Journal of environmental chemical engineering, Год журнала: 2024, Номер 12(5), С. 114094 - 114094
Опубликована: Сен. 12, 2024
Язык: Английский
Journal of environmental chemical engineering, Год журнала: 2024, Номер 12(3), С. 112926 - 112926
Опубликована: Май 4, 2024
Язык: Английский
Процитировано
22
Journal of Hazardous Materials, Год журнала: 2025, Номер 487, С. 137091 - 137091
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
1
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Undifferentiated spermatogonia (Undiff-SPG) plays a critical role in maintaining continual spermatogenesis. However, the toxic effects and molecular mechanisms of maternal exposure to nanoplastics on offspring Undiff-SPG remain elusive. Here, we utilized multiomics combined cytomorphological approach explore reproductive toxicity polystyrene (PS-NPs) mice after exposure. The results indicated that PS-NPs decreased testosterone levels reduced sperm concentration quality male through Moreover, could enter Undiff-SPG, increase ROS levels, decrease viability Undiff-SPG. According transcriptomics proteomics analyses, caused inflammation by increasing expression Tnfsf18/Nlrp6. Mechanistically, found induced overexpression transcription factor Prdm14 which suppressed Ccdc33 Tcirg1. Additionally, disrupted spermatogenesis inhibiting Osbp2/Zcwpw1/Dhps expression. Furthermore, autophagic flux reducing Igbp1/Gabarapl2. In conclusion, resulted disrupt normal autophagy.
Язык: Английский
Процитировано
1
Communications Biology, Год журнала: 2025, Номер 8(1)
Опубликована: Янв. 20, 2025
Almost all high-grade gliomas, particularly glioblastoma (GBM), are highly migratory and aggressive. Migrasomes organelles produced by cells capable of mediating intercellular communication. Thus, GBM may produce migrasomes during migration. However, it remains unclear whether can influence migration invasion. In this study, we observed the presence formation in cells. We found that expression levels key migrasome factor, tetraspanin 4 (TSPAN4), correlated positively with pathological grade poor prognosis based on databases clinical samples analysis. Subsequently, knocked down TSPAN4 cell invasion were significantly inhibited due to reduced migrasomes. further confirmed enriched extracellular matrix (ECM)-related proteins such as p21-activating kinase (PAK4) laminin alpha (LAMA4). Our experimental results suggest promote releasing into space. Overall, identified molecular mechanisms which they regulate them, providing potential targets for treating GBM. Observation (GBM) analysis migrasome-enriched revealed matrix-associated PAK4 LAMA4.
Язык: Английский
Процитировано
1
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Янв. 30, 2025
The neurological implications of micro- and nanoplastic exposure have recently come under scrutiny due to the environmental prevalence these synthetic materials. Parkinson's disease (PD) is a major disorder clinically characterized by intracellular Lewy-body inclusions dopaminergic neuronal death. These pathological hallmarks PD, according Braak's hypothesis, are mediated afferent propagation α synuclein (αS) via enteric nervous system, or so-called gut-brain axis. Here we first examined effect polystyrene nanoplastics on peripheral central pathogenesis A53T, representative αS mutant. Specifically, accelerated amyloid aggregation A53T αS, which subsequently elevated in vitro production glial activation biomarkers, cytokines, reactive oxygen species compromised mitochondrial lysosomal membrane integrity, further shifting cellular metabolite profiles association with PD pathophysiology. In vivo, coadministration facilitated their synergistic gut-to-brain transmission mice, leading progressive impairment physical motor skills resemblance characteristic symptoms. This study provides insights into response vulnerability axis nanoplastics.
Язык: Английский
Процитировано
1
Environmental Pollution, Год журнала: 2024, Номер 359, С. 124742 - 124742
Опубликована: Авг. 15, 2024
Язык: Английский
Процитировано
7
Particle and Fibre Toxicology, Год журнала: 2024, Номер 21(1)
Опубликована: Сен. 11, 2024
Язык: Английский
Процитировано
7
Reproductive Biology and Endocrinology, Год журнала: 2024, Номер 22(1)
Опубликована: Ноя. 11, 2024
The female reproductive system can face serious disorders and show abnormalities under the influence of environmental pollutants. Microplastics (MPs) nanoplastics (NPs) as emerging pollutants, by affecting different components this system, may make fertility a challenge. Animal studies have demonstrated that exposure to these substances weakens function ovaries causes decrease in ovarian reserve capacity. Also, continuous micro/nano plastics (MNPs) leads increased levels reactive oxygen species, induction oxidative stress, inflammatory responses, apoptosis granulosa cells, reduction number follicles. Furthermore, interfering with hypothalamic-pituitary-ovarian axis, particles disturb normal androgens endocrine balance delay growth gonads. Exposure MNPs accelerate carcinogenesis humans animal models. determined accumulate placenta, causing metabolic changes, disrupting development fetus, endangering health future generations. In humans, presence micro/nanoplastics placenta tissue, infant feces, breast milk has been reported. These directly affect mother increasing risk premature birth other pregnancy complications. This review aims outline hazardous effects on fetal discuss results experiments human research focusing cellular molecular pathways.
Язык: Английский
Процитировано
5
Journal of Reproductive Immunology, Год журнала: 2025, Номер 168, С. 104441 - 104441
Опубликована: Янв. 21, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 302, С. 140531 - 140531
Опубликована: Янв. 30, 2025
Язык: Английский
Процитировано
0