Cell Death Discovery,
Год журнала:
2023,
Номер
9(1)
Опубликована: Июль 6, 2023
Lipid
droplets
(LDs)
are
the
organelles
for
storing
neutral
lipids,
which
broken
down
when
energy
is
insufficient.
It
has
been
suggested
that
excessive
accumulation
of
LDs
can
affect
cellular
function,
important
to
coordinate
homeostasis
lipids
in
vivo.
Lysosomes
play
an
role
degradation
and
process
selective
autophagy
through
lysosomes
known
as
lipophagy.
Dysregulation
lipid
metabolism
recently
associated
with
a
variety
central
nervous
system
(CNS)
diseases,
but
specific
regulatory
mechanisms
lipophagy
these
diseases
remain
be
elucidated.
This
review
summarizes
various
forms
discusses
plays
development
CNS
order
reveal
related
potential
therapeutic
targets
diseases.
Neuroscience Bulletin,
Год журнала:
2022,
Номер
38(10), С. 1229 - 1247
Опубликована: Май 5, 2022
Abstract
Ischemic
stroke
caused
by
intracranial
vascular
occlusion
has
become
increasingly
prevalent
with
considerable
mortality
and
disability,
which
gravely
burdens
the
global
economy.
Current
relatively
effective
clinical
treatments
are
limited
to
intravenous
alteplase
thrombectomy.
Even
so,
patients
still
benefit
little
due
short
therapeutic
window
risk
of
ischemia/reperfusion
injury.
It
is
therefore
urgent
figure
out
neuronal
death
mechanisms
following
ischemic
in
order
develop
new
neuroprotective
strategies.
Regarding
pathogenesis,
multiple
pathological
events
trigger
activation
cell
pathways.
Particular
attention
should
be
devoted
excitotoxicity,
oxidative
stress,
inflammatory
responses.
Thus,
this
article,
we
first
review
principal
underlying
mediated
these
significant
events,
such
as
intrinsic
extrinsic
apoptosis,
ferroptosis,
parthanatos,
pyroptosis,
necroptosis,
autophagic
death.
Then,
further
discuss
possibility
interventions
targeting
summarize
present
pharmacological
achievements.
Cell Death and Disease,
Год журнала:
2022,
Номер
13(8)
Опубликована: Авг. 15, 2022
Abstract
Alzheimer’s
disease
(AD)
is
a
devastating
neurodegenerative
disorder
characterized
by
gradual
loss
of
memory
and
cognitive
function,
which
constitutes
heavy
burden
on
the
healthcare
system
globally.
Current
therapeutics
to
interfere
with
underlying
process
in
AD
still
under
development.
Although
many
efforts
have
centered
toxic
forms
Aβ
effectively
tackle
AD,
considering
unsatisfactory
results
so
far
it
vital
examine
other
targets
therapeutic
approaches
as
well.
The
endoplasmic
reticulum
(ER)
stress
refers
build-up
unfolded
or
misfolded
proteins
within
ER,
thus,
perturbing
ER
cellular
homeostasis.
Emerging
evidence
indicates
that
contributes
onset
development
AD.
A
thorough
elucidation
machinery
pathology
may
help
open
up
new
avenues
management
this
condition
relieve
dementia
symptoms.
Herein,
we
aim
at
deciphering
unique
role
pathogenesis,
reviewing
key
findings,
existing
controversy
an
attempt
summarize
plausible
interventions
pathophysiology.
Autophagy,
Год журнала:
2023,
Номер
20(1), С. 4 - 14
Опубликована: Авг. 18, 2023
Macroautophagy/autophagy,
is
widely
recognized
for
its
crucial
role
in
enabling
cell
survival
and
maintaining
cellular
energy
homeostasis
during
starvation
or
stress.
Its
regulation
intricately
linked
to
status.
In
this
review,
covering
yeast,
mammals,
plants,
we
aim
provide
a
comprehensive
overview
of
the
understanding
roles
mechanisms
carbon-
glucose-deprivation
related
autophagy,
showing
how
cells
effectively
respond
such
challenges
survival.
Further
investigation
needed
determine
specific
degraded
substrates
by
autophagy
glucose
deprivation
diverse
varying
durations
starvation.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
162, С. 114671 - 114671
Опубликована: Апрель 8, 2023
Stroke
is
one
of
the
leading
causes
death
and
long-term
disability
worldwide.
More
than
80
%
strokes
are
ischemic,
caused
by
an
occlusion
cerebral
arteries.
Without
question,
restoration
blood
supply
as
soon
possible
first
therapeutic
strategy.
Nonetheless
paradoxically,
reperfusion
can
further
aggravate
injury
through
a
series
reactions
known
ischemia-reperfusion
(CIRI).
Mitochondria
play
vital
role
in
promoting
nerve
survival
neurological
function
recovery
mitochondrial
dysfunction
considered
characteristics
CIRI.
