Non-Coding RNA,
Год журнала:
2024,
Номер
10(4), С. 44 - 44
Опубликована: Авг. 7, 2024
Liver
fibrosis
is
a
significant
contributor
to
liver-related
disease
mortality
on
global
scale.
Despite
this,
there
remains
dearth
of
effective
therapeutic
interventions
capable
reversing
this
condition.
Consequently,
it
imperative
that
we
gain
comprehensive
understanding
the
underlying
mechanisms
driving
liver
fibrosis.
In
regard,
activation
hepatic
stellate
cells
(HSCs)
recognized
as
pivotal
factor
in
development
and
progression
The
role
noncoding
RNAs
(ncRNAs)
epigenetic
regulation
HSCs
transdifferentiation
into
myofibroblasts
has
been
established,
providing
new
insights
gene
expression
changes
during
activation.
NcRNAs
play
crucial
mediating
epigenetics
HSCs,
serving
novel
regulators
pathogenesis
As
research
expands,
connection
between
ncRNAs
involved
becomes
more
evident.
These
have
attracted
considerable
attention
from
researchers
field.
Furthermore,
contributed
valuable
drug
discovery
identification
targets
for
individuals
suffering
cirrhosis.
such,
review
offers
thorough
discussion
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 2073 - 2088
Опубликована: Апрель 1, 2024
Abstract:
Pyroptosis
is
a
novel
pro-inflammatory
mode
of
programmed
cell
death
that
differs
from
ferroptosis,
necrosis,
and
apoptosis
in
terms
its
onset
regulatory
mechanisms.
dependent
on
cysteine
aspartate
protein
hydrolase
(caspase)-mediated
activation
GSDMD,
NLRP3,
the
release
cytokines,
interleukin-1
(IL-1β),
interleukin-18
(IL-18),
ultimately
leading
to
death.
Non-coding
RNA
(ncRNA)
type
does
not
encode
proteins
gene
transcription
but
plays
an
important
role
other
post-transcriptional
links.
NcRNA
mediates
pyroptosis
by
regulating
various
related
factors,
which
we
termed
signaling
pathway.
Previous
researches
have
manifested
closely
development
liver
diseases,
essential
for
injury,
alcoholic
fatty
disease
(ALD),
non-alcoholic
(NAFLD),
fibrosis,
cancer.
In
this
review,
attempt
address
ncRNA-mediated
pathway
above
diseases
their
pathogenesis
recent
years,
briefly
outline
TCM
(Traditional
Chinese
Medicine)
intervene
modulating
pyroptosis,
will
provide
strategy
find
new
therapeutic
targets
prevention
treatment
future.
Keywords:
non-coding
RNA,
inflammasomes,
gasdermin,
traditional
medicine
Clinical and Experimental Pharmacology and Physiology,
Год журнала:
2023,
Номер
51(1), С. 17 - 29
Опубликована: Сен. 25, 2023
Abstract
Liver
fibrosis
is
a
chronic
liver
lesion
caused
by
excessive
deposition
of
the
extracellular
matrix
after
damage,
resulting
in
fibrous
scarring
tissue.
The
progression
partially
influenced
gut
microbiota.
Chitosan
can
play
therapeutic
role
regulating
microbiota
based
on
‘gut–liver
axis’
theory.
Salvianolic
acid
B
inhibit
development
inhibiting
activation
hepatic
stellate
cells
and
reducing
production
matrix.
In
this
study,
effect
chitosan
combination
with
salvianolic
was
investigated
mouse
model.
results
showed
that
better
than
drug
alone,
improving
AST/ALT
levels
expression
α‐SAM,
COL
I,
IL‐6
other
related
genes.
It
improved
structure
increased
abundance
beneficial
bacteria
such
as
Lactobacillus.
above
could
provide
new
ideas
for
clinical
treatment
fibrosis.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 25, 2024
Distant
metastasis
is
a
major
cause
of
treatment
failure
in
cancer
patients
and
key
challenge
to
improving
care
today.
We
hypothesized
that
enhancing
anti-cancer
immune
response
inhibiting
circulating
tumor
cells
(CTCs)
adhesion
transendothelial
migration
through
synergistic
multi-target
approaches
may
effectively
prevent
metastasis.
“Fuyuan
Decoction”
(FYD)
traditional
Chinese
medicine
compound
widely
used
postoperative
patients,
but
its
underlying
mechanism
remains
unclear.
