20(S)‐protopanaxatriol inhibited D‐galactose‐induced brain aging in mice via promoting mitochondrial autophagy flow

Phytotherapy Research, Год журнала: 2023, Номер 37(7), С. 2827 - 2840

Опубликована: Апрель 10, 2023

Previous reports have confirmed that saponins (ginsenosides) derived from Panax ginseng. C. A. Meyer exerted obvious memory-enhancing and antiaging effects, the simpler structure of ginsenosides, better biological activity. In this work, we aimed to explore therapeutic effect underlying molecular mechanism 20(S)-protopanaxatriol (PPT), aglycone panaxatriol-type by establishing D-galactose (D-gal)-induced subacute brain aging model in mice. The results showed PPT treatment (10 20 mg/kg) for 4 weeks could significantly restore D-gal (800 mg/kg 8 weeks)-induced impaired memory function, choline dysfunction, redox system imbalance Meanwhile, also reduced histopathological changes caused exposure. Moreover, increase TFEB/LAMP2 protein expression promote mitochondrial autophagic flow. Importantly, docking had good binding ability with LAMP2 TFEB, suggesting might play an important role alleviate D-gal-caused aging.

Язык: Английский

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American Ginseng for the Treatment of Alzheimer’s Disease: A Review

Molecules, Год журнала: 2023, Номер 28(15), С. 5716 - 5716

Опубликована: Июль 28, 2023

Alzheimer’s disease (AD) is a prevalent degenerative condition that increasingly affecting populations globally. American ginseng (AG) has anti-AD bioactivity, and ginsenosides, as the main active components of AG, have shown strong effects in both vitro vivo studies. It been reported ginsenosides can inhibit amyloid β-protein (Aβ) production deposition, tau phosphorylation, apoptosis cytotoxicity, well possess anti-oxidant anti-inflammatory properties, thus suppressing progression AD. In this review, we aim to provide comprehensive overview pathogenesis AD, potential found underlying molecular mechanisms associated with these effects. Additionally, will discuss use AG treatment how may exert more potent be direction for further research.

Язык: Английский

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Review on Ginseng and its Potential Active Substance G-Rg2 Against Age-Related Diseases: Traditional Efficacy and Mechanism

Journal of Ethnopharmacology, Год журнала: 2024, Номер unknown, С. 118781 - 118781

Опубликована: Сен. 1, 2024

Язык: Английский

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Ginsenosides can target brain-derived neurotrophic factor to improve Parkinson's disease

Food & Function, Год журнала: 2023, Номер 14(12), С. 5537 - 5550

Опубликована: Янв. 1, 2023

Parkinson's disease (PD) is the second most common neurodegenerative (ND).

Язык: Английский

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Deoxynivalenol exposure disturbs the cytoplasmic maturation in porcine oocytes

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 285, С. 117137 - 117137

Опубликована: Сен. 30, 2024

Язык: Английский

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