Journal of Pharmacy and Pharmacology,
Год журнала:
2023,
Номер
75(7), С. 910 - 920
Опубликована: Апрель 7, 2023
Abstract
Objectives
Rheumatoid
arthritis
(RA)
is
an
inflammatory
and
autoimmune
disease.
Studies
over
the
past
two
decades
suggest
that
statins
have
a
beneficial
impact
on
complications
associated
with
RA.
These
include
RA
disease
activity
risk
for
cardiovascular
diseases
(CVD).
This
review
aims
to
discuss
efficacy
of
statin
therapy
in
Key
findings
The
current
evidence
suggests
statins'
immunomodulatory
antioxidant
properties
significantly
reduce
response
patients
In
patients,
CVD
reduced
by
treatment,
discontinuation
increased
risk.
Summary
combined
effect
improving
vascular
function,
lowering
lipid
levels,
reducing
inflammation
responsible
decreased
all-cause
mortality
users.
Further
clinical
studies
are
needed
ensure
therapeutic
Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Myocardial
ischemia-reperfusion
injury
(MI/RI)
is
a
critical
challenge
for
acute
myocardial
infarction
therapy,
as
there
currently
no
ideal
drug
available.
Glycogen
synthase
kinase
3
beta
(GSK-3β)
serves
an
promising
therapeutic
target
treating
MI/RI.
Our
previous
studies
have
demonstrated
that
Ilex
pubescens
ameliorates
The
purpose
of
this
study
to
evaluate
the
efficacy
and
potential
mechanism
screened
GSK-3β
inhibitor
from
against
Three-dimensional-quantitative
structure-activity
relationship
(3D-QSAR)
modeling,
molecular
docking,
oxygen
glucose
deprivation/reperfusion
(OGD/R)
left
anterior
descending
(LAD)
artery
ligation-induced
MI/RI
mice
model,
western
blotting
analysis
were
used
screen
investigate
protective
mechanism.
Here,
we
Pubescenoside
D
(PBD)
with
IC50
value
0.3769
μM
pubescens,
using
3D-QSAR
assay
verification.
Ile217,
Leu88,
Phe93,
Phe67
are
key
binding
sites
PBD
GSK-3β.
protects
cardiomyocytes
in
vitro
vivo.
Further
show
inhibits
mitochondrial
permeability
transition
pore
(mPTP)
opening
by
preventing
GSK-3β-mediated
dissociation
hexokinase2
(HK2)
outer
membrane
mitochondria
enhances
mitophagy
suppressing
activity,
subsequently
reducing
cardiomyocyte
apoptosis.
findings
shed
light
on
agent
treatment
targeting
Cell Death and Disease,
Год журнала:
2025,
Номер
16(1)
Опубликована: Апрель 6, 2025
Abstract
Protein
tyrosine
phosphatase
mitochondrial
1
(PTPMT1),
is
a
member
of
the
protein
superfamily
localized
on
inner
membrane,
and
regulates
biosynthesis
cardiolipin.
Given
important
position
PTPMT1
in
function
metabolism,
pharmacological
targeting
considered
promising
manner
disease
treatments.
In
this
study,
we
mainly
investigated
role
hepatocellular
carcinoma
(HCC)
ferroptosis,
new
type
cell
death
accompanied
by
significant
iron
accumulation
lipid
peroxidation.
Herein,
inhibition
was
induced
alexidine
dihydrochloride
(AD,
dibiguanide
compound).
Human
HCC
lines
with
knockout
overexpression
were
established
using
CRISPR/Cas9
lentiviral
transduction
methods,
respectively.
The
regulating
ferroptosis
evaluated
vitro
vivo.
Our
results
indicated
that
PTPMT1,
facilitated
AD
treatment,
heightens
susceptibility
to
cystine
deprivation-ferroptosis,
treatment
promoted
conversion
from
ferritin-bound
Fe
3+
free
2+
,
which
contributed
labile
pool
cytoplasm.
Meanwhile,
also
formation
both
swollen
mitochondria
donut
mitochondria,
enhanced
metabolism
process
form
succinate
fumarate
tricarboxylic
acid
(TCA)
cycle,
increased
sensitivity
cells
deprivation-induced
ferroptosis.
total,
our
work
reveals
close
association
cysteine
providing
novel
insight
into
chemotherapy
strategies
against
human
HCC.
European Journal of Pharmaceutical Sciences,
Год журнала:
2022,
Номер
178, С. 106284 - 106284
Опубликована: Авг. 26, 2022
Abdominal
aortic
aneurysm
(AAA)
is
a
prevalent
condition
which
causes
progressive
growth
and
rupture
of
wall
with
high
death
rate.
Several
studies
have
found
that
treatment
statins
may
decrease
the
progress
AAA
risk
by
suppressing
inflammatory
mediators,
decreasing
oxidative
stress,
inhibiting
mechanisms
involved
in
extracellular
matrix
(ECM)
degradation.
Moreover,
some
reported
prehospital
therapy
can
mortality
after
surgery.
The
novelty
this
paper
different
including
those
performed
humans
animals
were
reviewed
potential
an
effect
on
summarized.
Overall,
evidence
suggested
association
between
improvement
AAA.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(10), С. 5415 - 5415
Опубликована: Май 12, 2022
The
cardiovascular
benefit
of
statins
is
well
established.
However,
only
20%
high-risk
patients
remain
adequately
adherent
after
5
years
treatment.
Among
reasons
for
discontinuation,
statin
associated-muscle
pain
symptoms
are
the
most
prevalent.
Aim
present
study
was
to
evaluate
impact
high
dose
atorvastatin
on
skeletal
muscle
mitochondrial
activity,
aerobic
and
anaerobic
exercise,
axonal
excitability
in
a
murine
model
atherosclerosis.
ApoE-/-
mice
were
fed
12
weeks
high-fat
high-cholesterol
diet
alone
or
containing
(40
mg/Kg/day).
Outcomes
evaluation
functionality,
locomotion,
grip
test,
(compound
action
potential
recording
analysis
Aα
motor
propioceptive,
Aβ
mechanoceptive
C
nociceptive
fibres).
Atorvastatin
led
reduction
biogenesis
ATP
production.
It
did
not
affect
muscular
strength
but
time-dependent
impairment.
altered
responsiveness
fibres,
respectively,
fibres.
These
findings
point
out
mild
sensitization
mechanical,
tactile
sensitivity.
In
conclusion,
although
prevalence
side
effects
from
may
be
overestimated,
understanding
underlying
mechanisms
can
help
improve
therapeutic
approach
reassure
adherence
needing-to-be-treated.
Journal of Pharmacy and Pharmacology,
Год журнала:
2023,
Номер
75(7), С. 910 - 920
Опубликована: Апрель 7, 2023
Abstract
Objectives
Rheumatoid
arthritis
(RA)
is
an
inflammatory
and
autoimmune
disease.
Studies
over
the
past
two
decades
suggest
that
statins
have
a
beneficial
impact
on
complications
associated
with
RA.
These
include
RA
disease
activity
risk
for
cardiovascular
diseases
(CVD).
This
review
aims
to
discuss
efficacy
of
statin
therapy
in
Key
findings
The
current
evidence
suggests
statins'
immunomodulatory
antioxidant
properties
significantly
reduce
response
patients
In
patients,
CVD
reduced
by
treatment,
discontinuation
increased
risk.
Summary
combined
effect
improving
vascular
function,
lowering
lipid
levels,
reducing
inflammation
responsible
decreased
all-cause
mortality
users.
Further
clinical
studies
are
needed
ensure
therapeutic
