Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Май 16, 2023
Introduction:
Tanshinone
IIA
(Tan
IIA),
the
major
active
lipophilic
ingredient
of
Radix
Salviae
Miltiorrhizae,
exerts
various
therapeutic
effects
on
cardiovascular
system.
We
aimed
to
identify
preclinical
evidence
and
possible
mechanisms
Tan
as
a
cardioprotective
agent
in
treatment
myocardial
ischemia/reperfusion
injury.
Methods:
The
study
quality
scores
twenty-eight
eligible
studies
data
analyses
were
separately
assessed
using
CAMARADES
10-item
checklist
Rev-Man
5.3
software.
Results:
score
ranged
from
3/10
7/10
points.
present
provided
preliminary
that
could
significantly
decrease
infarct
size,
cardiac
enzyme
activity
troponin
levels
compared
with
those
control
group
(p
<
0.05).
Discussion:
alleviated
I/R
injury
via
antioxidant,
anti-inflammatory,
anti-apoptosis
improved
circulation
energy
metabolism.
Thus,
is
promising
for
should
be
further
investigated
clinical
trials.
Myocardial
infarction
(MI)
is
strongly
associated
with
the
temporal
regulation
of
cardiac
immunity.
However,
a
variety
current
clinical
trials
have
failed
because
lack
post-MI
immunomodulating/anti-inflammatory
targets.
Single-cell
RNA
sequencing
analysis
Cd45+
immune
cell
at
0,
3,
7,
and
14
d
after
injury
in
mouse
left
anterior
descending
coronary
artery
ligation
model
performed.
Major
populations,
distinct
subsets,
dynamic
changes
are
identified.
Macrophages
(Mø)
most
abundant,
peaking
3
infarction.
Mø-5
Mø-6
predominant
infiltrated
subsets
this
time
point,
strong
expression
inflammatory
factors.
Further
demonstrates
that
suppressing
these
sets
attenuated
pathological
MI
progression
by
preventing
subsequent
leukocyte
extravasation
adverse
remodeling.
Abundant
apoptotic
neutrophils
profibrotic
macrophage
subset
on
days
7
14,
respectively,
also
detected.
These
results
provide
basis
for
developing
type-
time-specific
interventions
MI.
Biochemical and Biophysical Research Communications,
Год журнала:
2021,
Номер
575, С. 1 - 7
Опубликована: Авг. 24, 2021
The
pathogenesis
of
atherosclerosis
is
closely
related
to
endothelial
cell
injury
caused
by
lipid
peroxidation-induced
ferroptosis.
Tanshinone
IIA
(TSA)
protects
tissues
from
damage.
In
this
study,
we
investigated
whether
TSA
exerts
its
protective
effect
on
cells
inhibiting
Ferroptosis
was
induced
in
human
coronary
artery
(HCAECs),
and
were
treated
with
TSA.
Morphological
examination
indicated
that
exerted
a
significant
the
HCAECs.
This
further
confirmed
LDH
release
death
detection
assays.
Flow
cytometry
revealed
significantly
reduced
excessive
accumulation
total
cellular
ROS
ferroptosis
inducers.
also
restored
reduction
glutathione
(GSH),
potent
abundant
reductant
cells.
addition,
found
promoted
expression
NRF2,
an
essential
player
response
oxidative
stress,
downstream
genes.
Immunofluorescent
staining
nuclear
translocation
NRF2.
Increased
NRF2
validated
Western
blot
evaluation
cytoplasmic
protein
extracts.
Furthermore,
inhibition
abolished
effects
These
data
demonstrate
represses
via
activation
Plants,
Год журнала:
2023,
Номер
12(15), С. 2845 - 2845
Опубликована: Авг. 1, 2023
Euphorbia
ebracteolata
Hayata
(Euphorbiaceae
family)
is
a
perennial
plant
that
widely
distributed
in
Korea,
Japan,
and
China.
