Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 43 - 76
Опубликована: Янв. 1, 2024
Язык: Английский
Current Opinion in Endocrinology Diabetes and Obesity, Год журнала: 2024, Номер 31(3), С. 122 - 130
Опубликована: Апрель 8, 2024
This review critically examines interconnected health domains like gut microbiome, bone health, interleukins, chronic periodontitis, and coronavirus disease 2019 (COVID-19), offering insights into fundamental mechanisms clinical implications, contributing significantly to healthcare biomedical research.
Язык: Английский
Процитировано
14
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 6218 - 6218
Опубликована: Июнь 5, 2024
Although good glycemic control in patients with type 2 diabetes (T2D) can prevent cardiovascular complications, many diabetic still have poor optimal control. A new class of antidiabetic drugs (e.g., glucagon-like peptide-1-GLP-1 receptor agonists, sodium-glucose co-transporters-SGLT2 inhibitors), addition to the low hypoglycemic effect, exert multiple beneficial effects at a metabolic and level, through mechanisms other than antihyperglycemic agents. This review aims discuss these drugs, highlighting benefits, description their action as well available data by preclinical clinical studies. Moreover, innovative tools T2D field will be described which may help advance towards better targeted personalized care future.
Язык: Английский
Процитировано
9
Diabetes & Metabolic Syndrome Clinical Research & Reviews, Год журнала: 2024, Номер 18(8), С. 103110 - 103110
Опубликована: Авг. 1, 2024
Язык: Английский
Процитировано
7
Pharmacological Research, Год журнала: 2024, Номер 210, С. 107483 - 107483
Опубликована: Ноя. 8, 2024
The global epidemic of type 2 diabetes mellitus (T2DM) imposes a substantial burden on public health and healthcare expenditures, thereby driving the pursuit cost-effective preventive therapeutic strategies. Emerging evidence suggests potential association between dysbiosis gut microbiota its metabolites with T2DM, indicating that targeted interventions aimed at modulating may represent promising approach for management T2DM. In this review, we concentrated multifaceted interactions intestinal barrier in context We systematically summarized imbalance beneficial constitute viable Meanwhile, mechanisms by which interventions, such as probiotics, prebiotics, postbiotics, synbiotics, synergistically improve insulin resistance T2DM are summarized. These include restoration structure, upregulation epithelial cell proliferation differentiation, enhancement tight junction protein expression, promotion mucin secretion goblet cells, immunosuppressive functions regulatory T cells (Treg) M2 macrophages. Collectively, these actions contribute to amelioration body's metabolic inflammatory status. Our objective is furnish supports clinical application postbiotics
Язык: Английский
Процитировано
7
Diabetes Care, Год журнала: 2024, Номер 47(5), С. 787 - 789
Опубликована: Апрель 19, 2024
Язык: Английский
Процитировано
5
Clinical Nutrition, Год журнала: 2024, Номер 43(6), С. 1563 - 1583
Опубликована: Май 10, 2024
Язык: Английский
Процитировано
5
Food & Function, Год журнала: 2024, Номер 15(13), С. 6825 - 6846
Опубликована: Янв. 1, 2024
The gut microbiota is essential in human health, influencing various physiological processes ranging from digestion and metabolism to immune function mental health.
Язык: Английский
Процитировано
5
Metabolism Open, Год журнала: 2024, Номер 22, С. 100287 - 100287
Опубликована: Май 19, 2024
The complex and multidimensional landscape of type 2 diabetes mellitus (T2D) is a major global concern. Despite several years extensive research, the precise underlying causes T2D remain elusive, but evidence suggests that it influenced by myriad interconnected risk factors such as epigenetics, genetics, gut microbiome, environmental factors, organelle stress, dietary habits. number influencing pathogenesis increasing day which worsens scenario; meanwhile, interconnections shoot up frame. By gaining deeper insights into contributing we may pave way for development personalized medicine, could unlock more impactful treatment pathways individuals with T2D. This review summarizes state knowledge about pathogenesis, focusing on interplay between various their implications future therapeutic strategies. Understanding these lead to tailored treatments targeting specific inform prevention efforts population level, ultimately improving outcomes reducing its burden globally.
Язык: Английский
Процитировано
4
Journal of Autoimmunity, Год журнала: 2025, Номер 151, С. 103371 - 103371
Опубликована: Янв. 29, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3752 - 3752
Опубликована: Апрель 16, 2025
The gut microbiota, shaped by factors such as diet, lifestyle, and genetics, plays a pivotal role in regulating host metabolism, immune function, overall health. diversity balance of the microbiota are closely linked to onset progression various chronic diseases. A growing body evidence has demonstrated that alterations composition, metabolites significantly associated with cardiovascular diseases, including hypertension, atherosclerosis, heart failure; metabolic disorders obesity, type 2 diabetes, dysfunction-associated steatotic liver disease; gastrointestinal conditions like inflammatory bowel disease colorectal cancer. Despite substantial advances microbiome research, challenges remain fully elucidating causal relationships between disease, well translating these insights into clinical applications. This review aims investigate regulatory pathways via which affects health, disease. Additionally, it highlights emerging strategies for prevention treatment conditions, focusing on microbiota-targeted therapies personalized dietary interventions promising approaches improving health outcomes.
Язык: Английский
Процитировано
0