Molecular mechanistic pathways underlying the anticancer therapeutic efficiency of romidepsin

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114774 - 114774

Опубликована: Май 22, 2023

Romidepsin, also known as NSC630176, FR901228, FK-228, FR-901228, depsipeptide, or Istodax®, is a natural molecule produced by the Chromobacterium violaceum bacterium that has been approved for its anti-cancer effect. This compound selective histone deacetylase (HDAC) inhibitor, which modifies histones and epigenetic pathways. An imbalance between HDAC acetyltransferase can lead to down-regulation of regulatory genes, resulting in tumorigenesis. Inhibition HDACs romidepsin indirectly contributes anticancer therapeutic effect causing accumulation acetylated histones, restoring normal gene expression cancer cells, promoting alternative pathways, including immune response, p53/p21 signaling cascades, cleaved caspases, poly (ADP-ribose) polymerase (PARP), other events. Secondary pathways mediate action disrupting endoplasmic reticulum proteasome and/or aggresome, arresting cell cycle, inducing intrinsic extrinsic apoptosis, inhibiting angiogenesis, modifying tumor microenvironment. review aimed highlight specific molecular mechanisms responsible inhibition romidepsin. A more detailed understanding these significantly improve disorders pave way new approaches using targeted therapy.

Язык: Английский

---

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Янв. 22, 2024

The Vitamin D receptor (VDR) is a crucial nuclear that plays vital role in various physiological functions. To larger extent, the genomic effects of VDR maintain general wellbeing, and its modulation holds implications for multiple diseases. Current evidence regarding using vitamin or synthetic analogs to treat non-communicable diseases insufficient, though observational studies suggest potential benefits. Traditional Chinese medicines (TCMs) bioactive compounds derived from natural sources have garnered increasing attention. Interestingly, TCM formulae TCM-derived shown promise modulating activities. This review explores intriguing activity. We first emphasize latest information on genetic expression, function, structure VDR, providing comprehensive understanding this receptor. Following this, we several herbs known influence alongside mechanisms underpinning their action. Similarly, also discuss TCM-based target offering insights into roles modes

Язык: Английский

---

Tanshinone IIA induces ER stress and JNK activation to inhibit tumor growth and enhance anti-PD-1 immunotherapy in non-small cell lung cancer

Phytomedicine, Год журнала: 2024, Номер 128, С. 155431 - 155431

Опубликована: Фев. 7, 2024

Язык: Английский

---

Salvia miltiorrhiza Bunge (Danshen) based nano-delivery systems for anticancer therapeutics

Phytomedicine, Год журнала: 2024, Номер 128, С. 155521 - 155521

Опубликована: Март 8, 2024

Язык: Английский

---

Tanshinone IIA suppresses ferroptosis to attenuate renal podocyte injury in diabetic nephropathy through the embryonic lethal abnormal visual‐like protein 1 and acyl‐coenzyme A synthetase long‐chain family member 4 signaling pathway

Journal of Diabetes Investigation, Год журнала: 2024, Номер 15(8), С. 1003 - 1016

Опубликована: Апрель 22, 2024

Tanshinone IIA (TIIA) is one of the main components root red-rooted Salvia miltiorrhiza Bunge. However, molecular mechanisms underlying TIIA-mediated protective effects in diabetic nephropathy (DN) are still unclear.

Язык: Английский

---

Tanshinone IIA@β-cyclodextrin encapsulated with Eucommia ulmoides rubber/acetylated starch film as novel oral delivery system for therapy of orthotopic colon cancer

Carbohydrate Polymers, Год журнала: 2025, Номер 353, С. 123295 - 123295

Опубликована: Янв. 18, 2025

Язык: Английский

---

Prussian Blue Nanozyme Featuring Enhanced Superoxide Dismutase-like Activity for Myocardial Ischemia Reperfusion Injury Treatment

