Progress in targeting PTEN/PI3K/Akt axis in glioblastoma therapy: Revisiting molecular interactions

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 158, С. 114204 - 114204

Опубликована: Янв. 4, 2023

Glioblastoma (GBM) is one of the most malignant cancers central nervous system and due to its sensitive location, surgical resection has high risk therefore, chemotherapy radiotherapy are utilized for treatment. However, chemoresistance radio-resistance other problems in GBM Hence, new therapies based on genes recommended treatment GBM. PTEN a tumor-suppressor operator cancer that inhibits PI3K/Akt/mTOR axis diminishing growth, metastasis drug resistance. In current review, function PTEN/PI3K/Akt progression evaluated. Mutation or depletion leads increase progression. Low expression level mediates poor prognosis by increasing proliferation invasion, promotes malignancy tumor cells. Moreover, loss signaling can result therapy resistance Activation impairs metabolism via glycolysis inhibition. contrast PTEN, PI3K/Akt oncogenic during progression, enhances. shows positive association with pathways similar signaling, regulated non-coding RNAs. upregulation inhibition anti-cancer agents be beneficial interfering This review emphasizes networks related provides insights targeting this effective

Язык: Английский

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Apoptotic Mechanisms of Quercetin in Liver Cancer: Recent Trends and Advancements

Pharmaceutics, Год журнала: 2023, Номер 15(2), С. 712 - 712

Опубликована: Фев. 20, 2023

Due to rising incidence rates of liver cancer and worries about the toxicity current chemotherapeutic medicines, hunt for further alternative methods treat this malignancy has escalated. Compared chemotherapy, quercetin, a flavonoid, is relatively less harmful normal cells regarded as an excellent free-radical scavenger. Apoptotic cell death caused by quercetin been demonstrated many prior studies. It present in fruits, vegetables, herbs. Quercetin targets apoptosis, upregulating Bax, caspase-3, p21 while downregulating Akt, PLK-1, cyclin-B1, cyclin-A, CDC-2, CDK-2, Bcl-2. Additionally, it reported increase STAT3 protein degradation decreasing activation. potential future chemoprevention, based on substantial research its anticancer effects. The review discusses quercetin’s mechanisms action, nanodelivery strategies, other cellular effects cancer.

Язык: Английский

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Pien-Tze-Huang prevents hepatocellular carcinoma by inducing ferroptosis via inhibiting SLC7A11-GSH-GPX4 axis

Cancer Cell International, Год журнала: 2023, Номер 23(1)

Опубликована: Июнь 6, 2023

Abstract Background Malignant transformation from hepatic fibrosis to carcinogenesis may be a therapeutic target for hepatocellular carcinoma (HCC). The aim of this study was evaluate anti-cancer efficacy Pien-Tze-Huang (PZH), and investigate the underlying mechanisms by integrating transcriptional regulatory network analysis experimental validation. Methods A diethylnitrosamine (DEN)-induced HCC model in rats established used PZH. After detecting transcriptomic profiling, “disease-related gene–drug effective target” interaction constructed, candidate targets PZH against malignant were identified verified vitro. Results effectively alleviated pathological changes cirrhosis, inhibited tumor formation growth DEN-induced rats. Additionally, administration reduced levels various function-related serological indicators significantly. Mechanically, ferroptosis-related SLC7A11-GSH-GPX4 axis might one potential HCC. Especially, high SLC7A11 expression associated with poor prognosis patients. Experimentally, markedly increased trivalent iron ferrous ion, suppressed GPX4 proteins, GSH/GSSG ratio liver tissues Conclusions Our data offer an evidence that improve microenvironment prevent occurrence through promoting ferroptosis cells via inhibiting axis, implying drug prevention treatment at early stage.

