Is exposure to Bisphenol A associated with Attention-Deficit Hyperactivity Disorder (ADHD) and associated executive or behavioral problems in children? A comprehensive systematic review. DOI Creative Commons
Hugo Zoppé,

Jean Xavier,

Antoine Dupuis

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 167, P. 105938 - 105938

Published: Nov. 16, 2024

Numerous studies have investigated environmental risk factors in ADHD, and Bisphenol A (BPA), an endocrine disruptor, is suspected by several reviews. However, the quality of has never been carefully assessed, leading us to rigorously examine associations between BPA exposure ADHD associated symptoms children. Using PRISMA criteria, we conducted a systematic review on MEDLINE/PubMed, Web Science, EBSCOhost, PsycINFO, PsycARTICLES Cochrane databases. We used ROBINS-E tool assess quality, GRADE Approach. This study was registered with PROSPERO, CRD42023377150. Out 10446 screened articles, 46 were included. Unlike pre-existing reviews, most failed find clear links or symptoms, high bias very low level certainty. Our reveals insufficient evidence regarding impact despite some behavioral results that cannot be generalized. Future will require improved consideration confounding more precise sampling methods. did not receive specific funding.

Language: Английский

Integrating network pharmacology with molecular docking and dynamics to uncover therapeutic targets and signaling mechanisms of vitamin D3 in Parkinson’s disease DOI
Cheng Wang, Yiling Wang,

Qiu-Han Xu

et al.

Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Language: Английский

Citations

1
Recent Insights on the Role of Nuclear Receptors in Alzheimer’s Disease: Mechanisms and Therapeutic Application DOI Open Access

Xiaoxiao Shan,

Dawei Li,

Huihui Yin

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1207 - 1207

Published: Jan. 30, 2025

Nuclear receptors (NRs) are ligand-activated transcription factors that regulate a broad array of biological processes, including inflammation, lipid metabolism, cell proliferation, and apoptosis. Among the diverse family NRs, peroxisome proliferator-activated (PPARs), estrogen receptor (ER), liver X (LXR), farnesoid (FXR), retinoid (RXR), aryl hydrocarbon (AhR) have garnered significant attention for their roles in neurodegenerative diseases, particularly Alzheimer’s disease (AD). NRs influence pathophysiology AD through mechanisms such as modulation amyloid-beta (Aβ) deposition, regulation inflammatory pathways, improvement neuronal function. However, dual role progression, where some may exacerbate while others offer therapeutic potential, presents critical challenge application treatment. This review explores functional diversity highlighting involvement AD-related processes discussing prospects NR-targeting strategies. Furthermore, key challenges, necessity precise identification beneficial detailed structural analysis molecular dynamics simulations, further investigation NR AD, tau pathology autophagy, also discussed. Collectively, continued research is essential to clarify ultimately facilitating potential use diagnosis, prevention, treatment AD.

Language: Английский

Citations

0
Endogenous 17β-estradiol regulates sexually dimorphic anxiety responses in zebrafish via the HPI axis and 5-HT/DA pathways DOI Creative Commons
Hong Tao, Yingying Zhang,

Yanjun Shen

et al.

Frontiers in Marine Science, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 7, 2025

Anxiety is a multifaceted emotional response exhibited by animals when confronted with potential threats. Among most vertebrates, including mammals and fish, there pronounced sexual dimorphism in anxiety responses, females typically demonstrating higher levels than males. Concurrently, endogenous estrogen levels, specifically 17β-estradiol (E2), are significantly compared to This suggests positive regulatory role of E2 on anxiety, contributing sexually dimorphic fish. To elucidate the mediating male zebrafish ( Danio rerio ) were administered (E2-M), while treated letrozole (LET, an aromatase inhibitor that reduces synthesis, LET-F) for 60 days, plasma brain detected was evaluated novel tank diving test. Females (C-F) showed along elevated cortisol brain, reduced serotonin (5-HT) dopamine (DA) males (C-M). Treatment LET decreased female zebrafish, which corresponded lower increased 5-HT DA content. Additionally, expression genes associated E2, cortisol, 5- HT, pathways relevantly altered. Conversely, treatment (E2-M) content, corresponding changes gene expression. These findings strongly suggest positively regulates responses possibly modulating synthesis action 5-HT/DA brain.

Language: Английский

Citations

0
The role of estrogen in Alzheimer’s disease pathogenesis and therapeutic potential in women DOI

Xinyi Wang,

Shu Feng,

Qianting Deng

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Language: Английский

Citations

3
Genome-wide association study of copy number variations in Parkinson's disease DOI Creative Commons
Zied Landoulsi, Ashwin Ashok Kumar Sreelatha, Claudia Schulte

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 22, 2024

Our study investigates the impact of copy number variations (CNVs) on Parkinson's disease (PD) pathogenesis using genome-wide data, aiming to uncover novel genetic mechanisms and improve understanding role CNVs in sporadic PD.

Language: Английский

Citations

0
Is exposure to Bisphenol A associated with Attention-Deficit Hyperactivity Disorder (ADHD) and associated executive or behavioral problems in children? A comprehensive systematic review. DOI Creative Commons
Hugo Zoppé,

Jean Xavier,

Antoine Dupuis

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 167, P. 105938 - 105938

Published: Nov. 16, 2024

Numerous studies have investigated environmental risk factors in ADHD, and Bisphenol A (BPA), an endocrine disruptor, is suspected by several reviews. However, the quality of has never been carefully assessed, leading us to rigorously examine associations between BPA exposure ADHD associated symptoms children. Using PRISMA criteria, we conducted a systematic review on MEDLINE/PubMed, Web Science, EBSCOhost, PsycINFO, PsycARTICLES Cochrane databases. We used ROBINS-E tool assess quality, GRADE Approach. This study was registered with PROSPERO, CRD42023377150. Out 10446 screened articles, 46 were included. Unlike pre-existing reviews, most failed find clear links or symptoms, high bias very low level certainty. Our reveals insufficient evidence regarding impact despite some behavioral results that cannot be generalized. Future will require improved consideration confounding more precise sampling methods. did not receive specific funding.

Language: Английский

Citations

0