Modulatory properties of curcumin in cancer: A narrative review on the role of interferons DOI
Sajjad Chamani, Maryam Moossavi, Ali Naghizadeh

et al.

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(3), P. 1003 - 1014

Published: Feb. 6, 2023

The immune network is an effective of cell types and chemical compounds established to maintain the body's homeostasis from foreign threats prevent risk a wide range diseases; hence, its proper functioning balance are essential. A dysfunctional system can contribute various disorders, including cancer. Therefore, there has been considerable interest in molecules that modulate network. Curcumin, active ingredient turmeric, one these herbal remedies with many beneficial effects, modulation immunity. Curcumin managing chronic inflammatory conditions, improving brain function, lowering cardiovascular disease risk, prevention management dementia, aging. Several clinical studies have supported this evidence, suggesting curcumin immunomodulatory anti-inflammatory function; nevertheless, mechanism action still not clear. In current review, we aim explore modulatory function through interferons cancers.

Language: Английский

Beneficial Effects of Red Wine Polyphenols on Human Health: Comprehensive Review DOI Creative Commons
Ivana Buljeta, Anita Pichler, Josip Šimunović

et al.

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(2), P. 782 - 798

Published: Jan. 17, 2023

Polyphenols are secondary plant metabolites synthesized during the development of grape berry as a response to stress conditions. They important constituents in red wines that contribute sensory properties and antioxidant activity wines. Due highly sophisticated analytical devices, it is now possible characterize structure polymerized polyphenols obtain full polyphenol profile Red wine include ones present grapes well new products formed winemaking process. Among them, most groups their representatives flavanols (catechin), stilbenes (trans-resveratrol), flavonols (quercetin) hydroxybenzoic acids (gallic acid). It known exhibit beneficial effects on human health, such anti-inflammatory, anticarcinogenic cardio-protective effects. Many studies have been conducted health cancer chemopreventive activities, neuroprotective impact cardiovascular diseases, gut microbiota humans, etc. This review will provide major scientific findings main features.

Language: Английский

Citations

60
The Pharmacological Properties of Red Grape Polyphenol Resveratrol: Clinical Trials and Obstacles in Drug Development DOI Open Access
Mohd Farhan, Asim Rizvi

Nutrients, Journal Year: 2023, Volume and Issue: 15(20), P. 4486 - 4486

Published: Oct. 23, 2023

Resveratrol is a stilbenoid from red grapes that possesses strong antioxidant activity. has been shown to have anticancer activity, making it promising drug for the treatment and prevention of numerous cancers. Several in vitro vivo investigations validated resveratrol’s capabilities, demonstrating its ability block all steps carcinogenesis (such as initiation, promotion, progression). Additionally, resveratrol found auxiliary pharmacological effects such anti-inflammatory, cardioprotective, neuroprotective Despite properties, several obstacles, poor solubility bioavailability, well adverse effects, continue be key obstacles development. This review critically evaluates clinical trials date aims develop framework into clinically viable drug.

Language: Английский

Citations

35
Bioactivities and mechanism of action of securinega alkaloids derivatives reported prior to 2022 DOI Open Access
Wen Hou, Hao Huang, Xueqiang Wu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 158, P. 114190 - 114190

Published: Jan. 4, 2023

Securinega alkaloids are indolizidine extracted from the leaf and root of an Asian plant, suffruticosa. Since its discovery in 1956 by Russian scientists, numerous studies have been conducted on securinega their derivatives as bioactive agents. In this review, published work bioactivities mechanism action is addressed. References were obtained through for example, Web Science, Science Direct, Pubmed Google Scholar. Research into synthesis lacking activity assessment has excluded. Comprehensive reviews show that exhibit a wide range activities among which antineoplastic nervous system related reported although mechanisms remain part unknown. The other such induction differentiation, reversal multi-drug resistance, cardiovascular activity, anti-inflammatory, adjuvant agent anti-pathogenic also reviewed. We found modification at C12, C14, C15 sites securinine improves antitumor while bivalent mimetic linked to site beneficial differentiation P-glycoprotein mediated drug resistance. most pathways involved bioactivity JAK/STAT, PI3K/AKT/mTOR MAPK. A perspective expectation concerning research presented end article. This review indicates directions around constant endeavor could be valuable researchers near future.

Language: Английский

Citations

24
Superoxide dismutase: a key target for the neuroprotective effects of curcumin DOI
Danial Khayatan, Seyed Mehrad Razavi, Zahra Najafi Arab

et al.