Its
roots
contain
bioactive
diterpenes
have
anti-inflammatory
properties.
However,
the
mechanisms
are
not
yet
fully
understood.
This
study
aimed
to
identify
most
active
compound
from
of
E.
Hayata,
using
bioassay-guided
fractionation
combinative
method
high-speed
countercurrent
chromatography
(HSCCC)
preparative
high-performance
liquid
(HPLC).
Then,
we
investigated
its
mechanism
lipopolysaccharide
(LPS)-stimulated
RAW
264.7
macrophages.
Ebractenoid
F
was
identified
as
potent
Hayata.
significantly
decreased
nitric
oxide
(NO)
production
nuclear
factor-κB
(NF-κB)
activation
induced
by
LPS
Moreover,
ebractenoid
degradation
inhibitory
κB-α,
translocation
p65
p50
subunits
NF-κB,
expression
NF-κB
downstream
genes.
Furthermore,
inhibited
phosphorylation
Akt
mitogen-activated
protein
kinases
(MAPKs),
such
extracellular
signal-regulated
kinase
(ERK)
c-Jun
NH2
terminal
(JNK),
LPS-stimulated
cells.
In
conclusion,
exerts
effect
suppressing
NF-κB-mediated
NO
may
be
useful
therapeutic
for
prevention
or
treatment
inflammation-associated
diseases.
The
blood
flow,
when
restored
clinically
following
a
myocardial
infarction
(MI),
disrupts
the
physiological
and
metabolic
equilibrium
of
ischemic
area,
resulting
in
secondary
damage
termed
ischemia-reperfusion
injury
(MIRI).
Reactive
oxygen
species
(ROS)
generation
inflammatory
reactions
stand
as
primary
culprits
behind
MIRI.
Current
strategies
focusing
on
ROS-scavenging
anti-inflammatory
actions
have
limited
remission
Prussian
blue
nanozyme
(PBNz)
exhibits
multiple
enzyme-like
activities
including
catalase
(CAT),
peroxidase
(POD),
superoxide
dismutase
(SOD),
which
are
beneficial
for
ROS
clearance
fighting
inflammation.
Herein,
formulation
PBNz
coated
with
polydextrose-sorbitol
carboxymethyl
ether
(PBNz@PSC)
was
developed
to
enhance
its
efficacy,
biocompatibility,
safety
treatment
PBNz@PSC
not
only
showed
enhanced
SOD-like
activity
due
polysaccharide
attributes
but
also
could
passively
target
damaged
myocardium
through
permeability
retention
(EPR)
effect.
Both
vitro
vivo
studies
validated
their
excellent
safety,
ability,
capacity
drive
macrophage
polarization
from
M1
toward
M2,
thereby
diminishing
levels
IL-1β,
IL-6,
TNF-α
combat
Consequently,
can
reverse
ischemia
reperfusion-induced
injury,
reduce
coronary
microvascular
obstruction
(MVO),
improve
remodeling
cardiac
function.
Moreover,
more
pronounced
therapeutic
effects
MIRI
than
clinical
drug,
sulfotanshinone
IIA
sodium.
Notably,
our
findings
revealed
possible
mechanism
treating
MIRI,
mediated
AMPK
activation.
In
conclusion,
this
study
presents
pioneering
strategy
addressing
promising
improved
outcomes.
Cancer and Metastasis Reviews,
Год журнала:
2021,
Номер
40(3), С. 691 - 720
Опубликована: Авг. 28, 2021
The
ever-growing
perception
of
cancer
stem
cells
(CSCs)
as
a
plastic
state
rather
than
hardwired
defined
entity
has
evolved
our
understanding
the
functional
and
biological
plasticity
these
elusive
components
in
malignancies.
Pancreatic
(PC),
based
on
its
features
clinical
evolution,
is
prototypical
example
CSC-driven
disease.
