Microfluidic systems for modeling digestive cancer: a review of recent progress

Biomedical Physics & Engineering Express, Год журнала: 2024, Номер 10(5), С. 052002 - 052002

Опубликована: Авг. 14, 2024

Abstract Purpose . This review aims to highlight current improvements in microfluidic devices designed for digestive cancer simulation. The emphasizes the use of multicellular 3D tissue engineering models understand complicated biology tumor microenvironment (TME) and progression. purpose is develop oncology research improve patients’ lives. Methods analyzes recent on mimicking cancer. It uses tissue-engineered devices, notably organs a chip (OOC), simulate human organ function lab. Cell cultivation modern three-dimensional hydrogel platforms allows precise geometry, biological components, physiological qualities. novel methodologies, key findings, technical progress explain this field’s advances. Results study discusses advances Micro systems with are emphasized. These capture complex biochemical gradients, niche variables, dynamic cell–cell interactions (TME). reveal stomach progression by duplicating TME. Recent discoveries technology have improved our understanding gut biology, as shown review. Conclusion Microfluidic play crucial role modeling furthering research. could transform drug development treatment revealing provides complete summary suggests future field professionals. review’s major goal further medical

Язык: Английский

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Roadblocks confronting widespread dissemination and deployment of Organs on Chips

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 15, 2024

Organ on Chip platforms hold significant promise as alternatives to animal models or traditional cell cultures, both of which poorly recapitulate human pathophysiology and level responses. Within the last 15 years, we have witnessed seminal scientific developments from academic laboratories, a flurry startups investments, genuine interest pharmaceutical industry well regulatory authorities translate these platforms. This Perspective identifies several fundamental design process features that may act roadblocks prevent widespread dissemination deployment systems, provides roadmap help position this technology in mainstream drug discovery.

Язык: Английский

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Organoid, organ-on-a-chip and traditional Chinese medicine

Chinese Medicine, Год журнала: 2025, Номер 20(1)

Опубликована: Фев. 12, 2025

Abstract In the past few years, emergence of organoids and organ-on-a-chip (OOAC) technologies, which are complementary to animal models two-dimensional cell culture methods can better simulate internal environment human body, provides a new platform for traditional Chinese medicine (TCM) studies. Organoids OOAC techniques have been increasingly applied in fields drug screening, assessment development, personalized therapies, developmental biology, there some application cases TCM this review, we summarized current status using organoid technologies research provide key insights future study. It is believed that will play more important roles make greater contributions innovative development TCM.

Язык: Английский

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A review: early detection of oral cancer biomarkers using microfluidic colorimetric point-of-care devices

Analytical Methods, Год журнала: 2024, Номер 16(36), С. 6098 - 6118

Опубликована: Янв. 1, 2024

A comprehensive salivary biomarker study for oral cancer identification is carried out. Lateral flow assays (LFAs) and paper-based devices, low-resource settings, have been extensively examined.

Язык: Английский

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A three-dimensional (3D) liver–kidney on a chip with a biomimicking circulating system for drug safety evaluation

Lab on a Chip, Год журнала: 2024, Номер 24(6), С. 1715 - 1726

Опубликована: Янв. 1, 2024

A 3D liver–kidney on a chip with biomimicking circulating system (LKOCBCS) was constructed to obtain kidney and liver models in vitro for drug safety evaluation.

Язык: Английский

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Toxicokinetic analysis of the highly toxic nerve agent VX in commercially available multi-organ-chips – Ways to overcome compound absorption

Toxicology Letters, Год журнала: 2024, Номер 393, С. 78 - 83

Опубликована: Фев. 3, 2024

Язык: Английский

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Chitosan-polylactic acid composites: from seafood waste to advanced functional materials for 3D printing

Advanced Composites and Hybrid Materials, Год журнала: 2024, Номер 8(1)

Опубликована: Дек. 21, 2024

Abstract The development of functional and sustainable materials for additive manufacturing is a rapidly expanding area interest. In this context, composite blends chitosan—including commercial low medium molecular weight variants, as well laboratory-extracted chitosan from shrimp head shell waste—and polylactic acid (PLA) were prepared using extrusion molding. Filament characterization was conducted to explore the effects content on filament properties melt flow index, tensile testing, dynamic mechanical analysis (DMA), differential scanning calorimetry (DSC). morphology extruded filaments analyzed electron microscopy (SEM). Additionally, possibility incorporating high ratio metal into without compromising their printability structural integrity investigated. results indicated that certain compositions chitosan-PLA enable effective incorporation nickel, highlighting potential innovative catalyst supports. 3D printed in molten state, resulting specimens subsequently examined micro-CT. This approach seeks create an material food waste, offering circular solution transforming seafood waste advanced materials. successful integration waste-derived PLA not only enhances properties, but also demonstrates creating high-value products bio-waste, contributing environmental sustainability advancing field eco-friendly manufacturing. work highlights promising application various industrial sectors, emphasizing role promoting economy.

Язык: Английский

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Proximal tubule-on-chip as a model for predicting cation transport and drug transporter dynamics

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 20, 2025

Язык: Английский

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Exploring the landscape of current in vitro and in vivo models and their relevance for targeted radionuclide theranostics

European Journal of Nuclear Medicine and Molecular Imaging, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

Abstract Cancer remains a leading cause of mortality globally, driving ongoing research into innovative treatment strategies. Preclinical forms the base for developing these novel treatments, using both in vitro and vivo model systems that are, ideally, as clinically representative possible. Emerging promising approach cancer management, targeted radionuclide theranostics (TRT) uses radiotracers to deliver (cytotoxic) radionuclides specifically cells. Since field is relatively new, more advanced preclinical models are not yet regularly applied TRT research. This narrative review examines currently vitro, ex oncological research, discusses if how now studies, whether can be benefit field. A selection different discussed, ranging from two-dimensional (2D) three-dimensional (3D) cell models, including spheroids, organoids tissue slice cultures, mouse such cellline-derived patient-derived xenograft humanized models. Each has advantages limitations studying human biology, radiopharmaceutical assessment efficacy. Overall, there need apply better address specific phenomena, crossfire abscopal effects, enhance clinical relevance effectiveness evaluations.

Язык: Английский

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Integrating a Microphysiological System and Physiologically Based Pharmacokinetic Modeling to Predict Human Responses to Diclofenac

BioChip Journal, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

Язык: Английский

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