Amomum tsao-ko crevost et lemaire ameliorates depression-like behaviors and hippocampal inflammation by inhibiting microglia activation and HMGB1/TLR4/NF-κB pathway in diabetic mice with depression

Metabolic Brain Disease, Год журнала: 2025, Номер 40(4)

Опубликована: Март 28, 2025

Язык: Английский

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Arecoline Alleviates Depression via Gut–Brain Axis Modulation, Neurotransmitter Balance, Neuroplasticity Enhancement, and Inflammation Reduction in CUMS Mice

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

This study evaluated the antidepressant effects of arecoline, a bioactive alkaloid derived from areca nuts, using mouse model depression induced by chronic unpredictable mild stress. Arecoline treatment significantly alleviated depression-like behaviors, including anxiety, anhedonia, and despair, as evidenced behavioral tests. Mechanistically, arecoline restored serotonin norepinephrine levels in brain serum, reduced pro-inflammatory markers such IL-1β LPS both serum colon, enhanced hippocampal neuroplasticity through increased BDNF PSD-95 expression. Moreover, modulated gut microbiota composition, particularly enriching beneficial species like Bifidobacterium pseudolongum Ligilactobacillus murinus, regulated metabolites associated with tryptophan metabolism, neurotransmitter synthesis, oxidative These findings demonstrate that exerts its via multitargeted approach involving gut-brain axis, modulation, enhancement. highlights promising therapeutic candidate for depression, emphasizing potential to address central peripheral mechanisms.

Язык: Английский

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Formononetin ameliorates depression-like behaviors through rebalancing microglia M1/M2 polarization and inhibiting NLRP3 inflammasome: involvement of activating PPARα-mediated autophagy

Molecular Medicine, Год журнала: 2025, Номер 31(1)

Опубликована: Апрель 24, 2025

Abstract Background The dysregulation of neuroinflammation triggered by imbalance microglia M1/M2 polarization is a key pathogenic factor and closely associated with occurrence depression. Formononetin (FMN), natural non-steroidal isoflavonoid, has been confirmed to exhibit remarkable anti-inflammatory efficacy, but the impact FMN on depression underlying antidepressant mechanisms are still not fully understood. This study aimed investigate whether effect involved in modulating polarization, if so, what mechanisms. Methods Lipopolysaccharide (LPS)-induced depressive mice were used FMN. Microglia cell line BV2 stimulated LPS was employed pharmacological Effects neuronal damage detected H&E, Nissl Golgi staining. efficacy evaluated immunostaining western blots vivo vitro . In addition, molecular docking, luciferase reporter assay, cellular thermal shift assay (CETSA) drug affinity responsive target stability (DARTS) confirm direct Results Our results showed that significantly reverses depression-like behaviors, alleviates damage, rebalances inhibits NLRP3 inflammasome enhances microglial autophagy level prefrontal cortex LPS-induced mice. assays, unraveled inhibitor chloroquine (CQ) blocks effects inhibiting rebalancing polarization. Moreover, PPARα identified as can activate PPARα-mediated autophagy. Furtherly, combination agonist (WY14643) had no significant additive whereas antagonist (GW6471) abrogated these pharmacologic BV2. Importantly, GW6471 exhibited similar abolish Conclusion firstly demonstrated rebalance inhibit inflammasome, involvement activating ameliorate which provides novel view elucidate also offers potential therapeutic for

Язык: Английский

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Zhi-Zi-Chi decoction ameliorates depression-like behavior in chronic unpredictable mild stress-induced mice via the PI3K/AKT/mTOR signaling pathway

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119987 - 119987

Опубликована: Май 1, 2025

Язык: Английский

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Innovative strategies for post-stroke depression: integrating traditional Chinese medicine with neurobiological insights, including the gut-brain axis