In
this
work,
we
systematically
elucidated
the
molecular
by
which
FYD
prevents
multi-compound
synergies
vitro
vivo
.
significantly
prevented
at
non-cytotoxic
concentrations
suppressing
CTCs
endothelial
their
subsequent
migration,
as
well
response.
Mechanistically,
interrupts
vascular
endothelium
TNF-α-induced
CAMs
expression
via
regulation
NF-κB
signaling
pathway
cells.
inhibits
invasion
EMT,
PI3K/AKT
FAK
pathways.
Moreover,
enhances
increasing
population
Tc
NK
peripheral
system.
addition,
chemical
composition
was
determined
UPLC-HRMS,
results
indicated
multiple
compounds
treatment.
This
study
provides
modern
medical
basis
for
application
prevention
metastasis,
suggesting
multi-drug
therapy
be
one
most
effective
ways
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 30, 2024
Fibrosis
is
a
public
health
issue
of
great
concern
characterized
by
the
excessive
deposition
extracellular
matrix,
leading
to
destruction
parenchymal
tissue
and
organ
dysfunction
that
places
heavy
burden
on
global
healthcare
system
due
its
high
incidence,
disability,
mortality.
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Сен. 18, 2024
Liver
fibrosis
is
a
complex
process
driven
by
various
factors
and
key
feature
of
chronic
liver
diseases.
Its
essence
tissue
remodeling
caused
excessive
accumulation
collagen
other
extracellular
matrix.
Activation
hepatic
stellate
cells
(HSCs),
which
are
responsible
for
production,
plays
crucial
role
in
promoting
the
progression
fibrosis.
Abnormal
expression
signaling
pathways,
such
as
TGF-β/Smads
pathway,
contributes
to
HSCs
activation.
Recent
studies
have
shed
light
on
these
providing
valuable
insights
into
development
Here,
we
will
review
six
pathways
that
been
studied
more
recent
years.
The American Journal of Chinese Medicine,
Год журнала:
2024,
Номер
unknown, С. 1 - 36
Опубликована: Сен. 30, 2024
Liver
fibrosis
is
a
common
complication
of
chronic
liver
disease,
significantly
affecting
patients’
quality
life
and
potentially
leading
to
cirrhosis
hepatocellular
carcinoma.
Despite
advancements
in
modern
medicine,
the
treatment
remains
limited
challenging.
Thus,
identifying
new
therapeutic
strategies
great
clinical
importance.
Signaling
pathways
related
play
crucial
regulatory
role
immune
response
inflammation.
Aberrant
activation
specific
pathways,
such
as
NF-[Formula:
see
text]B
signaling
pathway,
results
overexpression
genes
associated
with
inflammation
fibrosis,
thereby
promoting
progression
fibrosis.
Chinese
medicine
offers
unique
potential
advantages
approach.
Recent
studies
have
increasingly
demonstrated
that
certain
medicines
can
effectively
treat
by
regulating
relevant
pathways.
The
active
ingredients
these
inhibit
hepatic
inflammatory
responses
fibrotic
processes
interfering
thus
reducing
severity
This
paper
aims
investigate
mechanisms
treating
its
modulation
Additionally,
it
discusses
prospects
application
treatments
provides
valuable
references
for
further
research
practice.
Non-Coding RNA,
Год журнала:
2024,
Номер
10(4), С. 44 - 44
Опубликована: Авг. 7, 2024
Liver
fibrosis
is
a
significant
contributor
to
liver-related
disease
mortality
on
global
scale.
Despite
this,
there
remains
dearth
of
effective
therapeutic
interventions
capable
reversing
this
condition.
Consequently,
it
imperative
that
we
gain
comprehensive
understanding
the
underlying
mechanisms
driving
liver
fibrosis.
In
regard,
activation
hepatic
stellate
cells
(HSCs)
recognized
as
pivotal
factor
in
development
and
progression
The
role
noncoding
RNAs
(ncRNAs)
epigenetic
regulation
HSCs
transdifferentiation
into
myofibroblasts
has
been
established,
providing
new
insights
gene
expression
changes
during
activation.
NcRNAs
play
crucial
mediating
epigenetics
HSCs,
serving
novel
regulators
pathogenesis
As
research
expands,
connection
between
ncRNAs
involved
becomes
more
evident.
These
have
attracted
considerable
attention
from
researchers
field.
Furthermore,
contributed
valuable
drug
discovery
identification
targets
for
individuals
suffering
cirrhosis.
such,
review
offers
thorough
discussion