Neurons
often
die
due
to
oxidative
stress
imbalance
energy
metabolism
following
CIRI,
there
strong
association
with
dysfunction.
Altered
dynamics
reaction
stress.
Mitochondrial
refers
maintenance
integrity,
distribution,
size
mitochondria
well
their
ability
resist
external
stimuli
continuous
cycle
fission
fusion.
Therefore,
improving
means
treating
This
review
discusses
relationship
between
CIRI
emphasizes
potential
approach
improve
prognosis
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Окт. 14, 2024
Iron,
an
essential
mineral
in
the
body,
is
involved
numerous
physiological
processes,
making
maintenance
of
iron
homeostasis
crucial
for
overall
health.
Both
overload
and
deficiency
can
cause
various
disorders
human
diseases.
Ferroptosis,
a
form
cell
death
dependent
on
iron,
characterized
by
extensive
peroxidation
lipids.
Unlike
other
kinds
classical
unprogrammed
death,
ferroptosis
primarily
linked
to
disruptions
metabolism,
lipid
peroxidation,
antioxidant
system
imbalance.
Ferroptosis
regulated
through
transcription,
translation,
post-translational
modifications,
which
affect
cellular
sensitivity
ferroptosis.
Over
past
decade
or
so,
diseases
have
been
as
part
their
etiology,
including
cancers,
metabolic
disorders,
autoimmune
diseases,
central
nervous
cardiovascular
musculoskeletal
Ferroptosis-related
proteins
become
attractive
targets
many
major
that
are
currently
incurable,
some
regulators
shown
therapeutic
effects
clinical
trials
although
further
validation
potential
needed.
Therefore,
in-depth
analysis
its
molecular
mechanisms
may
offer
additional
strategies
prevention
treatment.
In
this
review,
we
discuss
significance
contribution
etiology
development
along
with
evidence
supporting
targeting
approach.
Importantly,
evaluate
recent
promising
interventions,
providing
guidance
future
targeted
treatment
therapies
against
ACS Nano,
Год журнала:
2024,
Номер
18(4), С. 3733 - 3751
Опубликована: Янв. 22, 2024
Nanoplastics
(NPs),
as
emerging
pollutants,
have
attracted
global
attention.
Nevertheless,
the
adverse
effects
of
NPs
on
female
reproductive
health,
especially
unexplained
miscarriage,
are
poorly
understood.
Defects
trophoblast
cell
migration
and
invasion
associated
with
miscarriage.
Migrasomes
were
identified
cellular
organelles
largely
unidentified
functions.
Whether
might
affect
migration,
invasion,
migrasome
formation
induce
miscarriage
has
been
completely
unexplored.
In
this
study,
we
selected
polystyrene
nanoplastics
(PS-NPs,
50
nm)
a
model
plastic
particles
treated
human
cells
pregnant
mice
PS-NPs
at
doses
near
actual
environmental
exposure
in
humans.
We
found
that
to
induced
mouse
suppressed
ROCK1-mediated
migration/invasion
formation.
SOX2
was
transcription
factor
ROCK1.
activated
autophagy
promoted
degradation
SOX2,
thus
suppressing
SOX2-mediated
ROCK1
transcription.
Supplementing
murine
or
could
efficiently
rescue
alleviate
Analysis
protein
levels
ROCK1,
TSPAN4,
NDST1,
P62,
LC-3BII/I
PS-NP-exposed
cells,
villous
tissues
patients,
placental
gave
consistent
results.
Collectively,
study
revealed
toxicity
their
potential
regulatory
mechanism,
indicating
NP
is
risk
for
health.
Frontiers in Aging Neuroscience,
Год журнала:
2021,
Номер
13
Опубликована: Июнь 8, 2021
Ischemic
stroke
is
a
severe
cerebrovascular
disease
with
high
mortality
and
morbidity.
In
recent
years,
reperfusion
treatments
based
on
thrombolytic
thrombectomy
are
major
managements
for
ischemic
patients,
the
recanalization
time
window
has
been
extended
to
over
24
h.
However,
extension
of
window,
risk
ischemia/reperfusion
(I/R)
injury
following
therapy
becomes
big
challenge
patient
outcomes.
I/R
leads
neuronal
death
due
imbalance
in
metabolic
supply
demand,
which
usually
related
mitochondrial
dysfunction.
Mitophagy
type
selective
autophagy
referring
process
specific
autophagic
elimination
damaged
or
dysfunctional
mitochondria
prevent
generation
excessive
reactive
oxygen
species
(ROS)
subsequent
cell
death.
Recent
advances
have
implicated
protective
role
mitophagy
cerebral
ischemia
mainly
associated
its
neuroprotective
effects
injury.
This
review
discusses
involvement
dynamics
pathophysiology
particular,
focusing
therapeutic
potential
regulation
possibility
using
mitophagy-related
interventions
as
an
adjunctive
approach
after
stroke.
