Mitochondria and ischemia reperfusion injury

Current Opinion in Organ Transplantation, Год журнала: 2022, Номер 27(5), С. 434 - 445

Опубликована: Авг. 3, 2022

This review describes the role of mitochondria in ischemia-reperfusion-injury (IRI).Mitochondria are power-house our cells and play a key for success organ transplantation. With their respiratory chain, main energy producers, to fuel metabolic processes, control cellular signalling provide electrochemical integrity. The mitochondrial metabolism is however severely disturbed when ischemia occurs. Cellular depletes rapidly various metabolites, including Succinate accumulate. At reperfusion, reactive oxygen species immediately released from complex-I initiate IRI-cascade inflammation. Prior development novel therapies, underlying mechanisms should be explored target best possible compound. A clinically relevant treatment recharge reduce accumulation before implantation. While many interventions focus instead on specific molecule, which may inhibit downstream IRI-inflammation, protection can directly achieved through hypothermic oxygenated perfusion (HOPE) transplantation.Mitochondria attractive targets molecules limit IRI-associated Although dynamic preservation techniques could serve as delivery tool new therapeutic interventions, own inherent mechanism not only studied, but considered injury, seen with HOPE-approach.

Язык: Английский

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Mitochondrial Quality Control: Its Role in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Journal of Obesity & Metabolic Syndrome, Год журнала: 2023, Номер 32(4), С. 289 - 302

Опубликована: Дек. 5, 2023

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty disease, is characterized by hepatic steatosis and metabolic dysfunction often associated with obesity insulin resistance. Recent research indicates a rapid escalation in MASLD cases, projections suggesting doubling the United States 2030. This review focuses on central role of mitochondria pathogenesis explores potential therapeutic interventions. Mitochondria are dynamic organelles that orchestrate energy production metabolism critically involved MASLD. Dysfunctional contribute to lipid accumulation, inflammation, fibrosis. Genetic associations further underscore relationship between mitochondrial dynamics susceptibility. Although U.S. Food Drug Administration-approved treatments for remain elusive, ongoing clinical trials have highlighted promising strategies target dysfunction, including vitamin E, metformin, glucagon-like peptide-1 receptor agonists. In preclinical studies, novel therapeutics, nicotinamide adenine dinucleotide

Язык: Английский

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Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 1735 - 1763

Опубликована: Март 1, 2024

Gouty arthritis (GA) is an immune-mediated disorder characterized by severe inflammation due to the deposition of monosodium urate (MSU) crystals in joints. The pathophysiological mechanisms GA are not yet fully understood, and therefore, identification effective therapeutic targets paramount importance. Neutrophil extracellular traps (NETs), intricate structure DNA scaffold, encompassing myeloperoxidase, histones, elastases - have gained significant attention as a prospective target for gouty arthritis, their innate antimicrobial immunomodulatory properties. Hence, exploring potential NETs remains enticing avenue further investigation. During process formation triggers release inflammatory cytokines, thereby contributing response, while MSU cytokines sequestered degraded aggregation NETs. Here, we provide concise summary processes underlying initiation resolution mediated Furthermore, this review presents overview current pharmacological approaches treating summarizes natural synthetic product-based inhibitors that NET novel options, alongside elucidating intrinsic challenges these research. Lastly, limitations HL-60 cell suitable substitute neutrophils research summarized discussed. Series recommendations provided, strategically oriented towards guiding future investigations effectively address concerns. These findings will contribute enhanced comprehension interplay between GA, facilitating proposition innovative strategies management GA.

Язык: Английский

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Anti-Aging Drugs and the Related Signal Pathways

Biomedicines, Год журнала: 2024, Номер 12(1), С. 127 - 127

Опубликована: Янв. 8, 2024

Aging is a multifactorial biological process involving chronic diseases that manifest from the molecular level to systemic level. From its inception 31 May 2022, this study searched PubMed, Web of Science, EBSCO, and Cochrane library databases identify relevant research 15,983 articles. Multiple approaches have been employed combat aging, such as dietary restriction (DR), exercise, exchanging circulating factors, gene therapy, anti-aging drugs. Among them, drugs are advantageous in their ease adherence wide prevalence. Despite shared functional output aging alleviation, current target different signal pathways frequently cross-talk with each other. At present, six important were identified being critical process, including for mechanistic rapamycin (mTOR), AMP-activated protein kinase (AMPK), nutrient pathway, silent information regulator factor 2-related enzyme 1 (SIRT1), regulation telomere length glycogen synthase kinase-3 (GSK-3), energy metabolism. These could be targeted by many drugs, corresponding representatives rapamycin, metformin, acarbose, nicotinamide adenine dinucleotide (NAD+), lithium, nonsteroidal anti-inflammatory (NSAIDs), respectively. This review summarized these aging-related representative targeting attempts obtain insights into promote development mechanism-based strategies.

Язык: Английский

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The involvement of the mitochondrial membrane in drug delivery

Acta Biomaterialia, Год журнала: 2024, Номер 176, С. 28 - 50

Опубликована: Янв. 26, 2024

Язык: Английский

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