Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
177, P. 117093 - 117093
Published: July 5, 2024
Protein
phosphorylation
is
an
important
link
in
a
variety
of
signaling
pathways,
and
most
the
life
processes
cells
involve
protein
phosphorylation.
Based
on
amino
acid
residues
phosphorylated
proteins,
kinases
can
be
categorized
into
following
families:
serine/threonine
kinases,
tyrosine-specific
histidine-specific
tryptophan
aspartate/glutamyl
kinases.
Of
all
are
where
that
catalyze
serine
or
threonine
target
proteins
using
ATP
as
phosphate
donor.
The
current
socially
accepted
classification
to
divide
them
seven
major
groups:
kinase
A,
G,
C
(AGC),
CMGC,
Calmodulin-dependent
(CAMK),
Casein
(CK1),
STE,
Tyrosine
(TKL)
others.
After
decades
research,
preliminary
understanding
specific
respective
functions
has
entered
new
period
exploration.
In
this
paper,
we
review
literature
previous
years
introduce
pathways
related
therapeutic
modalities
played
by
each
small
family,
respectively,
some
common
cardiovascular
system
diseases
such
heart
failure,
myocardial
infarction,
ischemia-reperfusion
injury,
diabetic
cardiomyopathy.
To
certain
extent,
research
results,
including
molecular
mechanisms
methods,
fully
summarized
systematic
report
made
for
prevention
treatment
future.
European Journal of Pharmaceutical Sciences,
Journal Year:
2022,
Volume and Issue:
178, P. 106284 - 106284
Published: Aug. 26, 2022
Abdominal
aortic
aneurysm
(AAA)
is
a
prevalent
condition
which
causes
progressive
growth
and
rupture
of
wall
with
high
death
rate.
Several
studies
have
found
that
treatment
statins
may
decrease
the
progress
AAA
risk
by
suppressing
inflammatory
mediators,
decreasing
oxidative
stress,
inhibiting
mechanisms
involved
in
extracellular
matrix
(ECM)
degradation.
Moreover,
some
reported
prehospital
therapy
can
mortality
after
surgery.
The
novelty
this
paper
different
including
those
performed
humans
animals
were
reviewed
potential
an
effect
on
summarized.
Overall,
evidence
suggested
association
between
improvement
AAA.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(10), P. 5415 - 5415
Published: May 12, 2022
The
cardiovascular
benefit
of
statins
is
well
established.
However,
only
20%
high-risk
patients
remain
adequately
adherent
after
5
years
treatment.
Among
reasons
for
discontinuation,
statin
associated-muscle
pain
symptoms
are
the
most
prevalent.
Aim
present
study
was
to
evaluate
impact
high
dose
atorvastatin
on
skeletal
muscle
mitochondrial
activity,
aerobic
and
anaerobic
exercise,
axonal
excitability
in
a
murine
model
atherosclerosis.
ApoE-/-
mice
were
fed
12
weeks
high-fat
high-cholesterol
diet
alone
or
containing
(40
mg/Kg/day).
Outcomes
evaluation
functionality,
locomotion,
grip
test,
(compound
action
potential
recording
analysis
Aα
motor
propioceptive,
Aβ
mechanoceptive
C
nociceptive
fibres).
Atorvastatin
led
reduction
biogenesis
ATP
production.
It
did
not
affect
muscular
strength
but
time-dependent
impairment.
altered
responsiveness
fibres,
respectively,
fibres.
These
findings
point
out
mild
sensitization
mechanical,
tactile
sensitivity.
In
conclusion,
although
prevalence
side
effects
from
may
be
overestimated,
understanding
underlying
mechanisms
can
help
improve
therapeutic
approach
reassure
adherence
needing-to-be-treated.
Lipids in Health and Disease,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: May 25, 2024
The
degradation
of
low-density
lipoprotein
receptor
(LDLR)
is
induced
by
proprotein
convertase
subtilisin/kexin
type
9
(PCSK9),
resulting
in
elevated
plasma
concentrations
LDL
cholesterol.
Therefore,
inhibiting
the
interactions
between
PCSK9
and
LDLR
a
desirable
therapeutic
goal
for
managing
hypercholesterolemia.
Aptamers,
which
are
RNA
or
single-stranded
DNA
sequences,
can
recognize
their
targets
based
on
secondary
structure.
Aptamers
exhibit
high
selectivity
affinity
binding
to
target
molecules.
systematic
evolution
ligands
exponential
enrichment
(SELEX),
combination
biological
approaches,
used
screen
most
aptamers
vitro.
Due
unique
advantages,
have
garnered
significant
interest
since
discovery
found
extensive
applications
various
fields.
been
increasingly
utilized
development
biosensors
sensitive
detection
pathogens,
analytes,
toxins,
drug
residues,
malignant
cells.
Furthermore,
similar
monoclonal
antibodies,
serve
as
tools.
Unlike
certain
protein
therapeutics,
do
not
elicit
antibody
responses,
modified
sugars
at
2'-positions
generally
prevent
toll-like
receptor-mediated
innate
immune
responses.
focus
this
review
aptamer-based
targeting
application
both
agents.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
177, P. 117093 - 117093
Published: July 5, 2024
Protein
phosphorylation
is
an
important
link
in
a
variety
of
signaling
pathways,
and
most
the
life
processes
cells
involve
protein
phosphorylation.
Based
on
amino
acid
residues
phosphorylated
proteins,
kinases
can
be
categorized
into
following
families:
serine/threonine
kinases,
tyrosine-specific
histidine-specific
tryptophan
aspartate/glutamyl
kinases.
Of
all
are
where
that
catalyze
serine
or
threonine
target
proteins
using
ATP
as
phosphate
donor.
The
current
socially
accepted
classification
to
divide
them
seven
major
groups:
kinase
A,
G,
C
(AGC),
CMGC,
Calmodulin-dependent
(CAMK),
Casein
(CK1),
STE,
Tyrosine
(TKL)
others.
After
decades
research,
preliminary
understanding
specific
respective
functions
has
entered
new
period
exploration.
In
this
paper,
we
review
literature
previous
years
introduce
pathways
related
therapeutic
modalities
played
by
each
small
family,
respectively,
some
common
cardiovascular
system
diseases
such
heart
failure,
myocardial
infarction,
ischemia-reperfusion
injury,
diabetic
cardiomyopathy.
To
certain
extent,
research
results,
including
molecular
mechanisms
methods,
fully
summarized
systematic
report
made
for
prevention
treatment
future.
