Kinsenoside Alleviates Experimental Acute Pancreatitis by Suppressing M1 Macrophage Polarization via the TLR4/STAT1 Signaling Pathway DOI
Ruiyan Wang,

Jing Jiang,

Pengli Song

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119551 - 119551

Опубликована: Фев. 1, 2025

Язык: Английский

Jaceosidin attenuates the progression of hepatic fibrosis by inhibiting the VGLL3/HMGB1/TLR4 signaling pathway DOI
Youli Yao,

Xiaoling Zuo,

Feng Shao

и другие.

Phytomedicine, Год журнала: 2024, Номер 128, С. 155502 - 155502

Опубликована: Март 11, 2024

Язык: Английский

Процитировано

6

Pulsatile Flow Increases METTL14-induced m6A modification and attenuates septic cardiomyopathy: an experimental study DOI Creative Commons
Shenyu Zhu, Kai Wang, Zhexuan Yu

и другие.

International Journal of Surgery, Год журнала: 2024, Номер unknown

Опубликована: Март 28, 2024

Introduction: Septic cardiomyopathy is a sepsis-mediated cardiovascular complication with severe microcirculatory malperfusion. Emerging evidence has highlighted the protective effects of pulsatile flow in case disturbance, yet underlying mechanisms are still elusive. The objective this study was to investigate N6-methyladenosine (m 6 A) modification alleviation septic associated extracorporeal membrane oxygenation (ECMO)-generated flow. Methods: Rat model established and supported under ECMO either or non-pulsatile Peripheral perfusion index (PPI) cardiac function parameters were measured using ultrasonography. Dot blot assay applied examine m A level, while qRT-PCR, Western blot, immunofluorescence, immunohistochemistry used measure expressions related genes. RNA immunoprecipitation performed validate interaction between molecules. Results: ECMO-generated significantly elevates PPI, improves myocardial function, protects endothelium, prolongs survival rat models cardiomyopathy. mediates METTL14-mediated zonula occludens- (ZO-) 1 mRNA which stabilizes ZO-1 depending on presence YTHDF2. suppresses PI3K-Akt signaling pathway, downstream molecule Foxo1, negative transcription factor METTL14, binds METTL14 promoter inhibits METTL14-induced modification. Conclusion: increases attenuates progression cardiomyopathy, suggesting that pulsatility might be new therapeutic strategy by alleviating disturbance.

Язык: Английский

Процитировано

6

Multi-omics and multi-stages integration identified a novel variant associated with silicosis risk DOI

Chunmeng Jin,

Xiaobo Tao,

Wendi Zhang

и другие.

Archives of Toxicology, Год журнала: 2024, Номер 98(9), С. 2907 - 2918

Опубликована: Май 29, 2024

Язык: Английский

Процитировано

5

Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K–AKT signaling in rheumatoid arthritis DOI Creative Commons
Tingting Liu, Chao Jin, Jing Sun

и другие.

Chinese Medical Journal, Год журнала: 2024, Номер unknown

Опубликована: Июнь 14, 2024

Abstract Background: G protein-coupled receptor kinase 2 (GRK2) could participate in the regulation of diverse cells via interacting with non-G-protein-coupled receptors. In present work, we explored how paroxetine, a GRK2 inhibitor, modulates differentiation and activation immune rheumatoid arthritis (RA). Methods: The blood samples healthy individuals RA patients were collected between July 2021 March 2022 from First Affiliated Hospital Anhui Medical University. C57BL/6 mice used to induce collagen-induced (CIA) model. Flow cytometry analysis was characterize function dendritic (DCs)/T cells. Co-immunoprecipitation explore specific molecular mechanism. Results: RA, high expression peripheral lymphocytes, accompanied by increases phosphatidylinositol 3 (PI3K), protein B (AKT), mammalian target rapamycin (mTOR). animal model, decrease regulatory T (T regs ), an increase cluster 8 positive (CD8 + ) cells, maturation DCs observed. Paroxetine, when vitro CIA mice, restrained CD8 induced proportion . Paroxetine inhibited secretion pro-inflammatory cytokines, C-C motif chemokine 7 Simultaneously, paroxetine upregulated programmed death ligand 1, anti-inflammatory cytokines. Additionally, PI3K–AKT–mTOR metabolic pathway both This associated reduction mitochondrial membrane potential changes utilization glucose lipids, particularly DCs. reversed PI3K–AKT 740 Y-P (a PI3K agonist) through inhibiting interaction Conclusion: exerts immunosuppressive effect targeting GRK2, which subsequently inhibits metabolism-related cell RA.

