Shugan Jiangni Hewei Granule regulates synaptic plasticity in central sensitization via NGF/TrkA Signaling Pathways in psychological stress rats with nonerosive reflux disease DOI Creative Commons

Guang Bai,

Yuebo Jia, Tianzuo Wang

et al.

Research Square (Research Square), Journal Year: 2022, Volume and Issue: unknown

Published: April 12, 2022

Abstract Objective. We sought to investigate the mechanism of visceral hypersensitivity improvement Shugan Jiangni Hewei Granules (SJHG) treatment non-erosive reflux disease (NERD) and provide an experimental basis for its clinical application. Methods. Fifty healthy male Sprague-Dawley (SD) rats were divided into 5 groups, with 10 in each group, including normal group (healthy rats), model (model without any treatment), SJHG Omeprazole k252a treated 100μmol/kg NGF/TrkA pathway inhibitor).The esophageal mucosa synaptic vesicles spinal cord observed by EMT, NGF, TrkA, PSD95, GAP43 proteins expression detected western blot, GluA1 protein was immunohistochemistry among PSD95 immunofluorescence. Results. In intercellular spaces epithelia widened, increased compared group. NGF amd TrkA significantly (P<0.01), After or k252a, decreased rats. (P<0.01). GAP43, proeins higher than that group.(P<0.01). Compared (P<0.05), but no significant difference CREB mRNA expression. The content low. According integrated optical density (IOD), both signifcantly Conclusions. can ameliorate decrease central mental stress disease, which is partially due regulation signaling pathways. Psychological factor also important cause hypersensitivity. These findings provided a new target Traditional Chinese medicine NERD improve viscera.

Language: Английский

Naoxintong Is Involved in the Coagulation Regulation of Warfarin Through the MAPK Pathway DOI Creative Commons
Luo Xiao,

Ling Chen,

J Xu

et al.

Pharmacogenomics and Personalized Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 35 - 46

Published: Jan. 1, 2025

To explore the effect of Naoxintong (NXT) on warfarin anticoagulation therapy and its potential mechanism. TCSMP, SwissTargetprediction, SuperPred, SEA, Batmanic-TCM were used to search for active ingredients targets NXT warfarin; DisGENT database was find disease coagulation disorders. Cytoscape software applied construct "drug-target"network; protein interaction network (PPI) study protein-protein interaction. GO KEGG functional analysis. The then tested in rats by analyzing factors blood before after drug administration. expression MAPK liver tissue determined Western blot. top five components affecting degree value MOL000098, MOL000422, MOL000006, MOL000358, MOL000449. TP53, AKT1, SRC, TNF, HSP90AA1, STAT3, JUN, IL6, EGFR, ESR1 core NXT, while MAPK9, MAP3K5, MAPK8, MAPK1 family important process. In vivo testing indicated that may be able participate regulation process through multiple pathways, which related MAPK. Our data suggests is involved pathway.

Language: Английский

Citations

0
Non-linear association between Mediterranean diet and depressive symptom in U.S. adults: A cross-sectional study DOI Creative Commons
Yaohua Fan,

Lijun Zhao,

Zhiyuan Deng

et al.

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 13

Published: July 15, 2022

The Mediterranean diet (MED), a dietary pattern rich in fruits and vegetables, whole grains, legumes, nuts, fish, olive oil, has anti-oxidative anti-inflammatory effects. Although some data suggest that MED adherence is associated with decreased manifestation of depressive symptoms, it remains necessary to further analyze this apparent non-linear association as well the influence different factors on relationship between depression. Here, we investigated associations alternate (aMED) score symptom via multivariate logistic regression, weighted generalized additive (GAM) two-step linear regression models, analyzing from 2005-2018 National Health Nutrition Examination Survey (NHANES). most important factor relevant aMED contributed prevalence was assessed using random forest. Furthermore, examined whether differs by age, race, sex, socioeconomic variables, lifestyle- health-related chronic medical conditions, subgroup analyses. A total 19,477 participants (20-80 years age) were included cross-sectional study. In crude adjusted (1-5) increased noted associate non-depressive status, defined Patient Questionnaire-9 (P < 0.05). Data analyses GAM two-piecewise revealed symptom, which had an inflection point 3. Random forest results vegetable contributes greatest symptom. Subgroup significantly negatively related populations 0.05) exception high annual income, diabetes, borderline blood glucose level Parkinson's disease (PD) > conclusion, observed Further studies are needed validate our results.

Language: Английский

Citations

16
Neferine alleviates chronic stress-induced depression by regulating monoamine neurotransmitter secretion and gut microbiota structure DOI Creative Commons
Zaiquan Dong,

Qinglian Xie,

Feiyu Xu

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 2, 2022

Neferine (Nef) might possess anti-depressive properties; however, its therapeutic effects are yet to be elucidated. Therefore, in this study, we aimed explore the anti-depressant property of Nef using a mouse model chronic stress-induced depression. Fifteen depression-prone mice were randomly selected and divided into three groups, namely, model, Nef, fluoxetine (Flu) groups. We observed that tail suspension forced swimming tests, Flu treatments significantly decreased immobility time depressed mice, increased their sucrose preference indices. Moreover, both induced significant increases levels neurotransmitters, including dopamine (DA), serotonin (5-HT), norepinephrine (NE), also reduced pathological damage hippocampus mice. Incidentally, Illumina MiSeq sequencing analysis demonstrated relative abundance Lactobacillus intestinal microbiota was restored after Nef/Flu treatment. colonic positively correlated with DA, 5-HT, NE In conclusion, improved monoamine neurotransmitter secretion modulated flora structure, particularly . Hence, it showed considerable potential, prospective agent.

