Integrated UHPLC-Q-Exactive Orbitrap HRMS and Serum Pharmacochemistry for the Investigation of Anti-hepatic Fibrosis Effect of BaoGanNing Decoction
Kaili Deng,
Min Li,
Liangliang Xiang
и другие.
Phytomedicine,
Год журнала:
2025,
Номер
137, С. 156363 - 156363
Опубликована: Янв. 2, 2025
Язык: Английский
Elucidation of Anti-Obesity Mechanisms of Phenolics in Artemisiae argyi Folium (Aiye) by Integrating LC-MS, Network Pharmacology, and Molecular Docking
Life,
Год журнала:
2024,
Номер
14(6), С. 656 - 656
Опубликована: Май 22, 2024
The
global
prevalence
of
obesity
is
a
pressing
health
issue,
increasing
the
medical
burden
and
posing
significant
risks
to
humans.
side
effects
complications
associated
with
conventional
medication
surgery
have
spurred
search
for
anti-obesity
drugs
from
plant
resources.
Previous
studies
suggested
that
Artemisiae
argyi
Folium
(Aiye)
water
extracts
could
inhibit
pancreatic
lipase
activities,
control
body
weight
increase,
improve
plasma
lipids
profile.
However,
exact
components
mechanisms
were
not
precisely
understood.
Therefore,
this
research
aims
identify
chemical
profile
Aiye
provide
comprehensive
prediction
its
mechanisms.
extract
was
subjected
LC-MS
analysis,
which
identified
30
phenolics.
these
phenolics
then
predicted,
employing
network
pharmacology
molecular
docking.
Among
phenolics,
21
passed
drug-likeness
screening
exhibited
486
targets.
enrichment
analysis
revealed
may
combat
through
PI3K-Akt
signaling
MAPK,
prolactin,
cAMP
pathways.
Eight
seven
central
targets
selected
docking,
45
out
56
docking
had
binding
affinity
less
than
−5
kcal/mol.
This
has
indicated
potential
therapy
pathways
in
combating
obesity.
Язык: Английский
HMGB1: key mediator in digestive system diseases
Inflammation Research,
Год журнала:
2025,
Номер
74(1)
Опубликована: Фев. 4, 2025
Язык: Английский
Jaceosidin overcomes osimertinib resistance in lung cancer by inducing G2/M cycle arrest through targeting DDB1
Toxicology and Applied Pharmacology,
Год журнала:
2025,
Номер
unknown, С. 117327 - 117327
Опубликована: Апрель 1, 2025
Язык: Английский
Natural Compounds in Cancer Therapy: Revealing the Role of Flavonoids in Renal Cell Carcinoma Treatment
Biomolecules,
Год журнала:
2025,
Номер
15(5), С. 620 - 620
Опубликована: Апрель 25, 2025
Renal
cell
carcinoma
(RCC)
is
the
most
lethal
malignancy
of
urinary
system,
with
limited
treatment
options
due
to
drug
resistance
and
adverse
effects
associated
current
therapies.
This
review
aims
systematically
examine
therapeutic
potential
flavonoids,
which
are
natural
polyphenolic
compounds
possessing
anti-inflammatory,
antioxidant,
anticancer
properties,
in
context
RCC
treatment.
We
summarize
activities
26
classified
into
six
subclasses,
explore
their
mechanisms
action,
including
inhibition
tumor
proliferation,
migration,
invasion,
as
well
induction
apoptosis,
autophagy,
ferroptosis.
Particular
attention
paid
modulation
key
signaling
pathways
such
JAK/STAT3,
PI3K/Akt/mTOR,
miRNA-related
axes,
miR-21/YAP1
miR-324-3p/GPX4,
providing
a
molecular
basis
for
anti-RCC
activity.
also
address
several
pharmacological
challenges
that
limit
clinical
application
poor
bioavailability,
metabolic
instability,
toxicity.
Emerging
solutions
novel
flavonoid
derivatives,
advanced
delivery
systems,
rational
combination
therapy
strategies
discussed.
Current
evidence,
phase
II
trial
flavopiridol
RCC,
highlights
but
need
further
validation.
In
conclusion,
flavonoids
offer
promising
approach
improving
Future
research
should
focus
on
optimizing
efficacy
ensuring
safe
translation,
goal
achieving
personalized
minimally
invasive
cancer
Язык: Английский
Mechanisms underlying the involvement of peritoneal macrophages in the pathogenesis and novel therapeutic strategies for dialysis-induced peritoneal fibrosis
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 19, 2024
Long-term
exposure
of
the
peritoneum
to
peritoneal
dialysate
results
in
pathophysiological
changes
anatomical
organization
and
progressive
development
fibrosis.
This
leads
a
decline
function
ultrafiltration
failure,
ultimately
necessitating
discontinuation
dialysis,
severely
limiting
potential
for
long-term
maintenance.
Additionally,
encapsulating
sclerosis,
serious
consequence
fibrosis,
resulting
patients
discontinuing
PD
significant
mortality.
The
causes
mechanisms
underlying
fibrosis
undergoing
dialysis
remain
unknown,
with
no
definitive
treatment
available.
However,
abnormal
activation
immune
system
appears
be
involved
altering
structure
promoting
fibrotic
changes.
Macrophage
infiltration
polarization
are
key
contributors
pathological
injury
within
peritoneum,
showing
strong
correlation
epithelial-to-mesenchymal
transition
mesothelial
cells
driving
process
article
discusses
role
macrophage
activation-induced
from
by
analyzing
relevant
literature
past
decade
provides
an
overview
recent
therapeutic
approaches
targeting
macrophages
treat
this
condition.
Язык: Английский