Handbook of experimental pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Biomedical Physics & Engineering Express, Journal Year: 2024, Volume and Issue: 10(5), P. 052002 - 052002
Published: Aug. 14, 2024
Abstract Purpose . This review aims to highlight current improvements in microfluidic devices designed for digestive cancer simulation. The emphasizes the use of multicellular 3D tissue engineering models understand complicated biology tumor microenvironment (TME) and progression. purpose is develop oncology research improve patients’ lives. Methods analyzes recent on mimicking cancer. It uses tissue-engineered devices, notably organs a chip (OOC), simulate human organ function lab. Cell cultivation modern three-dimensional hydrogel platforms allows precise geometry, biological components, physiological qualities. novel methodologies, key findings, technical progress explain this field’s advances. Results study discusses advances Micro systems with are emphasized. These capture complex biochemical gradients, niche variables, dynamic cell–cell interactions (TME). reveal stomach progression by duplicating TME. Recent discoveries technology have improved our understanding gut biology, as shown review. Conclusion Microfluidic play crucial role modeling furthering research. could transform drug development treatment revealing provides complete summary suggests future field professionals. review’s major goal further medical
Language: Английский
Citations
14
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: June 15, 2024
Organ on Chip platforms hold significant promise as alternatives to animal models or traditional cell cultures, both of which poorly recapitulate human pathophysiology and level responses. Within the last 15 years, we have witnessed seminal scientific developments from academic laboratories, a flurry startups investments, genuine interest pharmaceutical industry well regulatory authorities translate these platforms. This Perspective identifies several fundamental design process features that may act roadblocks prevent widespread dissemination deployment systems, provides roadmap help position this technology in mainstream drug discovery.
Language: Английский
Citations
8
Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)
Published: Feb. 12, 2025
Abstract In the past few years, emergence of organoids and organ-on-a-chip (OOAC) technologies, which are complementary to animal models two-dimensional cell culture methods can better simulate internal environment human body, provides a new platform for traditional Chinese medicine (TCM) studies. Organoids OOAC techniques have been increasingly applied in fields drug screening, assessment development, personalized therapies, developmental biology, there some application cases TCM this review, we summarized current status using organoid technologies research provide key insights future study. It is believed that will play more important roles make greater contributions innovative development TCM.
Language: Английский
Citations
1
Analytical Methods, Journal Year: 2024, Volume and Issue: 16(36), P. 6098 - 6118
Published: Jan. 1, 2024
A comprehensive salivary biomarker study for oral cancer identification is carried out. Lateral flow assays (LFAs) and paper-based devices, low-resource settings, have been extensively examined.
Language: Английский
Citations
5
Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(6), P. 1715 - 1726
Published: Jan. 1, 2024
A 3D liver–kidney on a chip with biomimicking circulating system (LKOCBCS) was constructed to obtain kidney and liver models in vitro for drug safety evaluation.
Language: Английский
Citations
4
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 20, 2025
Language: Английский
Citations
0
European Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 28, 2025
Abstract Cancer remains a leading cause of mortality globally, driving ongoing research into innovative treatment strategies. Preclinical forms the base for developing these novel treatments, using both in vitro and vivo model systems that are, ideally, as clinically representative possible. Emerging promising approach cancer management, targeted radionuclide theranostics (TRT) uses radiotracers to deliver (cytotoxic) radionuclides specifically cells. Since field is relatively new, more advanced preclinical models are not yet regularly applied TRT research. This narrative review examines currently vitro, ex oncological research, discusses if how now studies, whether can be benefit field. A selection different discussed, ranging from two-dimensional (2D) three-dimensional (3D) cell models, including spheroids, organoids tissue slice cultures, mouse such cellline-derived patient-derived xenograft humanized models. Each has advantages limitations studying human biology, radiopharmaceutical assessment efficacy. Overall, there need apply better address specific phenomena, crossfire abscopal effects, enhance clinical relevance effectiveness evaluations.
Language: Английский
Citations
0
BioChip Journal, Journal Year: 2025, Volume and Issue: unknown
Published: April 4, 2025
Language: Английский
Citations
0
Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101323 - 101323
Published: April 1, 2025
Language: Английский
Citations
0
Toxicology Letters, Journal Year: 2024, Volume and Issue: 393, P. 78 - 83
Published: Feb. 3, 2024
Language: Английский
Citations
3