Beneficial Effects of Red Wine Polyphenols on Human Health: Comprehensive Review

Current Issues in Molecular Biology, Год журнала: 2023, Номер 45(2), С. 782 - 798

Опубликована: Янв. 17, 2023

Polyphenols are secondary plant metabolites synthesized during the development of grape berry as a response to stress conditions. They important constituents in red wines that contribute sensory properties and antioxidant activity wines. Due highly sophisticated analytical devices, it is now possible characterize structure polymerized polyphenols obtain full polyphenol profile Red wine include ones present grapes well new products formed winemaking process. Among them, most groups their representatives flavanols (catechin), stilbenes (trans-resveratrol), flavonols (quercetin) hydroxybenzoic acids (gallic acid). It known exhibit beneficial effects on human health, such anti-inflammatory, anticarcinogenic cardio-protective effects. Many studies have been conducted health cancer chemopreventive activities, neuroprotective impact cardiovascular diseases, gut microbiota humans, etc. This review will provide major scientific findings main features.

Язык: Английский

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The Pharmacological Properties of Red Grape Polyphenol Resveratrol: Clinical Trials and Obstacles in Drug Development

Nutrients, Год журнала: 2023, Номер 15(20), С. 4486 - 4486

Опубликована: Окт. 23, 2023

Resveratrol is a stilbenoid from red grapes that possesses strong antioxidant activity. has been shown to have anticancer activity, making it promising drug for the treatment and prevention of numerous cancers. Several in vitro vivo investigations validated resveratrol’s capabilities, demonstrating its ability block all steps carcinogenesis (such as initiation, promotion, progression). Additionally, resveratrol found auxiliary pharmacological effects such anti-inflammatory, cardioprotective, neuroprotective Despite properties, several obstacles, poor solubility bioavailability, well adverse effects, continue be key obstacles development. This review critically evaluates clinical trials date aims develop framework into clinically viable drug.

Язык: Английский

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Bioactivities and mechanism of action of securinega alkaloids derivatives reported prior to 2022

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 158, С. 114190 - 114190

Опубликована: Янв. 4, 2023

Securinega alkaloids are indolizidine extracted from the leaf and root of an Asian plant, suffruticosa. Since its discovery in 1956 by Russian scientists, numerous studies have been conducted on securinega their derivatives as bioactive agents. In this review, published work bioactivities mechanism action is addressed. References were obtained through for example, Web Science, Science Direct, Pubmed Google Scholar. Research into synthesis lacking activity assessment has excluded. Comprehensive reviews show that exhibit a wide range activities among which antineoplastic nervous system related reported although mechanisms remain part unknown. The other such induction differentiation, reversal multi-drug resistance, cardiovascular activity, anti-inflammatory, adjuvant agent anti-pathogenic also reviewed. We found modification at C12, C14, C15 sites securinine improves antitumor while bivalent mimetic linked to site beneficial differentiation P-glycoprotein mediated drug resistance. most pathways involved bioactivity JAK/STAT, PI3K/AKT/mTOR MAPK. A perspective expectation concerning research presented end article. This review indicates directions around constant endeavor could be valuable researchers near future.

Язык: Английский

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The potential of curcumin in mitigating acetaminophen-induced liver damage

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Язык: Английский

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Superoxide dismutase: a key target for the neuroprotective effects of curcumin

Molecular and Cellular Biochemistry, Год журнала: 2023, Номер 479(3), С. 693 - 705

Опубликована: Май 11, 2023

Язык: Английский

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Modulatory Effects of Phytochemicals on Gut–Brain Axis: Therapeutic Implication

Current Developments in Nutrition, Год журнала: 2024, Номер 8(6), С. 103785 - 103785

Опубликована: Май 22, 2024

Язык: Английский

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The role of polyphenols in modulating mitophagy: Implications for therapeutic interventions

Pharmacological Research, Год журнала: 2024, Номер 207, С. 107324 - 107324

Опубликована: Июль 24, 2024

This review rigorously assesses the burgeoning research into role of polyphenols in modulating mitophagy, an essential cellular mechanism for targeted removal impaired mitochondria. These natural compounds, known their low toxicity, are underscored potential therapeutic strategies against a diverse array diseases, such as neurodegenerative, cardiovascular, and musculoskeletal disorders. The analysis penetrates deeply molecular mechanisms whereby promote particularly by influencing crucial signaling pathways transcriptional regulators, including phosphatase tensin homolog (PTEN) induced putative kinase 1 (PINK1)/parkin forkhead box O3 (FOXO3a) pathways. Noteworthy discoveries include neuroprotective properties resveratrol curcumin, which affect both autophagic mitochondrial dynamics, pioneering integration with other substances to amplify effectiveness. Furthermore, confronts issue polyphenol bioavailability emphasizes imperative clinical trials corroborate viability. By delivering exhaustive synthesis contemporary insights recent advancements mitophagy research, this endeavors catalyze additional foster creation innovative modalities that exploit distinctive attributes manage prevent disease.

Язык: Английский

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Polyphenol extract ameliorates diabetes-related atherosclerosis through HIF-1 signaling pathway in APOE−/- mice: possible synergism with atorvastatin

Phytomedicine, Год журнала: 2025, Номер 140, С. 156572 - 156572

Опубликована: Фев. 25, 2025

Язык: Английский

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An Overview of Bioactive Phenolic Molecules and Antioxidant Properties of Beer: Emerging Trends

Molecules, Год журнала: 2023, Номер 28(7), С. 3221 - 3221

Опубликована: Апрель 4, 2023

Beer is one of the oldest and most common beverages worldwide. The phenolic contents antioxidant properties beer are crucial factors in evaluating its nutritional quality. Special beers brewed with addition adjuncts gaining consumer preference, response to demands for healthy food new gustatory olfactory stimuli. Many studies recently dealt functional adjuncts. This review focuses on bioactive molecules, particularly composition compounds, activity beer. current knowledge concerning effect form fruit, vegetables, herbs, natural foods polyphenol content, properties, profile reviewed, an outline emerging trends brewing processes. Future need complete identification characterization molecules beer, as well studying their absorption metabolic fate humans.

Язык: Английский

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Nature’s Arsenal: Harnessing the Capacity of Phytochemicals to Enhance Immune Checkpoint Inhibitor Therapy of Cancers: An Especial Attention to Brain Malignancies

Cancer Letters, Год журнала: 2024, Номер 593, С. 216955 - 216955

Опубликована: Май 14, 2024

Язык: Английский

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