Deoxynivalenol exposure disturbs the cytoplasmic maturation in porcine oocytes DOI Creative Commons

Linlin Hu,

Yaxi Liu, Xiaoting Yu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117137 - 117137

Published: Sept. 30, 2024

Language: Английский

20(S)‐protopanaxatriol inhibited D‐galactose‐induced brain aging in mice via promoting mitochondrial autophagy flow DOI

Jun‐jie Zhang,

Rui‐yi Hu,

Ke‐cheng Chen

et al.

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(7), P. 2827 - 2840

Published: April 10, 2023

Previous reports have confirmed that saponins (ginsenosides) derived from Panax ginseng. C. A. Meyer exerted obvious memory-enhancing and antiaging effects, the simpler structure of ginsenosides, better biological activity. In this work, we aimed to explore therapeutic effect underlying molecular mechanism 20(S)-protopanaxatriol (PPT), aglycone panaxatriol-type by establishing D-galactose (D-gal)-induced subacute brain aging model in mice. The results showed PPT treatment (10 20 mg/kg) for 4 weeks could significantly restore D-gal (800 mg/kg 8 weeks)-induced impaired memory function, choline dysfunction, redox system imbalance Meanwhile, also reduced histopathological changes caused exposure. Moreover, increase TFEB/LAMP2 protein expression promote mitochondrial autophagic flow. Importantly, docking had good binding ability with LAMP2 TFEB, suggesting might play an important role alleviate D-gal-caused aging.

Language: Английский

Citations

6
American Ginseng for the Treatment of Alzheimer’s Disease: A Review DOI Creative Commons

Mengyao Shan,

Yunfan Bai, Xiaoxue Fang

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(15), P. 5716 - 5716

Published: July 28, 2023

Alzheimer’s disease (AD) is a prevalent degenerative condition that increasingly affecting populations globally. American ginseng (AG) has anti-AD bioactivity, and ginsenosides, as the main active components of AG, have shown strong effects in both vitro vivo studies. It been reported ginsenosides can inhibit amyloid β-protein (Aβ) production deposition, tau phosphorylation, apoptosis cytotoxicity, well possess anti-oxidant anti-inflammatory properties, thus suppressing progression AD. In this review, we aim to provide comprehensive overview pathogenesis AD, potential found underlying molecular mechanisms associated with these effects. Additionally, will discuss use AG treatment how may exert more potent be direction for further research.

Language: Английский

Citations

6
Review on Ginseng and its Potential Active Substance G-Rg2 Against Age-Related Diseases: Traditional Efficacy and Mechanism DOI
Yu-Zhuo Zhang,

De-Yang Huo,

Zhi Liu

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118781 - 118781

Published: Sept. 1, 2024

Language: Английский

Citations

2
Ginsenosides can target brain-derived neurotrophic factor to improve Parkinson's disease DOI

Yingying Ding,

Benson O. A. Botchway, Yong Zhang

et al.

Food & Function, Journal Year: 2023, Volume and Issue: 14(12), P. 5537 - 5550

Published: Jan. 1, 2023

Parkinson's disease (PD) is the second most common neurodegenerative (ND).

Language: Английский

Citations

5
Deoxynivalenol exposure disturbs the cytoplasmic maturation in porcine oocytes DOI Creative Commons

Linlin Hu,

Yaxi Liu, Xiaoting Yu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117137 - 117137

Published: Sept. 30, 2024

Language: Английский

Citations

1