Language: Английский

Citations

15
Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPARγ and STAT1 signaling DOI

Paul Su,

Liming Liu,

Yuhang Gong

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113538 - 113538

Published: Nov. 3, 2024

Language: Английский

Citations

2
MiR-182-5p: A Novel Biomarker in the Treatment of Depression in CSDS-Induced Mice DOI Creative Commons

Yabin Zheng,

Xiaoming Sheng, Xiang Jin

et al.

The International Journal of Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 27(1)

Published: Dec. 1, 2023

Abstract Background Depression is a neuropsychiatric disease with high disability rate and mainly caused by the chronic stress or genetic factors. There increasing evidence that microRNAs (miRNAs) play critical role in pathogenesis of depression. However, underlying molecular mechanism for pathophysiology depression miRNA remains entirely unclear so far. Methods We first established social defeat (CSDS) mice model depression, depression-like behaviors were evaluated series behavioral tests. Next, we detected several abundantly expressive miRNAs suggested previous reports to be involved found miR-182-5p was selected as candidate analysis hippocampus. Then western blotting immunofluorescence used together examine whether adeno-associated virus (AAV)-siR-182-5p treatment alleviated stress–induced decrease hippocampal Akt/GSK3β/cAMP-response element binding protein (CREB) signaling pathway increase neurogenesis impairment neuroinflammation. Furthermore, CREB inhibitor adopted if blockade Akt/GSK3β/CREB abolished antidepressant actions AAV-siR-182-5p mice. Results Knockdown impaired CSDS-induced Intriguingly, usage agomiR-182-5p produced significant increases immobility times aggravated neuronal damage More importantly, it 666-15 blocked reversal effects on depressive-like testing within hippocampus Conclusions These findings indicated miR-182-5p/Akt/GSK3β/CREB participated might give more opportunities new drug developments based target clinic.

Language: Английский

Citations

5
Natural products that alleviate depression: The putative role of autophagy DOI

Yunfeng Zhou,

Fajun Nan, Qianwen Zhang

et al.

Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: unknown, P. 108731 - 108731

Published: Oct. 1, 2024

Language: Английский

Citations

1
Camellia nitidissima Chi extract promotes adult hippocampal neurogenesis and attenuates chronic corticosterone-induced depressive behaviours through regulating Akt/GSK3β/CREB signaling pathway DOI Creative Commons
Bun Tsoi, Chong Gao,

Shenyu Yan

et al.

Journal of Functional Foods, Journal Year: 2022, Volume and Issue: 95, P. 105199 - 105199

Published: July 26, 2022

Hormonal imbalance causes depressive behaviours in chronic mental disorders. The use of natural products to relieve symptoms is getting attention due its minimal side effects and multiple health benefits. present study aims test the hypothesis that Camellia nitidissima Chi leave extract (CNC) could have antidepressant whose underlying mechanisms be related promote hippocampal neurogenesis. Firstly, we conducted quality control identified 17 active compounds CNC extract. Then, performed a series behaviour tests evaluate corticosterone (CORT)-induced mouse model. significantly ameliorated CORT-induced behaviours, were similar sertraline. Interestingly, decreased levels CORT ACTH plasma increased 5-HT hippocampus. promoted adult neurogenesis CORT-treated mice vivo. neurogenic also confirmed primary cultured neurons hESCs with challenge vitro. Furthermore, enhanced phosphorylation Akt, GSK3β CREB hippocampus vivo as well PC12 cells Co-treatment wortmannin abolished CNC. Taken together, an effective functional food stimulate for anti-depressant treatment. regulating hypothalamic–pituitaryadrenal axis activating Akt/GSK3β/CREB signaling pathway.

Language: Английский

Citations

7
Reveal the potent antidepressant effects of Zhi-Zi-Hou-Pu Decoction based on integrated network pharmacology and DDI analysis by deep learning DOI Creative Commons
Zhiwen Zhang, Xiaojing Li,

Zihui Huang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(22), P. e38726 - e38726

Published: Oct. 3, 2024

Language: Английский

Citations

1
NMR-based metabolomics approach to study the effect and related molecular mechanisms of Saffron essential oil against depression DOI
Ying Zhou, Ziwei Chen, Feng Su

et al.

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 247, P. 116244 - 116244

Published: May 20, 2024

Language: Английский

Citations

0
Progress of research on the treatment of depression by traditional Chinese medicine prescriptions DOI Creative Commons
Yiwei Chen, Ruyu Wang, Xue Li

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e34970 - e34970

Published: July 26, 2024

Depression is a common psychiatric disorder that belongs to the category of "Depression Syndrome" in traditional Chinese medicine (TCM), and its etiology pathogenesis are complex unclear. It characterized by high prevalence, disability rate, recurrence which seriously affect human health, treatment has become research hotspot worldwide. At present, antidepressants commonly used clinic mainly Western (WM), but there problems such as frequent side effects poor efficacy. Studies have found use TCM prescriptions depression can achieve same effect WM; when combined with WM, efficacy be enhanced while adverse WM reduced. Pharmacological studies related (TCMPs) focused on neurobiochemical system, gut microbes, energy metabolism mitochondria. No one yet reviewed pharmacological mechanism TCMPs for depression. So, this paper reviews from perspective TCMPs, introduces progress classical their antidepressant mechanism. This article aims promote application provide new therapeutic idea clinical

Language: Английский

Citations

0