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Июнь 3, 2025

Post-stroke depression (PSD) is a debilitating condition affecting more than one-third of stroke survivors, leading to significant impairments in mood, cognitive function, and overall quality life. While conventional treatments like selective serotonin reuptake inhibitors (SSRIs) are commonly used, their efficacy often limited, they associated with adverse side effects. Emerging research underscores the critical roles neuroinflammation, neurotransmitter imbalances, disruptions gut-brain axis development progression PSD, suggesting that targeting these pathways could lead effective therapeutic outcomes. Traditional Chinese Medicine (TCM) presents promising multi-faceted approach, addressing complex biological mechanisms by regulating systems, modulating immune responses, restoring gut microbiota balance. Key herbs such as Salvia miltiorrhiza Bunge (Lamiaceae; Dan Shen) Bupleurum chinense DC. (Apiaceae; Chai Hu) have shown potential levels, reducing providing neuroprotection. Additionally, TCM formulations Chaihu Shugan Powder (CSP) Jieyu Capsules (SG) further enhance effects promoting homeostasis metabolic This review delves into underlying particular focus on dysregulation, dysfunction. It also explores integrating advanced multi-omics technologies—such metabolomics, metagenomics, transcriptomics—to develop personalized treatment strategies for PSD. By combining holistic principles modern Western medicine cutting-edge omics technologies, this integrative approach offers comprehensive framework managing significantly improve recovery outcomes life survivors.

Язык: Английский

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Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPARγ and STAT1 signaling

International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113538 - 113538

Опубликована: Ноя. 3, 2024

Язык: Английский

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MiR-182-5p: A Novel Biomarker in the Treatment of Depression in CSDS-Induced Mice

The International Journal of Neuropsychopharmacology, Год журнала: 2023, Номер 27(1)

Опубликована: Дек. 1, 2023

Abstract Background Depression is a neuropsychiatric disease with high disability rate and mainly caused by the chronic stress or genetic factors. There increasing evidence that microRNAs (miRNAs) play critical role in pathogenesis of depression. However, underlying molecular mechanism for pathophysiology depression miRNA remains entirely unclear so far. Methods We first established social defeat (CSDS) mice model depression, depression-like behaviors were evaluated series behavioral tests. Next, we detected several abundantly expressive miRNAs suggested previous reports to be involved found miR-182-5p was selected as candidate analysis hippocampus. Then western blotting immunofluorescence used together examine whether adeno-associated virus (AAV)-siR-182-5p treatment alleviated stress–induced decrease hippocampal Akt/GSK3β/cAMP-response element binding protein (CREB) signaling pathway increase neurogenesis impairment neuroinflammation. Furthermore, CREB inhibitor adopted if blockade Akt/GSK3β/CREB abolished antidepressant actions AAV-siR-182-5p mice. Results Knockdown impaired CSDS-induced Intriguingly, usage agomiR-182-5p produced significant increases immobility times aggravated neuronal damage More importantly, it 666-15 blocked reversal effects on depressive-like testing within hippocampus Conclusions These findings indicated miR-182-5p/Akt/GSK3β/CREB participated might give more opportunities new drug developments based target clinic.

Язык: Английский

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Camellia nitidissima Chi extract promotes adult hippocampal neurogenesis and attenuates chronic corticosterone-induced depressive behaviours through regulating Akt/GSK3β/CREB signaling pathway

Journal of Functional Foods, Год журнала: 2022, Номер 95, С. 105199 - 105199

Опубликована: Июль 26, 2022

Hormonal imbalance causes depressive behaviours in chronic mental disorders. The use of natural products to relieve symptoms is getting attention due its minimal side effects and multiple health benefits. present study aims test the hypothesis that Camellia nitidissima Chi leave extract (CNC) could have antidepressant whose underlying mechanisms be related promote hippocampal neurogenesis. Firstly, we conducted quality control identified 17 active compounds CNC extract. Then, performed a series behaviour tests evaluate corticosterone (CORT)-induced mouse model. significantly ameliorated CORT-induced behaviours, were similar sertraline. Interestingly, decreased levels CORT ACTH plasma increased 5-HT hippocampus. promoted adult neurogenesis CORT-treated mice vivo. neurogenic also confirmed primary cultured neurons hESCs with challenge vitro. Furthermore, enhanced phosphorylation Akt, GSK3β CREB hippocampus vivo as well PC12 cells Co-treatment wortmannin abolished CNC. Taken together, an effective functional food stimulate for anti-depressant treatment. regulating hypothalamic–pituitaryadrenal axis activating Akt/GSK3β/CREB signaling pathway.

Язык: Английский

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Reveal the potent antidepressant effects of Zhi-Zi-Hou-Pu Decoction based on integrated network pharmacology and DDI analysis by deep learning

Heliyon, Год журнала: 2024, Номер 10(22), С. e38726 - e38726

Опубликована: Окт. 3, 2024

Язык: Английский

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Natural products that alleviate depression: The putative role of autophagy

Pharmacology & Therapeutics, Год журнала: 2024, Номер unknown, С. 108731 - 108731

Опубликована: Окт. 1, 2024

Язык: Английский

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