Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 43 - 76
Published: Jan. 1, 2024
Language: Английский
Current Opinion in Endocrinology Diabetes and Obesity, Journal Year: 2024, Volume and Issue: 31(3), P. 122 - 130
Published: April 8, 2024
This review critically examines interconnected health domains like gut microbiome, bone health, interleukins, chronic periodontitis, and coronavirus disease 2019 (COVID-19), offering insights into fundamental mechanisms clinical implications, contributing significantly to healthcare biomedical research.
Language: Английский
Citations
14
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6218 - 6218
Published: June 5, 2024
Although good glycemic control in patients with type 2 diabetes (T2D) can prevent cardiovascular complications, many diabetic still have poor optimal control. A new class of antidiabetic drugs (e.g., glucagon-like peptide-1-GLP-1 receptor agonists, sodium-glucose co-transporters-SGLT2 inhibitors), addition to the low hypoglycemic effect, exert multiple beneficial effects at a metabolic and level, through mechanisms other than antihyperglycemic agents. This review aims discuss these drugs, highlighting benefits, description their action as well available data by preclinical clinical studies. Moreover, innovative tools T2D field will be described which may help advance towards better targeted personalized care future.
Language: Английский
Citations
9
Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2024, Volume and Issue: 18(8), P. 103110 - 103110
Published: Aug. 1, 2024
Language: Английский
Citations
7
Pharmacological Research, Journal Year: 2024, Volume and Issue: 210, P. 107483 - 107483
Published: Nov. 8, 2024
The global epidemic of type 2 diabetes mellitus (T2DM) imposes a substantial burden on public health and healthcare expenditures, thereby driving the pursuit cost-effective preventive therapeutic strategies. Emerging evidence suggests potential association between dysbiosis gut microbiota its metabolites with T2DM, indicating that targeted interventions aimed at modulating may represent promising approach for management T2DM. In this review, we concentrated multifaceted interactions intestinal barrier in context We systematically summarized imbalance beneficial constitute viable Meanwhile, mechanisms by which interventions, such as probiotics, prebiotics, postbiotics, synbiotics, synergistically improve insulin resistance T2DM are summarized. These include restoration structure, upregulation epithelial cell proliferation differentiation, enhancement tight junction protein expression, promotion mucin secretion goblet cells, immunosuppressive functions regulatory T cells (Treg) M2 macrophages. Collectively, these actions contribute to amelioration body's metabolic inflammatory status. Our objective is furnish supports clinical application postbiotics
Language: Английский
Citations
7
Diabetes Care, Journal Year: 2024, Volume and Issue: 47(5), P. 787 - 789
Published: April 19, 2024
Language: Английский
Citations
5
Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(6), P. 1563 - 1583
Published: May 10, 2024
Language: Английский
Citations
5
Food & Function, Journal Year: 2024, Volume and Issue: 15(13), P. 6825 - 6846
Published: Jan. 1, 2024
The gut microbiota is essential in human health, influencing various physiological processes ranging from digestion and metabolism to immune function mental health.
Language: Английский
Citations
5
Metabolism Open, Journal Year: 2024, Volume and Issue: 22, P. 100287 - 100287
Published: May 19, 2024
The complex and multidimensional landscape of type 2 diabetes mellitus (T2D) is a major global concern. Despite several years extensive research, the precise underlying causes T2D remain elusive, but evidence suggests that it influenced by myriad interconnected risk factors such as epigenetics, genetics, gut microbiome, environmental factors, organelle stress, dietary habits. number influencing pathogenesis increasing day which worsens scenario; meanwhile, interconnections shoot up frame. By gaining deeper insights into contributing we may pave way for development personalized medicine, could unlock more impactful treatment pathways individuals with T2D. This review summarizes state knowledge about pathogenesis, focusing on interplay between various their implications future therapeutic strategies. Understanding these lead to tailored treatments targeting specific inform prevention efforts population level, ultimately improving outcomes reducing its burden globally.
Language: Английский
Citations
4
Journal of Autoimmunity, Journal Year: 2025, Volume and Issue: 151, P. 103371 - 103371
Published: Jan. 29, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3752 - 3752
Published: April 16, 2025
The gut microbiota, shaped by factors such as diet, lifestyle, and genetics, plays a pivotal role in regulating host metabolism, immune function, overall health. diversity balance of the microbiota are closely linked to onset progression various chronic diseases. A growing body evidence has demonstrated that alterations composition, metabolites significantly associated with cardiovascular diseases, including hypertension, atherosclerosis, heart failure; metabolic disorders obesity, type 2 diabetes, dysfunction-associated steatotic liver disease; gastrointestinal conditions like inflammatory bowel disease colorectal cancer. Despite substantial advances microbiome research, challenges remain fully elucidating causal relationships between disease, well translating these insights into clinical applications. This review aims investigate regulatory pathways via which affects health, disease. Additionally, it highlights emerging strategies for prevention treatment conditions, focusing on microbiota-targeted therapies personalized dietary interventions promising approaches improving health outcomes.
Language: Английский
Citations
0