Язык: Английский

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Amino acid transporters within the solute carrier superfamily: Underappreciated proteins and novel opportunities for cancer therapy

Molecular Metabolism, Год журнала: 2024, Номер 84, С. 101952 - 101952

Опубликована: Май 3, 2024

Solute carrier (SLC), a diverse family of membrane proteins, are instrumental in orchestrating the intake and efflux nutrients including amino acids, vitamins, ions, nutrients, etc, across cell membranes. This dynamic process is critical for sustaining metabolic demands cancer cells, promoting their survival, proliferation, adaptation to tumor microenvironment. Amino acids fundamental building blocks playing essential roles not only protein synthesis but also nutrient sensing, signaling pathways that can promote tumorigenesis. As key transporters SLCs have emerged as crucial players maintaining cellular acid homeostasis, dysregulation implicated various types. Thus, understanding intricate connections between SLCs, pivotal unraveling novel therapeutic targets strategies. uptake by positively affects progression. However, some studies revealed suppressor function SLCs. Although body evaluated SLC7A11 SLC1A5, SLC proteins studied sufficiently cancer. In this review, we delve into significant impact carriers on growth progression explore current state knowledge field, shedding light molecular mechanisms underlie these relationships highlighting potential avenues future research clinical interventions. comprehensive review provides insights rapidly evolving area biology focusing one most important materials cells need, within superfamily.

Язык: Английский

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ARID4B Promotes the Progression of Hepatocellular Carcinoma Through the PI3K/AKT Pathway

Annals of Surgical Oncology, Год журнала: 2025, Номер 32(4), С. 3009 - 3018

Опубликована: Янв. 3, 2025

Язык: Английский

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Immune Checkpoints and the Immunology of Liver Fibrosis

Livers, Год журнала: 2025, Номер 5(1), С. 5 - 5

Опубликована: Янв. 27, 2025

Liver fibrosis is a very complicated dynamic process where several immune cells are involved. Both innate and adaptive immunity implicated, their interplay always present. Multi-directional interactions between liver macrophages, hepatic stellate (HSCs), cells, cytokines important for the induction perpetuation of fibrosis. Detailed studies proteomics transcriptomics have produced new evidence role individual in cirrhosis. Most these controlled by various checkpoints whose main function to maintain homeostasis implicated cells. Recent indicates that involved In particular, programmed cell death protein 1 (PD-1), death-ligand (PD-L1), cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) been investigated, particularly after availability checkpoint inhibitors. Their activation leads exhaustion CD4+ve CD8+ve promotion this review, current pathogenesis immunological abnormalities discussed. The recent data on involvement identified as possible targets future interventions.

Язык: Английский

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Deciphering STAT3 signaling potential in hepatocellular carcinoma: tumorigenesis, treatment resistance, and pharmacological significance

Cellular & Molecular Biology Letters, Год журнала: 2023, Номер 28(1)

Опубликована: Апрель 21, 2023

Abstract Hepatocellular carcinoma (HCC) is considered one of the greatest challenges to human life and most common form liver cancer. Treatment HCC depends on chemotherapy, radiotherapy, surgery, immunotherapy, all which have their own drawbacks, patients may develop resistance these therapies due aggressive behavior cells. New effective for can be developed by targeting molecular signaling pathways. The expression signal transducer activator transcription 3 (STAT3) in cancer cells changes, during progression, tends increase. After induction STAT3 growth factors cytokines, phosphorylated translocated nucleus regulate progression. concept current review revolves around phosphorylation status HCC, studies show that high progression HCC. This addresses function as an oncogenic factor able prevent apoptosis thus promote Moreover, regulates both survival- death-inducing autophagy promotes metastasis inducing epithelial–mesenchymal transition (EMT). In addition, upregulation associated with occurrence chemoresistance radioresistance Specifically, non-protein-coding transcripts inhibition antitumor agents affect tumor this review, topics are discussed detail provide further insight into role tumorigenesis, treatment resistance, pharmacological regulation Graphical

Язык: Английский

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Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro

International Immunopharmacology, Год журнала: 2023, Номер 117, С. 110042 - 110042

Опубликована: Март 20, 2023

Язык: Английский

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Deciphering the immune modulation through deep transcriptomic profiling and therapeutic implications of DNA damage repair pattern in hepatocellular carcinoma

Cancer Letters, Год журнала: 2023, Номер 582, С. 216594 - 216594

Опубликована: Дек. 20, 2023

Язык: Английский

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Interventing mitochondrial PD-L1 suppressed IFN-γ-induced cancer stemness in hepatocellular carcinoma by sensitizing sorafenib-induced ferroptosis

Free Radical Biology and Medicine, Год журнала: 2024, Номер 212, С. 360 - 374

Опубликована: Янв. 1, 2024

Язык: Английский

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