In
recent
years,
a
growing
body
of
research
has
highlighted
the
significant
influence
microbiota
on
tumor
immunity
within
microenvironment
(TME).
While
much
attention
been
given
to
bacteria,
emerging
evidence
suggests
that
fungi
also
play
crucial
roles
in
development.
The
present
review
aimed
consolidate
latest
findings
mechanisms
governing
interactions
between
and
immune
system
or
TME.
By
elucidating
these
intricate
mechanisms,
novel
insights
into
modulation
therapeutic
strategies
may
be
uncovered.
Ultimately,
deeper
understanding
interplay
TME
holds
promise
for
development
innovative
management
targeted
drugs
enhance
therapy
efficacy.
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 122 - 164
Опубликована: Март 11, 2024
Cancer,
a
critical
health
concern,
necessitates
safer,
more
effective
treatments.
This
chapter
explores
the
anticancer
potential
of
traditional
Thai
plants,
which,
despite
being
underresearched,
show
significant
promise.
It
focuses
on
bioactive
compounds
and
their
efficacy
against
various
cancer
types.
The
categorizes
these
plants
based
active
components
reviews
both
laboratory
animal
studies
to
understand
underlying
mechanisms
involved
in
inhibiting
cell
growth,
inducing
death,
preventing
tumor
blood
vessel
formation.
Clinical
trials
supporting
findings
are
also
highlighted.
Given
improve
or
innovate
treatments,
present
encouraging
prospects.
However,
further
research
is
essential
confirm
safety
approaches.
These
suggest
that
could
lead
development
innovative
drugs,
signaling
advancements
therapy.
Ultrasonics Sonochemistry,
Год журнала:
2024,
Номер
103, С. 106803 - 106803
Опубликована: Фев. 1, 2024
Zizania
latifolia
is
a
highly
nutritious
vegetable
being
praised
as
"Ginseng
in
Water".
Polysaccharides
are
the
main
bioactive
ingredients
Z.
latifolia,
but
there
have
been
no
reports
on
yield-
and
activity-guided
ultrasonic-assisted
extraction
(UAE),
sulfation
anti-non-small
cell
lung
cancer
(NSCLC)
activity.
In
this
study,
polysaccharides
(ZLP)
were
extracted
using
UAE
under
an
optimized
power,
followed
by
to
give
three
derivatives
(SZLP-1
∼
3).
After
characterization,
antioxidant
anti-NSCLC
activities
evaluated.
The
optimal
ultrasonic
power
for
ZLP
was
screened
out
be
300
W,
which
yield
16.9
±
2.10
%,
scavenging
rate
against
2,
2-diphenyl-1-picrylhydrazyl
(DPPH)
radical
63.3
5.71
significantly
higher
than
those
of
other
powers
hot-water
extraction.
A
series
characterizations
fully
confirmed
sulfated
modification
ZLP.
Sulfation
improved
antioxidation
positively
proportional
degree
substitution
(DS),
SZLP-2
with
DS
15.1
2.50
elicited
strong
hydroxyl
DPPH
radicals-scavenging
capacities.
Meanwhile,
also
exerted
promising
potency
via
inhibiting
A549
proliferation,
median
inhibition
concentration
(IC
BMC Complementary Medicine and Therapies,
Год журнала:
2025,
Номер
25(1)
Опубликована: Фев. 28, 2025
Abstract
Background
Lung
cancer
is
one
of
the
most
prevalent
malignancies
globally
and
leading
cause
cancer-related
mortality.
Although
cisplatin
a
widely
utilized
chemotherapeutic
agent,
its
clinical
efficacy
often
hampered
by
significant
toxicity
undesirable
side
effects.
Rosa
canina,
medicinal
plant,
has
demonstrated
range
beneficial
biological
activities,
including
anti-inflammatory,
anticancer,
immunomodulatory,
antioxidant,
genoprotective
Methods
This
study
aimed
to
investigate
potential
canina
enhance
anticancer
in
dimethyl
benz(a)anthracene-induced
lung
model
using
female
rats.
The
animals
were
administered
cisplatin,
or
combination
both
treatments.
expression
levels
critical
signaling
molecules
evaluated,
phosphoinositide-3-kinase
(PI3K),
Akt,
mammalian
target
rapamycin
(mTOR),
cleaved
poly
(ADP-ribose)
polymerase
(PARP-1),
myeloid
differentiation
factor
88
(MyD88),
tumor
necrosis
receptor-associated
(TRAF),
addition
various
autophagic
markers.
Furthermore,
we
assessed
toll-like
receptor
2
(TLR2),
nuclear
kappa
B
(NF-κB),
apoptotic
markers
tissue,
complemented
histopathological
examinations.
Results
combined
treatment
extract
significantly
inhibited
cell
proliferation
downregulating
PARP-1
TLR2/MyD88/TRAF6/NF-κB
pathway,
as
well
PI3K/Akt/mTOR
pathway.
Moreover,
this
therapy
promoted
autophagy
apoptosis,
evidenced
elevated
Conclusion
Overall,
findings
suggest
that
enhances
effects
inhibiting
while
simultaneously
inducing
apoptosis.
Thus,
can
be
used
adjuvant
chemotherapy
overcome
limitations
which
may
considered
new
approach
during
strategy.
Graphical
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Май 9, 2025
Rubus
chingii
Hu
(
R
.
)
is
a
valuable
edible
and
medicinal
plant.
It
contains
variety
of
surprising
active
compositions.
For
example,
polysaccharides,
phenols,
terpenes,
organic
acids,
benzenes,
flavonoids.
Among
them,
as
macromolecular
compounds,
are
receiving
increasing
attention
from
researchers.
Polysaccharides
obtained
have
anti-tumor,
anti-colitis,
immunomodulatory,
anti-obesity,
antioxidant
cytoprotective
effects.
In
this
paper,
the
extraction,
purification,
structural
characteristics
health
benefits
polysaccharides
were
reviewed,
which
laid
knowledge
foundation
provided
direction
for
future
research.
addition,
structure-activity
relationship
was
analyzed.
Its
actual
potential
applications
in
fields
food,
pharmaceuticals,
cosmetics
also
been
discussed.
This
provides
inspiration
research
development
its
products
functional
foods.
summary,
by
reviewing
on
recent
years,
it
will
help
researchers
deepen
their
understanding
them
facilitate
further
polysaccharides.