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

The blood flow, when restored clinically following a myocardial infarction (MI), disrupts the physiological and metabolic equilibrium of ischemic area, resulting in secondary damage termed ischemia-reperfusion injury (MIRI). Reactive oxygen species (ROS) generation inflammatory reactions stand as primary culprits behind MIRI. Current strategies focusing on ROS-scavenging anti-inflammatory actions have limited remission Prussian blue nanozyme (PBNz) exhibits multiple enzyme-like activities including catalase (CAT), peroxidase (POD), superoxide dismutase (SOD), which are beneficial for ROS clearance fighting inflammation. Herein, formulation PBNz coated with polydextrose-sorbitol carboxymethyl ether (PBNz@PSC) was developed to enhance its efficacy, biocompatibility, safety treatment PBNz@PSC not only showed enhanced SOD-like activity due polysaccharide attributes but also could passively target damaged myocardium through permeability retention (EPR) effect. Both vitro vivo studies validated their excellent safety, ability, capacity drive macrophage polarization from M1 toward M2, thereby diminishing levels IL-1β, IL-6, TNF-α combat Consequently, can reverse ischemia reperfusion-induced injury, reduce coronary microvascular obstruction (MVO), improve remodeling cardiac function. Moreover, more pronounced therapeutic effects MIRI than clinical drug, sulfotanshinone IIA sodium. Notably, our findings revealed possible mechanism treating MIRI, mediated AMPK activation. In conclusion, this study presents pioneering strategy addressing promising improved outcomes.

Язык: Английский

---

Tanshinone IIA mitigates postoperative cognitive dysfunction in aged rats by inhibiting hippocampal inflammation and ferroptosis: role of Nrf2/SLC7A11/GPX4 axis activation

NeuroToxicology, Год журнала: 2025, Номер 107, С. 62 - 73

Опубликована: Фев. 16, 2025

Язык: Английский

---

Inhibition of cell survival and invasion by Tanshinone IIA via FTH1: A key therapeutic target and biomarker in head and neck squamous cell carcinoma

Experimental and Therapeutic Medicine, Год журнала: 2022, Номер 24(2)

Опубликована: Июнь 16, 2022

Head and neck squamous cell carcinoma (HNSCC) is a worldwide public health problem; its incidence increasing it now the sixth most common cancer type worldwide. As indicated by existing studies, ferroptosis contributes to HNSCC progression Tanshinone IIA (TanIIA) may exert therapeutic effects via affecting ferroptosis. However, underlying mechanisms have remained be clarified. Therefore, main aim of present study was screen investigate key genes in regulating human hypopharynx line FaDu further elucidate mechanism action TanIIA. A list ferroptosis‑related obtained from FerrDb database. RNA‑sequencing expression (level 3) profiles corresponding clinical information (cases, n=502; normal controls, n=44) were downloaded The Cancer Genome Atlas dataset for (https://portal.gdc.com). limma package R software used differentially expressed mRNAs. Adjusted P<0.05 Log2(fold change) >1 or <‑1 defined as threshold differential ClusterProfiler (version 3.18.0) employed analyze Gene Ontology functional terms associated with potential targets perform Kyoto Encyclopedia Genes Genomes pathway analysis. ggplot2 draw boxplot pheatmap heatmap. DEG‑related protein‑protein interaction network built Search Tool Retrieval Interacting proteins database then visualization performed using Cytoscape. Ferritin heavy chain 1 (FTH1), transferrin (TF) TF receptor screened out Wayne diagram, which drawn Venn Diagram R. Kaplan‑Meier survival analysis log‑rank test compare differences between groups. receiver operating characteristic (v 0.4) (ROC) curve predictive accuracy FTH1 results verified Human Protein data. Immunohistochemistry immunofluorescence localize cells. Furthermore, Cell Counting Kit‑8 Transwell assays detect invasion ability, respectively. western blot protein expression. that three validated marker HNSCC, among significantly poorer survival. TanIIA demonstrated affect invasiveness markedly attenuate To conclude, gene highly inhibited partially suppressing FTH1.

Язык: Английский

---

Non-Coding RNAs in Tuberculosis Epidemiology: Platforms and Approaches for Investigating the Genome’s Dark Matter

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(8), С. 4430 - 4430

Опубликована: Апрель 17, 2022

A growing amount of information about the different types, functions, and roles played by non-coding RNAs (ncRNAs) is becoming available, as more research done. ncRNAs have been identified potential therapeutic targets in treatment tuberculosis (TB), because they may be essential regulators gene network. ncRNA profiling sequencing has recently revealed significant dysregulation tuberculosis, primarily due to aberrant processes synthesis, including amplification, deletion, improper epigenetic regulation, or abnormal transcription. Despite fact that a role TB characteristics, detailed mechanisms behind these occurrences are still unknown. The dark matter genome can only explored through development cutting-edge bioinformatics molecular technologies. In this review, ncRNAs’ synthesis functions discussed detail, with an emphasis on tuberculosis. We also focus current platforms, experimental strategies, computational analyses explore TB. Finally, viewpoint presented key challenges novel techniques for future wide-ranging application ncRNAs.

Язык: Английский

---