Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Апрель 8, 2022

Depression is a global health problem with growing prevalence rates and serious impacts on the daily life of patients. However, side effects currently used antidepressants greatly reduce compliance Quercetin flavonol present in fruits, vegetables, Traditional Chinese medicine (TCM) that has been proved to have various pharmacological such as anti-depressant, anti-cancer, antibacterial, antioxidant, anti-inflammatory, neuroprotective. This review summarizes evidence for application quercetin treat depression. We clarified mechanisms regulating levels neurotransmitters, promoting regeneration hippocampal neurons, improving hypothalamic-pituitary-adrenal (HPA) axis dysfunction, reducing inflammatory states anti-oxidative stress. also summarized antidepressant some glycoside derivatives provide reference further research clinical application.

Язык: Английский

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The therapeutic effects of saikosaponins on depression through the modulation of neuroplasticity: From molecular mechanisms to potential clinical applications

Pharmacological Research, Год журнала: 2024, Номер 201, С. 107090 - 107090

Опубликована: Фев. 2, 2024

Depression is a major global health issue that urgently requires innovative and precise treatment options. In this context, saikosaponin has emerged as promising candidate, offering variety of therapeutic benefits may be effective in combating depression. This review delves into the multifaceted potential saikosaponins alleviating depressive symptoms. We summarized effects on structural functional neuroplasticity, elaborated regulatory mechanism modulating key factors affect such inflammation, hypothalamic-pituitary-adrenal (HPA) axis, oxidative stress, brain-gut axis. Moreover, paper highlights existing gaps current researches outlines directions for future studies. A detailed plan provided clinical application saikosaponins, advocating more targeted to speed up its transition from preclinical trials practice.

Язык: Английский

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Anti-colorectal cancer actions of Glycyrrhiza uralensis Fisch. and its underlying mechanism via HPLC integration and network pharmacological approaches

Phytomedicine, Год журнала: 2025, Номер 138, С. 156370 - 156370

Опубликована: Янв. 7, 2025

Язык: Английский

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The antidepressive mechanism of Longya Lilium combined with Fluoxetine in mice with depression-like behaviors

npj Systems Biology and Applications, Год журнала: 2024, Номер 10(1)

Опубликована: Янв. 13, 2024

Abstract Traditional Chinese medicine is one of the most commonly used complementary and alternative therapies for depression. Integrated Chinese-western have been extensively applied in numerous diseases due to their superior efficiency individual treatment. We meta-analysis, network pharmacology, bioinformatics studies identify putative role Longya Lilium combined with Fluoxetine Depression-like behaviors were mimicked mice after exposure chronic unpredictable mild stress (CUMS). The underlying potential mechanism this combination therapy was further explored based on vitro vivo experiments analyze expression COX-2, PGE2, IL-22, activation microglial cells, neuron viability apoptosis hippocampus. antidepressant effect noted compared a single COX-2 mainly expressed hippocampal CA1 areas. reduced thus alleviated depression-like behavior neuroinflammation mice. A decrease curtailed BV-2 cell activation, inflammation, by blunting PGE2/IL-22 axis. Therefore, inactivates COX-2/PGE2/IL-22 axis, consequently relieving neuroinflammatory response resultant

Язык: Английский

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Du-moxibustion ameliorates depression-like behavior and neuroinflammation in chronic unpredictable mild stress-induced mice

Journal of Affective Disorders, Год журнала: 2024, Номер 358, С. 211 - 221

Опубликована: Май 3, 2024

Neuroinflammation is involved in the advancement of depression. Du-moxibustion can treat Here, we explored whether could alleviate neuroglia-associated neuro-inflammatory process chronic unpredictable mild stress (CUMS) mice.