Since
discovery
pancreatic
CSCs
(PCSCs)
2007,
evidence
unraveled
their
control
over
many
facets
natural
history
PC,
including
primary
tumor
growth,
metastatic
progression,
disease
recurrence,
acquired
drug
resistance.
Consequently,
current
near-ubiquitous
treatment
regimens
for
PC
using
aggressive
cytotoxic
agents,
aimed
at
''tumor
debulking''
eradication
CSCs,
have
proven
ineffective
providing
clinically
convincing
improvements
patients
with
this
dreadful
Herein,
we
review
key
hallmarks
well
intrinsic
extrinsic
resistance
mechanisms
that
mediate
failure
enlist
potential
CSC-targeting
'natural
agents'
are
gaining
popularity
recent
years.
A
better
molecular
landscape
PCSC-intrinsic
evasion
chemotherapeutic
drugs
offers
facile
opportunity
treating
an
intractable
grim
prognosis
dire
need
effective
therapeutic
advances.
Critical Reviews in Plant Sciences,
Год журнала:
2021,
Номер
40(3), С. 243 - 283
Опубликована: Май 4, 2021
Salvia
miltiorrhiza
is
one
of
the
most
well
known
species
in
genus
Lamiaceae
with
great
economic,
academic
and
medicinal
value.
It
was
recorded
as
a
traditional
Chinese
medicine
material
first
about
second
century
BC
later
many
other
ancient
books.
can
be
clinically
used
alone
or
mixed
herbs
to
treat
heart
cardiovascular
diseases
beneficial
for
management
diseases.
In
last
30
years,
S.
has
been
studied
intensively
model
system
plant
biology.
With
available
whole
genome
sequence
four
lines
large
number
transcriptome,
sRNAome
metabolome
data,
progresses
have
made
biosynthesis
regulatory
mechanisms
bioactive
compounds,
such
tanshinones,
phenolic
acids,
flavonoids,
prenylquinones.
this
review,
recent
results
biosynthetic
pathways
compounds
were
summarized.
The
effects
biotic
abtiotic
factors,
hormones,
transcription
factors
noncoding
RNAs
on
compound
overviewed.
mechanism
cross-talk
coordination
among
different
progress
metabolic
engineering
synthetic
biology
various
are
also
reviewed
discussed.
Phytotherapy Research,
Год журнала:
2023,
Номер
37(8), С. 3543 - 3558
Опубликована: Май 1, 2023
Abstract
Diabetic
cardiomyopathy
(DCM)
is
a
common
complication
in
patients
with
diabetes,
and
ultimately
leads
to
heart
failure.
Endoplasmic
reticulum
stress
(ERS)
induced
by
abnormal
glycolipid
metabolism
critical
factor
that
affects
the
occurrence
development
of
DCM.
Additionally,
upregulation/activation
silent
information
regulation
2
homolog‐1
(SIRT1)
has
been
shown
protect
against
Tanshinone
II
A
(Tan
IIA),
main
active
component
Salviae
miltiorrhizae
radix
et
rhizome
(a
valuable
Chinese
medicine),
protective
effects
cardiovascular
disease
diabetes.
However,
its
role
mechanisms
diabetes‐induced
cardiac
dysfunction
remain
unclear.
Therefore,
we
explored
whether
Tan
IIA
alleviates
ERS‐mediated
DCM
via
SIRT1
elucidated
underlying
mechanism.
The
results
suggested
alleviated
pathological
changes
hearts
diabetic
mice,
ameliorated
cytopathological
morphology
cardiomyocytes,
reduced
cell
death
rate,
inhibited
expression
ERS‐related
proteins
mRNA.
agonist
activities
glucose‐regulated
protein
78
(GRP78).
Furthermore,
opposite
under
inhibitor.
knockdown
was
siRNA‐SIRT1
transfection,
degree
GRP78
acetylation
increased.
Cumulatively,
inhibiting
ERS
upregulating
expression.