years.
have
same
core
idea
promote
each
other.
A
well-defined
research
strategy
several
aspects
research,
including
elucidation
basis
syndromes,
prediction
targets,
screening
active
compounds,
decipherment
mechanisms
diseases.
However,
factors
limit
application,
such
selection
databases
algorithms,
unstable
quality
results,
lack
standardization.
This
review
aims
provide
references
ideas
encourage
precise
use
medicine.