Molecular and Cellular Biochemistry, Journal Year: 2023, Volume and Issue: 479(3), P. 693 - 705

Published: May 11, 2023

Language: Английский

Citations

17
Modulatory Effects of Phytochemicals on Gut–Brain Axis: Therapeutic Implication DOI Creative Commons

Khojasteh Rahimi Jaberi,

Vahab Alamdari-Palangi,

Amir Savardashtaki

et al.

Current Developments in Nutrition, Journal Year: 2024, Volume and Issue: 8(6), P. 103785 - 103785

Published: May 22, 2024

Language: Английский

Citations

7
The role of polyphenols in modulating mitophagy: Implications for therapeutic interventions DOI Creative Commons
Xinyu Lin, Wenkai Liu, Xizhuo Hu

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 207, P. 107324 - 107324

Published: July 24, 2024

This review rigorously assesses the burgeoning research into role of polyphenols in modulating mitophagy, an essential cellular mechanism for targeted removal impaired mitochondria. These natural compounds, known their low toxicity, are underscored potential therapeutic strategies against a diverse array diseases, such as neurodegenerative, cardiovascular, and musculoskeletal disorders. The analysis penetrates deeply molecular mechanisms whereby promote particularly by influencing crucial signaling pathways transcriptional regulators, including phosphatase tensin homolog (PTEN) induced putative kinase 1 (PINK1)/parkin forkhead box O3 (FOXO3a) pathways. Noteworthy discoveries include neuroprotective properties resveratrol curcumin, which affect both autophagic mitochondrial dynamics, pioneering integration with other substances to amplify effectiveness. Furthermore, confronts issue polyphenol bioavailability emphasizes imperative clinical trials corroborate viability. By delivering exhaustive synthesis contemporary insights recent advancements mitophagy research, this endeavors catalyze additional foster creation innovative modalities that exploit distinctive attributes manage prevent disease.

Language: Английский

Citations

6
An Overview of Bioactive Phenolic Molecules and Antioxidant Properties of Beer: Emerging Trends DOI Creative Commons
Mirella Nardini

Molecules, Journal Year: 2023, Volume and Issue: 28(7), P. 3221 - 3221

Published: April 4, 2023

Beer is one of the oldest and most common beverages worldwide. The phenolic contents antioxidant properties beer are crucial factors in evaluating its nutritional quality. Special beers brewed with addition adjuncts gaining consumer preference, response to demands for healthy food new gustatory olfactory stimuli. Many studies recently dealt functional adjuncts. This review focuses on bioactive molecules, particularly composition compounds, activity beer. current knowledge concerning effect form fruit, vegetables, herbs, natural foods polyphenol content, properties, profile reviewed, an outline emerging trends brewing processes. Future need complete identification characterization molecules beer, as well studying their absorption metabolic fate humans.

Language: Английский

Citations

16
Nature’s Arsenal: Harnessing the Capacity of Phytochemicals to Enhance Immune Checkpoint Inhibitor Therapy of Cancers: An Especial Attention to Brain Malignancies DOI
Amir R. Afshari, Mehdi Sanati,

Seyed Sajad Ahmadi

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 593, P. 216955 - 216955

Published: May 14, 2024

Language: Английский

Citations

5
Passivation protein-adhesion platform promoting stent reendothelialization using two-electron-assisted oxidation of polyphenols DOI
Linhua Li, Chunle Zhang,

Zhengjiang Cao

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 305, P. 122423 - 122423

Published: Dec. 16, 2023

Language: Английский

Citations

12
Protective Effects of Plant-Derived Compounds Against Traumatic Brain Injury DOI Creative Commons
Danial Khayatan, Seyed Mehrad Razavi, Zahra Najafi Arab

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(10), P. 7732 - 7750

Published: March 1, 2024

Inflammation in the nervous system is one of key features many neurodegenerative diseases. It increasingly being identified as a critical pathophysiological primitive mechanism associated with chronic diseases following traumatic brain injury (TBI). Phytochemicals have wide range clinical properties due to their antioxidant and anti-inflammatory effects. Currently, there are few drugs available for treatment other than symptomatic relief. Numerous studies shown that plant-derived compounds, particular polyphenols, protect against various safe consumption. Polyphenols exert protective effects on TBI via restoration nuclear factor kappa B (NF-κB), toll-like receptor-4 (TLR4), Nod-like receptor family proteins (NLRPs) pathways. In addition, these phytochemicals derivatives upregulate phosphatidylinositol-3-Kinase/Protein Kinase (PI3K/AKT) erythroid 2-related 2 (Nrf2) pathways, which functions modulating symptoms. There supporting evidence medicinal plants different models, though future trials needed clarify precise mechanisms polyphenolic compounds TBI.

Language: Английский

Citations

4