Язык: Английский

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Network pharmacology and experimental evidence: ERK/CREB/BDNF signaling pathway is involved in the antidepressive roles of Kaiyu Zhishen decoction

Journal of Ethnopharmacology, Год журнала: 2024, Номер 329, С. 118098 - 118098

Опубликована: Апрель 4, 2024

Язык: Английский

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Non-linear association between Mediterranean diet and depressive symptom in U.S. adults: A cross-sectional study

Frontiers in Psychiatry, Год журнала: 2022, Номер 13

Опубликована: Июль 15, 2022

The Mediterranean diet (MED), a dietary pattern rich in fruits and vegetables, whole grains, legumes, nuts, fish, olive oil, has anti-oxidative anti-inflammatory effects. Although some data suggest that MED adherence is associated with decreased manifestation of depressive symptoms, it remains necessary to further analyze this apparent non-linear association as well the influence different factors on relationship between depression. Here, we investigated associations alternate (aMED) score symptom via multivariate logistic regression, weighted generalized additive (GAM) two-step linear regression models, analyzing from 2005-2018 National Health Nutrition Examination Survey (NHANES). most important factor relevant aMED contributed prevalence was assessed using random forest. Furthermore, examined whether differs by age, race, sex, socioeconomic variables, lifestyle- health-related chronic medical conditions, subgroup analyses. A total 19,477 participants (20-80 years age) were included cross-sectional study. In crude adjusted (1-5) increased noted associate non-depressive status, defined Patient Questionnaire-9 (P < 0.05). Data analyses GAM two-piecewise revealed symptom, which had an inflection point 3. Random forest results vegetable contributes greatest symptom. Subgroup significantly negatively related populations 0.05) exception high annual income, diabetes, borderline blood glucose level Parkinson's disease (PD) > conclusion, observed Further studies are needed validate our results.

Язык: Английский

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Neferine alleviates chronic stress-induced depression by regulating monoamine neurotransmitter secretion and gut microbiota structure

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Сен. 2, 2022

Neferine (Nef) might possess anti-depressive properties; however, its therapeutic effects are yet to be elucidated. Therefore, in this study, we aimed explore the anti-depressant property of Nef using a mouse model chronic stress-induced depression. Fifteen depression-prone mice were randomly selected and divided into three groups, namely, model, Nef, fluoxetine (Flu) groups. We observed that tail suspension forced swimming tests, Flu treatments significantly decreased immobility time depressed mice, increased their sucrose preference indices. Moreover, both induced significant increases levels neurotransmitters, including dopamine (DA), serotonin (5-HT), norepinephrine (NE), also reduced pathological damage hippocampus mice. Incidentally, Illumina MiSeq sequencing analysis demonstrated relative abundance Lactobacillus intestinal microbiota was restored after Nef/Flu treatment. colonic positively correlated with DA, 5-HT, NE In conclusion, improved monoamine neurotransmitter secretion modulated flora structure, particularly . Hence, it showed considerable potential, prospective agent.

Язык: Английский

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Improving hemodialysis patient depression outcomes with acupuncture: A randomized controlled trial

Acta Psychologica, Год журнала: 2025, Номер 253, С. 104728 - 104728

Опубликована: Янв. 30, 2025

Язык: Английский

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Naoxintong Is Involved in the Coagulation Regulation of Warfarin Through the MAPK Pathway

Pharmacogenomics and Personalized Medicine, Год журнала: 2025, Номер Volume 18, С. 35 - 46

Опубликована: Янв. 1, 2025

To explore the effect of Naoxintong (NXT) on warfarin anticoagulation therapy and its potential mechanism. TCSMP, SwissTargetprediction, SuperPred, SEA, Batmanic-TCM were used to search for active ingredients targets NXT warfarin; DisGENT database was find disease coagulation disorders. Cytoscape software applied construct "drug-target"network; protein interaction network (PPI) study protein-protein interaction. GO KEGG functional analysis. The then tested in rats by analyzing factors blood before after drug administration. expression MAPK liver tissue determined Western blot. top five components affecting degree value MOL000098, MOL000422, MOL000006, MOL000358, MOL000449. TP53, AKT1, SRC, TNF, HSP90AA1, STAT3, JUN, IL6, EGFR, ESR1 core NXT, while MAPK9, MAP3K5, MAPK8, MAPK1 family important process. In vivo testing indicated that may be able participate regulation process through multiple pathways, which related MAPK. Our data suggests is involved pathway.

Язык: Английский

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