The Science of The Total Environment, Год журнала: 2024, Номер 946, С. 174246 - 174246
Опубликована: Июнь 30, 2024
Язык: Английский
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 162, С. 114669 - 114669
Опубликована: Апрель 8, 2023
N6-methyladenosine (m6A) modification, as one of the most common types inner RNA modification in eukaryotes, plays a multifunctional role normal and abnormal biological processes. This type is modulated by m6A writer, eraser reader, which turn impact various processes metabolism, such processing, translation, nuclear export, localization decay. The current academic view holds that exerts crucial post-transcriptional modulation gene expression, involved multiple cellular functions, developmental disease However, potential molecular mechanism specific development liver have not been fully elucidated. In our review, we summarized latest research progress on disease, explored how these novel findings reshape knowledge metabolism. addition, also illustrated effect regeneration to prompt further exploration physiology pathology, providing new insights references for search therapeutic targets disease.
Язык: Английский
Процитировано
30
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Июнь 6, 2023
Rheumatoid arthritis (RA) has a high prevalence in patients with non-alcoholic fatty liver disease (NAFLD); however, the underlying mechanism is unclear. To address this, our study established rat model both NAFLD and RA by feeding high-fat diet (HFD) administering intradermal injection of Freund's complete adjuvant (FCA) bovine type II collagen. Collagen-induced (CIA) was confirmed hind paw swelling histological examination. The histomorphological characteristics were evaluated Masson's trichrome hematoxylin-eosin staining. development further measuring serum concentrations triglyceride (TG), total cholesterol (T-CHO), alanine aminotransferase (ALT), aspartate (AST), lipopolysaccharide (LPS). results showed that HFD exacerbated secondary inflammation CIA rats, whereas FCA/bovine collagen increased levels ALT, AST, TG, T-CHO, LPS hepatic fibrosis normal rats. Interestingly, + significantly promoted expression PTRF, caveolae structure protein involved lipid metabolism affecting downstream signaling Toll-like receptor 4 (TLR4) PI3K/Akt activation. High resolution confocal microscopy revealed PTRF TLR4 co-localization small vessels AAV9-mediated knockdown inhibited alleviated Together, these findings indicate combined causes synovial injury enhances could attenuate symptoms likely TLR4/PTRF co-expression signaling.
Язык: Английский
Процитировано
28
CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(2)
Опубликована: Фев. 1, 2024
Depression is the most disabling neuropsychiatric disorder, causing difficulties in daily life activities and social interactions. The exact mechanisms of depression remain largely unclear. However, some studies have shown that mitochondrial dysfunction would play a crucial role occurrence development depression.
Язык: Английский
Процитировано
16
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2025, Номер 1871(3), С. 167659 - 167659
Опубликована: Янв. 7, 2025
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(24), С. 17514 - 17514
Опубликована: Дек. 15, 2023
Nonalcoholic fatty liver disease (NAFLD) has become an increasingly common in Western countries and the major cause of cirrhosis or hepatocellular carcinoma (HCC) addition to viral hepatitis recent decades. Furthermore, studies have shown that NAFLD is inextricably linked development extrahepatic diseases. However, there currently no effective treatment cure NAFLD. In addition, 2020, was renamed metabolic dysfunction (MAFLD) show its pathogenesis closely related disorders. Recent reported MAFLD associated with mitochondrial hepatocytes hepatic stellate cells (HSCs). Simultaneously, stress caused by structural functional disorders stimulates occurrence accumulation fat lipo-toxicity HSCs. interaction between liver-gut axis also a new point during MAFLD. this review, we summarize effects several potential strategies for MAFLD, including antioxidants, reagents, intestinal microorganisms metabolites.
Язык: Английский
Процитировано
21
Clinical and Translational Medicine, Год журнала: 2023, Номер 13(8)
Опубликована: Авг. 1, 2023
N6 -methyladenosine (m6A) is of great importance in renal physiology and disease progression, but its function mechanism fibrosis remain to be comprehensively extensively explored. Hence, this study will explore the potential critical regulator-mediated m6A modification during thereby promising anti-renal agents.Renal tissues from humans mice as well HK-2 cells were used research subjects. The profiles regulators analysed at protein RNA levels using Western blotting, quantitative real-time polymerase chain reaction other methods. Methylation immunoprecipitation sequencing coupled with methyltransferase-like 3 (METTL3) conditional knockout METTL3 targets. Gene silencing overexpression combined performed investigate underlying by which regulates Ena/VASP-like (EVL) that promotes fibrosis. Molecular docking virtual screening vitro vivo experiments applied screen traditional Chinese medicine (TCM) monomers their regulating METTL3/EVL axis fibrosis.METTL3 modifications hyperactivated both tubular region fibrotic kidneys cells. Upregulated enhanced EVL mRNA improve stability expression an insulin-like growth factor 2 mRNA-binding (IGF2BP2)-dependent manner. Highly expressed binding Smad7 abrogated Smad7-induced suppression transforming factor-β (TGF-β1)/Smad3 signal transduction, conversely facilitated progression. based on structure identified a TCM monomer named isoforsythiaside, inhibited activity together exert effects.Collectively, overactivated target for therapy, pharmacological inhibition isoforsythiaside suggests it agent.
Язык: Английский
Процитировано
20
Experimental Cell Research, Год журнала: 2024, Номер 440(2), С. 114135 - 114135
Опубликована: Июнь 18, 2024
Язык: Английский
Процитировано
6
Science China Life Sciences, Год журнала: 2024, Номер 67(10), С. 2105 - 2119
Опубликована: Май 27, 2024
Abstract Non-alcoholic fatty liver disease (NAFLD) has emerged as a prominent global health concern associated with high risk of metabolic syndrome, and impacted substantial segment the population. The spectrum ranges from simple to non-alcoholic steatohepatitis (NASH), which can progress cirrhosis hepatocellular carcinoma (HCC) is increasingly becoming prevalent indication for transplantation. existing therapeutic options NAFLD, NASH, HCC are limited, underscoring urgent need innovative treatment strategies. Insights into gene expression, particularly RNA modifications such N 6 methyladenosine (m A), hold promising avenues interventions. These play integral roles in metabolism cellular functions, encompassing entire NAFLD-NASH-HCC progression. This review will encompass recent insights on diverse modifications, including m A, pseudouridine (ψ), 1 -methyladenosine 5-methylcytidine 5 C) across various species. It uncover their significance crucial aspects steatosis, inflammation, fibrosis, tumorigenesis. Furthermore, prospective research directions implications be explored, advancing our comprehensive understanding intricate interconnected nature these pathological conditions.
Язык: Английский
Процитировано
5
Clinical Epigenetics, Год журнала: 2024, Номер 16(1)
Опубликована: Сен. 12, 2024
Язык: Английский
Процитировано
5
Cellular Signalling, Год журнала: 2024, Номер 115, С. 111035 - 111035
Опубликована: Янв. 3, 2024
Язык: Английский
Процитировано
4