Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 309 - 326
Опубликована: Ноя. 1, 2024
Язык: Английский
Journal of Ethnopharmacology, Год журнала: 2025, Номер 349, С. 119872 - 119872
Опубликована: Май 5, 2025
Язык: Английский
Процитировано
0
Toxins, Год журнала: 2024, Номер 16(7), С. 301 - 301
Опубликована: Июль 1, 2024
Alternative recombinant sources of antivenoms have been successfully generated. The application such strategies requires the characterization venoms for development specific neutralizing molecules against toxic components. Five peptides to mammals from Mexican scorpion
Язык: Английский
Процитировано
3
International Immunopharmacology, Год журнала: 2024, Номер 132, С. 111960 - 111960
Опубликована: Март 29, 2024
Язык: Английский
Процитировано
2
Biomolecules, Год журнала: 2024, Номер 14(5), С. 545 - 545
Опубликована: Май 1, 2024
Enterovirus 71 (EV71), a typical representative of unenveloped RNA viruses, is the main pathogenic factor responsible for hand, foot, and mouth disease (HFMD) in infants. This seriously threatens health lives humans worldwide, especially Asia–Pacific region. Numerous animal antimicrobial peptides have been found with protective functions against bacteria, fungi, parasites, other pathogens, but there are few studies on use scorpion-derived viruses. Here, we investigated antiviral activities scorpion venom peptide BmKn2 five derivatives, finding that its derivative BmKn2-T5 exhibit significant inhibitory effect EV71. Although both characteristics amphiphilic α-helices terms their secondary structure, displayed lower cellular cytotoxicity than BmKn2. was further to inhibit EV71 dose-dependent manner vitro. Moreover, time-of-drug-addition experiments showed mainly restricts EV71, not virion or replication, at early stages viral cycle. Interestingly, also suppress replication enveloped viruses DENV, ZIKV, HSV-1 cycle, which suggests they may share common infection step Together, results our study identified valuable properties vitro, making it potential new candidate therapeutic molecule.
Язык: Английский
Процитировано
2
Molecules, Год журнала: 2024, Номер 29(21), С. 5080 - 5080
Опубликована: Окт. 27, 2024
The frequent and irrational use of antibiotics by humans has led to the escalating rise antimicrobial resistance (AMR) with a high rate morbidity-mortality worldwide, which poses challenge development effective treatments. A large number host defense peptides from different organisms have gained interest due their broad antibacterial spectrum, rapid action, low target resistance, implying that these natural sources might be new alternative drugs. As important effectors prey capture, against other animal attacks, competitor deterrence, scorpion venoms been developed as candidate for modern drug development. With progress bioanalytical throughput sequencing techniques, more scorpion-venom-derived peptides, including disulfide-bridged (DBPs) non-disulfide-bridged (NDBPs), recently identified having massive pharmacological activities in channelopathies, pathogen infections, cancer In this review, we summarize molecular diversity corresponding structural classification venom antibacterial, antifungal, and/or antiparasitic activity. We also aim improve understanding underlying mechanisms exert functions, finally highlight key aspects prospects therapeutic or pharmaceutical application.
Язык: Английский
Процитировано
2
Journal of Peptide Science, Год журнала: 2024, Номер unknown
Опубликована: Май 15, 2024
Prevalent worldwide, the Androctonus scorpion genus contributes a vital role in envenoming. While diverse scorpionisms are observed because of several different species, their secretions to protect themselves have been identified as potent source antimicrobial peptide (AMP)‐like compounds. Distinctly, venom these species contains around 24 AMPs, with definite molecules studied for therapeutic potential antimicrobial, antifungal, antiproliferative and antiangiogenic agents. Our review focuses on native synthetic AMPs so far genus, identifying research gaps therapeutics guiding further investigations. Certain demonstrated remarkable compatibility be prescribed anticancer drug reduce cancer cell proliferation serve antibiotic alternative. Besides, analyses were performed explore characteristics affinities peptides membranes. Overall, study derived from provides valuable insights into applications medicine development.
Язык: Английский
Процитировано
1
Advances in Microbiology, Год журнала: 2024, Номер 14(07), С. 366 - 388
Опубликована: Янв. 1, 2024
Viral diseases are minacious with the potential for causing pandemics and treatment is complicated because of their inherent ability to mutate become resistant drugs. Antiviral drug resistance a persistent problem that needs continuous attention by scientists, medical professionals, government agencies. To solve problem, an in-depth understanding intricate interplay between causes antiviral new drugs specifically natural products imperative in interest safety public health. This review delves into product as reservoir agents peculiar potentials addressing complexities associated multi-drug emerging viral strains. An evaluation mechanisms underlying activity, addressed, emphasis on production broad-spectrum from sources. There need continued product-based research, identification species novel compounds.
Язык: Английский
Процитировано
1
Опубликована: Авг. 30, 2024
Mosquitoes are responsible for the transmission of numerous pathogens, including Plasmodium parasites, arboviruses and filarial worms. They pose a significant risk to public health with over 200 million cases malaria per annum approximately four billion people at arthropod-borne viruses (arboviruses). Mosquito populations geographically expanding into temperate regions their distribution is predicted continue increasing. symbionts, fungi, bacteria viruses, have desirable traits mosquito disease control spreading horizontally vertically through potentially colonising multiple important vector species. Paratransgenesis, genetic modification symbionts effectors target pathogen rather than vector, promising strategy prevent spread mosquito-borne diseases. A variety can be expressed but venom toxins excellent effector candidates because they specific, potent, and, stable. However, only explored in paratransgenesis date Scorpine mutated phospholipase A2. To enhance scope, effectiveness, durability paratransgenesis, an expanded arsenal required. This review discusses other potential future studies based on prior vitro vivo antiparasitic antiviral highlights need further research investment this area. In terms diseases, strategies been developed Plasmodium. We postulate apply principle using toxin effectors.
Язык: Английский
Процитировано
1
Frontiers in Chemistry, Год журнала: 2024, Номер 12
Опубликована: Сен. 26, 2024
Venoms are complex mixtures produced by animals and consist of hundreds components including small molecules, peptides, enzymes selected for effectiveness efficacy over millions years evolution. With the development venomics, which combines genomics, transcriptomics, proteomics to study animal venoms their effects deeply, researchers have identified molecules that selectively effectively act against membrane targets, such as ion channels G protein-coupled receptors. Due remarkable physico-chemical properties, these represent a credible source new lead compounds. Today, not less than 11 approved venom-derived drugs on market. In this review, we aimed highlight advances in use venom peptides treatment diseases neurological disorders, cardiovascular diseases, or cancer. We report origin activity already provide comprehensive overview those still development.
Язык: Английский
Процитировано
1
Toxins, Год журнала: 2024, Номер 16(11), С. 497 - 497
Опубликована: Ноя. 18, 2024
Scorpion stings are a significant public health concern globally, particularly in tropical and subtropical regions. venoms contain diverse array of bioactive peptides, different scorpion species around the world typically exhibit varying venom profiles, resulting wide range envenomation symptoms. Despite their harmful effects, peptides hold immense potential for drug development due to unique characteristics. Therefore, establishment comprehensive database that catalogs scorpions along with known proteins is imperative furthering research efforts this area. We hereby present ScorpDb, novel offers convenient access data related species, found venoms, symptoms they can cause. To end, ScorpDb has been primarily advanced accommodate on Iranian fauna. From there, we propose future community include larger diversity components. holds promise become valuable resource professionals from variety fields, like toxinologists, arachnologists, pharmacologists. The available at https://www.scorpdb.com/.
Язык: Английский
Процитировано
1