Journal of Neurochemistry,
Год журнала:
2024,
Номер
169(1)
Опубликована: Дек. 18, 2024
Abstract
The
α4β2
nicotinic
acetylcholine
receptor
(nAChR),
an
ionophore,
has
been
suggested
to
signal
through
metabotropic
pathways
and
interact
with
other
families,
such
as
dopamine
receptors.
In
this
study,
the
interaction
between
nAChR
receptors
was
investigated
in
vivo
vitro
studies.
Nicotine
exposure
adolescent
rats
is
known
induce
a
sustained
increase
nicotine's
rewarding
effects
which
assessed
by
conditioned
place
preference
(CPP)
assay.
expression
levels
of
D
2
/D
3
(D
R,
R)
increased
after
nicotine
treatment.
To
determine
these
two
treatment,
newly
developed
ligand
high
selectivity
for
R
used
radioligand
binding
Although
both
enhanced
during
adolescence,
only
elevated
level
persisted
into
adulthood.
experiments
conducted
on
mice,
knockout
mice
showed
significantly
lower
CPP
scores
adulthood
compared
wild‐type
mice.
Cellular
studies
that
attributed
promoter
activity,
regulated
signaling
cascade
composed
Src,
Syk,
PKC,
NF‐κB.
These
results
demonstrate
pathway
involved
also
suggest
how
reward
initiated
adolescence
could
relapse
long
abstinence
period.
Given
significance
addiction,
study
thought
offer
novel
mechanistic
perspective
understanding
relapse.
image
Cells,
Год журнала:
2024,
Номер
13(6), С. 474 - 474
Опубликована: Март 7, 2024
Parkinson’s
disease
(PD)
is
a
progressive
neurodegenerative
characterized
by
resting
tremor,
bradykinesia,
rigidity,
and
postural
instability
that
also
includes
non-motor
symptoms
such
as
mood
dysregulation.
Dopamine
(DA)
the
primary
neurotransmitter
involved
in
this
disease,
but
cholinergic
imbalance
has
been
implicated.
Current
intervention
PD
focused
on
replenishing
central
DA,
which
provides
remarkable
temporary
symptomatic
relief
does
not
address
neuronal
loss
progression
of
disease.
It
well
established
nicotinic
receptors
(nAChRs)
can
regulate
DA
release
nicotine
itself
may
have
neuroprotective
effects.
Recent
studies
identified
nAChRs
nonneuronal
cell
types,
including
glial
cells,
where
they
inflammatory
responses.
Given
crucial
role
neuroinflammation
dopaminergic
degeneration
involvement
microglia
astrocytes
response,
provide
novel
therapeutic
target
prevention
and/or
treatment
PD.
In
review,
following
brief
discussion
PD,
we
focus
cells
and,
specifically,
their
pathology
treatment.
Biomedicines,
Год журнала:
2024,
Номер
12(4), С. 880 - 880
Опубликована: Апрель 16, 2024
Glutamate
is
the
major
excitatory
neurotransmitter
in
central
nervous
system.
Glutamatergic
transmission
can
be
mediated
by
ionotropic
glutamate
receptors
(iGluRs),
which
mediate
rapid
synaptic
depolarization
that
associated
with
Ca2+
entry
and
activity-dependent
change
strength
of
transmission,
as
well
metabotropic
(mGluRs),
slower
postsynaptic
responses
through
recruitment
second
messenger
systems.
A
wealth
evidence
reported
over
last
three
decades
has
shown
this
dogmatic
subdivision
between
iGluRs
mGluRs
may
not
reflect
actual
physiological
signaling
mode
iGluRs,
i.e.,
α-amino-3-hydroxy-5-methyl-4-isoxasolepropionic
acid
(AMPA)
(AMPAR),
kainate
(KARs),
N-methyl-D-aspartate
(NMDA)
(NMDARs).
Herein,
we
review
available
supporting
notion
canonical
recruit
flux-independent
pathways
only
neurons,
but
also
brain
astrocytes
cerebrovascular
endothelial
cells.
Understanding
versatility
exert
a
profound
impact
on
our
understanding
glutamatergic
synapses.
Furthermore,
it
shed
light
novel
neuroprotective
strategies
against
disorders.
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Март 12, 2025
Nicotinic
acetylcholine
receptors
(nAChRs)
are
widely
expressed
in
a
variety
of
cell
types
and
involved
multiple
physiological
regulatory
mechanisms
cells,
tissues
systems.
Increasing
evidence
suggests
that
the
α5
nicotinic
receptor
(α5-nAChR),
encoded
by
CHRNA5
gene,
is
one
key
mediator
lung
cancer
development
immune
responses.
Several
studies
have
shown
it
regulator
stimulates
processes
via
various
signaling
pathways,
including
STAT3
cancer.
In
addition,
α5-nAChR
has
profound
effect
on
response
through
immune-related
factor
pathways.
this
review,
we
focus
perspectives
progression,
which
indicates
targeting
could
provide
novel
anticancer
therapy
strategies
for
Marine Drugs,
Год журнала:
2024,
Номер
22(4), С. 147 - 147
Опубликована: Март 26, 2024
Nicotine
binds
to
nicotinic
acetylcholine
receptors
(nAChRs)
that
are
overexpressed
in
different
cancer
cells,
promoting
tumor
growth
and
resistance
chemotherapy.
In
this
study,
we
aimed
investigate
the
potential
of
APS7-2
APS8-2,
synthetic
analogs
a
marine
sponge
toxin,
inhibit
nicotine-mediated
effects
on
A549
human
lung
cells.
Our
electrophysiological
measurements
confirmed
APS8-2
act
as
α7
nAChR
antagonists.
showed
no
cytotoxicity
while
concentration-dependent
The
cytotoxic
responses
emphasize
importance
chemical
structure
determining
their
Nicotine-mediated
include
increased
cell
viability
proliferation,
elevated
intracellular
calcium
levels,
reduced
cisplatin-induced
reactive
oxygen
species
production
(ROS)
These
nicotine
were
effectively
attenuated
by
whereas
was
less
effective.
results
suggest
is
promising
new
therapeutic
agent
chemotherapy
cancer.
ACS Chemical Neuroscience,
Год журнала:
2024,
Номер
15(11), С. 2322 - 2333
Опубликована: Май 28, 2024
Nicotinic
acetylcholine
receptors
(nAChRs)
are
a
family
of
ligand-gated
ion
channel
that
contribute
to
cognition,
memory,
and
motor
control
in
many
organisms.
The
pharmacological
targeting
these
receptors,
using
small
molecules
or
peptides,
presents
an
important
strategy
for
the
development
drugs
can
treat
human
diseases,
including
neurodegenerative
disorders.
Aplysia
californica
binding
protein
(Ac-AChBP)
is
structural
surrogate
nAChR
with
high
homology
extracellular
ligand
domain
homopentameric
nAChRs.
In
this
study,
we
optimized
protein-painting-based
mass
spectrometry
identify
regions
interaction
between
Ac-AChBP
several
ligands.
Using
molecular
dyes
adhere
surface
solubilized
complex,
identified
amino
acid
residues
constitute
contact
site
within
α-bungarotoxin,
choline,
nicotine,
amyloid-β
1–42.
By
integrating
innovation
painting
computational
modeling,
present
new
experimental
tool
analyzing
interactions
nAChR.
