Journal of Pharmacy and Pharmacology,
Год журнала:
2023,
Номер
75(7), С. 910 - 920
Опубликована: Апрель 7, 2023
Abstract
Objectives
Rheumatoid
arthritis
(RA)
is
an
inflammatory
and
autoimmune
disease.
Studies
over
the
past
two
decades
suggest
that
statins
have
a
beneficial
impact
on
complications
associated
with
RA.
These
include
RA
disease
activity
risk
for
cardiovascular
diseases
(CVD).
This
review
aims
to
discuss
efficacy
of
statin
therapy
in
Key
findings
The
current
evidence
suggests
statins'
immunomodulatory
antioxidant
properties
significantly
reduce
response
patients
In
patients,
CVD
reduced
by
treatment,
discontinuation
increased
risk.
Summary
combined
effect
improving
vascular
function,
lowering
lipid
levels,
reducing
inflammation
responsible
decreased
all-cause
mortality
users.
Further
clinical
studies
are
needed
ensure
therapeutic
Current Medicinal Chemistry,
Год журнала:
2023,
Номер
31(13), С. 1726 - 1739
Опубликована: Фев. 7, 2023
Background:
Elevated
concentrations
of
serum
uric
acid
(SUA)
are
associated
with
several
conditions,
including
cardiovascular
disease.
The
present
study
aimed
to
estimate
the
impact
statin
therapy
on
SUA
levels
through
a
systematic
review
and
meta-analysis
clinical
trials.
Methods:
PubMed,
Embase,
Web
Science,
Scopus
were
searched
January
14,
2022,
identify
eligible
intervention
group
received
statins
as
monotherapy
or
in
combination
other
drugs,
control
non-statins
placebo.
Studies
reporting
before
after
treatment
selected
for
further
analysis.
Finally,
data
pooled,
mean
changes
SUA,
total
cholesterol,
high-density
lipoprotein
(HDL),
low-density
(LDL),
triglycerides
reported.
Results:
Out
1269
identified
studies,
23
included
review.
A
3928
participants
therapy,
1294
groups.
We
found
significant
reduction
following
(mean
difference
(MD)
=
-26.67
μmol/L
95%
confidence
interval
(CI)
[-44.75,
-8.60]
(P
=0.004)).
Atorvastatin
(MD
-37.93
[-67.71,
-8.15];
P
<
0.0001),
pravastatin
-12.64
[-18.64,
-6.65];
simvastatin
-5.95
[-6.14,
-5.80];
but
not
rosuvastatin,
significantly
levels.
An
analysis
comparing
different
types
showed
that
20-40
mg/day
could
reduce
when
compared
10-20
(-21.86
[-36.33,-7.39];
=0.003).
Conclusion:
Statins
decrease
levels,
particularly
atorvastatin,
which
was
be
most
effective
lowering
SUA.
may
appropriate
cholesterol-lowering
agent
patients
at
risk
hyperuricemia.
Pharmacological Reports,
Год журнала:
2024,
Номер
76(2), С. 235 - 250
Опубликована: Март 7, 2024
Traumatic
brain
injury
(TBI),
often
referred
to
as
the
"silent
epidemic",
is
most
common
cause
of
mortality
and
morbidity
worldwide
among
all
trauma-related
injuries.
It
associated
with
considerable
personal,
medical,
economic
consequences.
Although
remarkable
advances
in
therapeutic
approaches
have
been
made,
current
treatments
clinical
management
for
TBI
recovery
still
remain
be
improved.
One
factors
that
may
contribute
this
gap
existing
therapies
target
only
a
single
event
or
pathology.
However,
after
involves
various
pathological
mechanisms,
including
inflammation,
oxidative
stress,
blood-brain
barrier
(BBB)
disruption,
ionic
disturbance,
excitotoxicity,
mitochondrial
dysfunction,
neuronal
necrosis,
apoptosis.
Statins
several
beneficial
pleiotropic
effects
(anti-excitotoxicity,
anti-inflammatory,
anti-oxidant,
anti-thrombotic,
immunomodulatory
activity,
endothelial
vasoactive
properties)
addition
promoting
angiogenesis,
neurogenesis,
synaptogenesis
TBI.
Supposedly,
using
agents
such
statins
numerous
diverse
more
effective
than
single-target
approach
management.
The
review
was
undertaken
investigate
summarize
protective
mechanisms
against
limitations
conducted
studies
directions
future
research
on
potential
application
are
also
discussed.
Phytotherapy Research,
Год журнала:
2024,
Номер
38(8), С. 4081 - 4098
Опубликована: Июнь 20, 2024
Abstract
A
variety
of
mechanisms
and
drugs
have
been
shown
to
attenuate
cardiovascular
disease
(CVD)
onset
and/or
progression.
Recent
researchers
identified
a
potential
role
proprotein
convertase
subtilisin/kexin
type
9
(PCSK9)
in
modulating
lipid
metabolism
reducing
plasma
low
density
lipoprotein
(LDL)
levels.
PCSK9
is
the
central
protein
LDL
cholesterol
(LDL‐C)
owing
its
major
function
receptor
(LDLR)
degradation.
Due
close
correlation
with
levels,
many
vivo
vitro
investigations
are
currently
underway
studying
physiological
PCSK9.
Furthermore,
studies
actively
investigating
various
compounds
that
influence
associated‐disorders
their
associated
diseases.
inhibitors
significant
impact
prevention
emerging
Natural
products
can
effectively
be
used
as
control
levels
through
mechanisms.
In
this
review,
we
evaluate
phytochemicals
natural
regulation
PCSK9,
ability
prevent
Moreover,
describe
action,
which
not
date
delineated.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117093 - 117093
Опубликована: Июль 5, 2024
Protein
phosphorylation
is
an
important
link
in
a
variety
of
signaling
pathways,
and
most
the
life
processes
cells
involve
protein
phosphorylation.
Based
on
amino
acid
residues
phosphorylated
proteins,
kinases
can
be
categorized
into
following
families:
serine/threonine
kinases,
tyrosine-specific
histidine-specific
tryptophan
aspartate/glutamyl
kinases.
Of
all
are
where
that
catalyze
serine
or
threonine
target
proteins
using
ATP
as
phosphate
donor.
The
current
socially
accepted
classification
to
divide
them
seven
major
groups:
kinase
A,
G,
C
(AGC),
CMGC,
Calmodulin-dependent
(CAMK),
Casein
(CK1),
STE,
Tyrosine
(TKL)
others.
After
decades
research,
preliminary
understanding
specific
respective
functions
has
entered
new
period
exploration.
In
this
paper,
we
review
literature
previous
years
introduce
pathways
related
therapeutic
modalities
played
by
each
small
family,
respectively,
some
common
cardiovascular
system
diseases
such
heart
failure,
myocardial
infarction,
ischemia-reperfusion
injury,
diabetic
cardiomyopathy.
To
certain
extent,
research
results,
including
molecular
mechanisms
methods,
fully
summarized
systematic
report
made
for
prevention
treatment
future.