Язык: Английский

Процитировано

5

Immune response gene 1 deficiency aggravates high fat diet-induced nonalcoholic fatty liver disease via promotion of redox-sensitive AKT suppression DOI Creative Commons
Xue Zhang,

Ying Zhi,

Xinyan Zan

и другие.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2023, Номер 1869(4), С. 166656 - 166656

Опубликована: Янв. 25, 2023

Язык: Английский

Процитировано

11

Identification of shared gene signatures and molecular mechanisms between chronic kidney disease and ulcerative colitis DOI Creative Commons
Liang Zhou, Xinrong Hu,

Ruoni Lin

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Фев. 13, 2023

There is a complex interaction between chronic kidney disease (CKD) and ulcerative colitis (UC), but the pathophysiological mechanisms underlying coexistence of CKD UC are unclear. This study aimed to investigate key molecules pathways that may mediate co-occurrence through quantitative bioinformatics analysis based on public RNA-sequencing database. The discovery datasets (GSE66494) (GSE4183), as well validation (GSE115857) (GSE10616), were downloaded from Gene Expression Omnibus (GEO) After identifying differentially expressed genes (DEGs) with GEO2R online tool, Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses for DEGs performed. Next, protein-protein network was constructed Search Tool Retrieval Interacting (STRING) visualized by Cytoscape. modules identified plug-in MCODE hub screened using CytoHubba. Then, correlation immune cell infiltration analyzed, receiver operating characteristic curves used assess predictive value genes. Finally, immunostaining human specimens validate relevant findings. A total 462 common selected further analyses. GO KEGG indicated these primarily enriched in immune- inflammation-related pathways. Among them, PI3K-Akt signaling ranked top both cohorts, signal molecule phosphorylated Akt (p-Akt) shown be significantly overexpressed kidneys colons, elevated CKD-UC comorbidity specimens. Moreover, nine candidate genes, including CXCL8, CCL2, CD44, ICAM1, IL1A, CXCR2, PTPRC, ITGAX, CSF3, identified, which ICAM1 validated gene. Besides, revealed neutrophils, macrophages, CD4+ T memory cells accumulated diseases, remarkably associated neutrophil infiltration. Furthermore, intercellular adhesion molecule1 (ICAM1)-mediated upregulated colon biopsies patients, increased patients diagnosed UC. had critical diagnostic marker Our elucidated response, pathway, ICAM1-mediated might pathogenesis UC, potential biomarker therapeutic target two diseases.

Язык: Английский

Процитировано

11

Calenduloside E ameliorates non-alcoholic fatty liver disease via modulating a pyroptosis-dependent pathway. DOI
Yifei Le,

Jianan Guo,

Zhijun Liu

и другие.

Journal of Ethnopharmacology, Год журнала: 2023, Номер 319, С. 117239 - 117239

Опубликована: Сен. 28, 2023

Язык: Английский

Процитировано

11

Ba-Qi-Rougan formula alleviates hepatic fibrosis by suppressing hepatic stellate cell activation via the MSMP/CCR2/PI3K pathway DOI Creative Commons

Yan Xue,

Wanchun Zhu,

Fengjie Qiao

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 329, С. 118169 - 118169

Опубликована: Апрель 16, 2024

The Ba-Qi-Rougan formula (BQRGF) is a traditional and effective compound prescription from Traditional Chinese Medicine (TCM) utilized in treating hepatic fibrosis (HF).

Язык: Английский

Процитировано

4

Advances in the therapeutic application and pharmacological properties of kinsenoside against inflammation and oxidative stress-induced disorders DOI Creative Commons
Li Lü, Yuan Xiong, Ze Lin

и другие.

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Окт. 4, 2022

Extensive research has implicated inflammation and oxidative stress in the development of multiple diseases, such as diabetes, hepatitis, arthritis. Kinsenoside (KD), a bioactive glycoside component extracted from medicinal plant Anoectochilus roxburghii , been shown to exhibit potent anti-inflammatory anti-oxidative abilities. In this review, we summarize effects KD, including hepatoprotection, pro-osteogenesis, anti-hyperglycemia, vascular protection, immune regulation, vision infection inhibition, which are partly responsible for suppressing signaling stress. The protective action KD against dysfunctional lipid metabolism is also associated with limiting inflammatory signals, due crosstalk between metabolism. Ferroptosis, process involved both damage, potentially regulated by KD. addition, discuss physicochemical properties pharmacokinetic profiles Advances cultivation artificial synthesis techniques promising evidence that shortage raw materials required production can be overcome. novel drug delivery systems improve vivo rapid clearance poor bioavailability integrated aim offer insights into molecular mechanisms underlying therapeutic role lay solid foundations utilization clinical practice.

Язык: Английский

Процитировано

16

The combination of gemcitabine and ginsenoside Rh2 enhances the immune function of dendritic cells against pancreatic cancer via the CARD9-BCL10-MALT1 / NF-κB pathway DOI
Qing Li, Jialuo He, Senlin Li

и другие.

Clinical Immunology, Год журнала: 2022, Номер 248, С. 109217 - 109217

Опубликована: Дек. 27, 2022

Язык: Английский

Процитировано

15